Do you want to be part of our pioneering journey to advance the way we use mathematical modelling to inform and guide drug discovery and development? Are you an experienced scientist with strong mathematical modelling skills and strong expertise within physiologically based pharmacokinetics (PBPK)? If so, apply today and join the Development PKPD department in a permanent position within the Research and Early Development organization at Novo Nordisk!
The position
In this role, you will utilize your proficiency within cutting-edge PBPK modelling and simulation across therapeutic areas. This requires efficient collaboration and communication with subject matter experts. You will be part of a growing team that collectively drives the implementation of mathematical modelling and engages with scientists from preclinical to late clinical development. The focus is to support and integrate in vitro and in vivo ADME, pharmacokinetics (PK), pharmacodynamic (PD), and biology understanding into mathematical modelling approaches.
Some of your main responsibilities will include:
Qualifications
You hold a Ph.D. within Life Science, Health, Medical, Physics, Math or Engineering sciences, or other disciplines related to Drug Metabolism and Pharmacokinetics (DMPK) and ideally have 10+ years of relevant experience (post PhD), of which at least 5 years are within the pharmaceutical/biotech industry in pharmacometrics or mathematical modelling and simulation. You have a proven track record within disciplines related to DMPK and an excellent understanding of theory and principles of advanced mathematical modelling and simulation and your ability to translate these tools into actionable insights is exceptional.
To succeed in the role, you have:
As a person, you are open-minded, keen to learn new skills and able to communicate with experts in other areas. You have exceptional communication and stakeholder management skills. Furthermore, you have demonstrated experience and a keen interest in mentoring and sharing knowledge with junior scientists and colleagues. In addition, you have excellent written and oral communication skills in English.
All candidates with relevant qualifications interested in the role are encouraged to apply. Your application might be considered for a different level of the same position.
About the department
In Development PKPD you will have dedicated and highly motivated colleagues supporting projects with pharmacokinetic and pharmacodynamic evaluation using a variety of modelling and simulation tools from early non-clinical development to submission. Our evaluation is essential to secure project progress.
In preclinical development we are responsible for predicting human PK and PK/PD, setting doses for preclinical studies and for first in human trials, and reporting toxicokinetics to GLP, as well as providing input to regulatory documents (e.g. IND, IMPD, NDA). During clinical development, we conduct the interim PK evaluation during early phase 1 trials and collaborate with clinical pharmacologists and clinical pharmacometrics to support later clinical pharmacology studies (e.g. Drug-Drug-Interaction, renal and hepatic impairment) as well as addressing PBPK and PK/PD related questions and issues as they may arise. The models inform and support drug discovery, development and regulatory interactions.
The department is anchored within Global Drug Discovery (GDD) in Research & Early Development (R&ED) and in our daily work, we have a close collaboration with all parts of the global Discovery and Development organization, global project teams as well as external collaborators.
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