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KU - SCIENCE BIO - BRIC

2-year postdoc position in cancer genomics, Weischenfeldt research group, BRIC University of Copenhagen

Fuldtid

Tidsbegrænset

Ole Maaløes Vej 5, 2200 København N, Danmark

SE PÅ KORT
ID: 2611138
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Indrykket for 36 dage siden


We are looking for a highly motivated, creative, and talented PhD-level computational biologist to join our team. The postdoc position is in computational biology and cancer genomics, with a focus on chromatin architecture and genomic variants in cancer, commencing August 15th, 2024 or as soon as possible hereafter.



Our group and research

The Weischenfeldt lab is working on delineating the mutational mechanisms and clonal evolution of cancer, with a particular focus on genomic structural rearrangements. We use computational and experimental approaches including WGS, single-cell, and long-read sequencing together with chromatin conformation techniques to understand how cancers mutate and evolve, which we are applying to cancer patient material in close collaboration with clinical colleagues at the hospital.



Project description

The project involves integrative analysis of patient-derived genomic, epigenetic and clinical data to i) deconvolve different layers of chromatin organisation changes ii) investigate chromatin phenotypic consequences of mutations.

The successful candidates will be joining a larger team of cross-disciplinary cancer researchers, with the aims to identify mutational processes regulating the genomic organisation in cancer.



Starting date: August 15th or after agreement.

Duration: 2 (two) years with possibility for extension.

Principal supervisor is group leader, Prof Joachim Weischenfeldt, BRIC and Rigshospitalet, [email protected], Phone: +453545 6040



Your job
You will be working with data from patient-derived tumour material in collaboration with other team members. Your job will include development of novel and executing existing computational methods including machine learning methods to integrate genomics, transcriptomics and epigenomics data set to uncover genomic-epigenomic interactions and cancer evolution trajectories. The tasks will include quality assessment, processing and filtering of different data modalities, and co-supervision of junior researchers in the group. You will have the opportunity to develop your own research ideas and approaches. The position involves interdisciplinary research through exchange of ideas and results with clinicians and researchers.

Profile
We are looking for highly motivated and enthusiastic scientists with the following competencies and experience:

Essential experience and skills:

  • You have a PhD in computational biology, bioinformatics or related areas
  • You are highly experienced in working with NGS data and have experience with Hi-C data
  • You have an active interest in genetics and clonal evolution
  • Proficient communication skills and ability to work in teams
  • Excellent English skills written and spoken
Desirable experience and skills:

  • Experience with machine learning and statistics
  • Experience with tumour evolution reconstruction
  • Knowledge on mutational mechanisms in cancer
  • Publications as co-author or first author in a related area
  • Fellowships, grants and prizes
Place of employment

The place of employment is at BRIC, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Our research facilities include modern laboratories and access to HPC.
Please read more about our research at https://www.bric.ku.dk/Research/weischenfeldt-group/



Terms of employment

The position is a fixed-term position limited to a period of 2 (two) years with possibility for extension.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 35,000 DKK/ approx. 4,700 EUR (October 2021-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the Job Structure for Academic Staff at Universities 2020.



Questions
For further information please contact Joachim Weischenfeldt, [email protected]

Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).



Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore your application must include the following documents/attachments – all in PDF format:

1. Motivated letter of application (max. one page).

2. CV incl. education, work/research experience, language skills and other skills relevant for the position.

3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.

4. List of publications.

Letters of recommendation

Furthermore, the applicant should provide at least one letter of recommendation. To be taken into consideration, the letter must be signed by the supporting person with institutional letter head and in PDF-format. Please make sure that an easy match between the recommendation letter and the individual applicant is possible.

Application deadline: 31 May 2024, 23.59pm CET



We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.



The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant self.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.



University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates to apply regardless of personal background.



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