A PhD-candidate to work on pharmacological photoprotection

We are seeking a highly motivated PhD candidate (3-year period) to work on pharmacological photoprotection. The project is funded by the newly established “Videnscenter for Hudkræft” a collaboration between the dematological departments at Privathospitalet Mølholm, Ålborg University Hospital and Bispebjerg Hospital. The employment is to begin on November 01, 2020 or soon thereafter. The project aims to explore pharmacological photoprotection in a murine skin cancer model and pave the way to clinical trials.

Sun exposure is the primary risk factor for keratinocyte cancer and despite massive prevention efforts, Danish incidences have risen to an estimated 38,500 per year. Pharmacological photoprotection is the concept of using pharmacological compounds before or after exposure to environmental carcinogens e.g. ultraviolet radiation. There is increasing evidence that compounds (e.g. nicotinamide and NSAIDS and less known plant- and marine- derived compounds), may be useful in keratinocyte cancer prophylaxis. The aim is to discover compounds that delay or even reduce photocarcinogenesis. Pharmacological compounds will be tested in well-established UVR-induced murine models. Promising drug candidates will subsequently be tested clinically.

It is a project headed by Professor Peter Bjerring, Department of Dermatology, Ålborg University, Associate Professor Flemming Andersen, Privathospitalet Mølholm, Vejle, Professor Merete Hædersdal and Senior Researcher Catharina Lerche, Department of Dermatology, Bispebjerg Hospital, Copenhagen.

Qualifications
Your main role in the project will be to search the literature for potential drug candidates, conduct murine skin cancer studies and potentially also clinical trials. You should have a master’s degree in pharmacy, chemistry, biochemistry, or equivalent academic qualifications. Prior experience with animal models, searching literature and skin research is an advantage. The successful candidate must be highly motivated and have the ability to efficiently structure his or her own work while at the same time being willing to contribute to the project team.

We offer
You will work on a highly interesting and challenging national project. Your primary work place will be at Department of Dermatology, Bispebjerg Hospital, which is the main dermatology center in Denmark with more than 85,000 consultations per year. The department hosts an integrated research facility and provides access to a large patient pool. Our research group features a cross-field collaboration between medical doctors, pharmacists, biotechnicians, and experts in pathology and skin cancer. Working language is English and proficiency in Danish is not required. Some travelling can be expected.

Salary and appointment terms
Salary, pension and terms of employment are in accordance with the agreement between the Danish Regions (Danske Regioner) and the relevant professional organization. The salary depends on background education and seniority. Note that candidates coming from abroad may be eligible for tax reductions. The position is open for candidates of all nationalities. The period of employment is three years.

Further information
You are welcome to directly contact Senior Researcher Catharina Lerche (catharina.margrethe.lerche@regionh.dk) for further information. You are welcome to send informal inquiries to this e-mail address. However, the full application must be handed in online as described below.

Application
Please apply before September 29th 2020. Incoming applications will be continuously evaluated. Applications must be submitted on-line through the RegionH job portal following the link "Apply", and should include:

  • A letter of motivation
  • Curriculum vitae
  • BSc/MSc diploma, preferentially including grade transcripts into the ECTS grading scale
All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.


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