A PhD Scholarship at Center for Chromosome Stability (CCS), Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (SUND), University of Copenhagen

A fully funded 3-year PhD position is available from March 1st 2018 or as soon as possible thereafter at the CCS, Department of Cellular and Molecular Medicine, University of Copenhagen. Associate Professor Luis Toledo will be the principal supervisor for the PhD student, and Prof. Ian D. Hickson will be the primary co-supervisor of this project.  
Project title 
Molecular mechanisms regulating the function and stability of replication forks 
Project description 
The stability of replication forks is essential for cells to fully duplicate their genome and be able to divide and proliferate. Replication stress can lead forks to fail or collapse, a process that can cause the accumulation of genomic instability and, in extreme cases, the death of the cell. To this day we still have just a superficial view of the molecular pathways and processes occurring at replication forks, and how cells deal with replication stress. In this project we will use a combination of modern quantitative techniques to identify and characterize the mechanisms that ensure the function of replication forks in human cells.  
Job description  
The key tasks as a PhD fellow at the Faculty are to:   

  • Carry out and complete an independent research project under supervision
  • Write scientific articles and the PhD thesis on the grounds of your research project
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
  • Obtain experience with teaching and/or other types of dissemination related to your PhD project
  • Participate in the undergraduate teaching of students in pharmaceutical sciences
  • Participate in national and international congresses and scientific meetings
  • Obtain experience from an external research institution, preferably abroad   
Research environment  
This project will be carried out in Asso. Prof. Toledo’s group in the Center for Chromosome Stability (http://ccs.ku.dk) that was recently established by a grant from The Danish National Research Foundation. It provides a top international level research environment to train young researchers in the fields of Cellular biology, Genetics and Biochemistry. The CCS currently employs 8 principal investigators, 3 technicians, 19 post docs/assistant professors, and 16 PhD students as well as a number of master students.  
Applicants should hold an MSc degree in biology, molecular biomedicine, biochemistry or a closely related field. Candidates who do not yet have their degree, but who are expecting to finish with 1–2 months, should specify the date when they expect to hand in their thesis. We are seeking a highly motivated and ambitious individual with good interpersonal and communication skills. Previous experience with techniques in the fields of human cellular and molecular biology, genetics and biochemistry (e.g. cell culture, PCR, western blotting, cloning, etc) will be considered advantageous. Specific experience in the use of fluorescence microscopes and in the DNA replication or DNA damage fields will be looked-for. Fluency in spoken and written English is a requirement. The scholarship is open to both Danish and international applicants.   
Applicants are requested to submit their application with the following documents: 
  • Curriculum vitae  
  • Certificates of Bachelor degree and MSc degree or the equivalent documents.  
  • A cover letter describing your research interests and reasons for applying to this position
  • A list of the publications (or manuscripts) that have been submitted or accepted for publication
  • Transcripts of university examinations (from both Bachelor and Master degrees) (in English) 
  • Contact details of two referees  
Applicants are encouraged to provide evidence of English and other skills.  
The deadline for applications is 27 February 2018. After the expiry of the deadline for application, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. The final selection of successful candidates will be made by the Head of Department, based on the recommendations of the assessment committee. Successful candidates will then be requested to formally apply for enrolment as a PhD student at the PhD school of the Faculty of Science, University of Copenhagen. For more information see: http://www.science.ku.dk/english/research/phd  ;
Terms of salary and employment  
Terms of appointment and payment are in accordance with the agreement between the Danish Ministry of Finance and the Danish Federation of Professional Associations (AC). The starting salary for candidates with an MSc degree will be a minimum of DKK 306,667 (April 2015 level) plus pension contribution, with the possibility of salary negotiation. The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of personal background.  
Further information can be obtained via email to CCS center administrator Ms Elin Ølgaard Erichsen (e-mail: ee@sund.ku.dk).  

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