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Declaration of interest regarding PhD project in experimental neuroscience

The Department of Neurobiology Research at SDU is looking for applicants for a PhD scholarship within the field of experimental neuroscience.
We are looking for a person with a relevant degree in Biomedicine, Molecular Biology, Human Biology, or Medicine (MSc or MD).

Research environment
In our laboratory we are studying cerebrovascular diseases of and trauma to the central nervous system, such as stroke and spinal cord injury (SCI) to try to understand the cellular and molecular mechanisms that contribute to secondary neuronal cell death.
We have primarily one main research objective, which is to study the neuro-inflammatory response that occurs following stroke and SCI with the aim to contribute to the development of novel therapies for stroke and SCI patients.

Project description
Neuroinflammation is a key feature of virtually all acute and chronic neurological diseases. Even though it is initiated as a protective response to CNS injury, when uncontrolled neuroinflammation leads to aberrant cellular activation with sustained production of damaging factors, including increased levels of tumor necrosis factor (TNF).
TNF is important for normal brain homeostasis, however, when elevated induces brain damage. Understanding the crosstalk between the cell populations involved in neuroinflammatory processes, specifically microglia and macrophages, and how the mediators produced by these cells regulate or trigger CNS inflammation will allow us to devise better and more selective therapies for CNS disorders.
With this proposal, we aim to target and understand soluble versus transmembrane TNF signaling mechanisms in neurons and microglia/macrophages, their triggers as well as their role in regulating and fighting neuroinflammation in acute and chronic CNS diseases.

Qualifications
The candidate must hold a relevant degree in Biomedicine, Molecular Biology, Human Biology, or Medicine and must be certified to work with laboratory animals.
Experience with basic research is a prerequisite and the candidate is expected to fulfil the criteria for enrolment as a Ph.D. student at the University of Southern Denmark. For more information, please visit: (https://www.sdu.dk/en/forskning/phd/phd_skoler/phdskolensundhedsvidenskab/phd_students/getting_started/qualification_requirements).

Experience with animal models for ischemic stroke and multiple sclerosis and behavioural tests is an advantage.
The candidate is expected to have experience with molecular techniques, such as qPCR, ELISA, and Western blotting.
Experience with immunohistochemistry, immunofluorescence, in vitro cell cultures, and bioinformatics is an advantage. 
The candidate is expected to spend 1 year at the University of Miami, FL, USA, and therefore must meet the criteria for obtaining a non-immigrant work visa to the USA.

For further information about the project, please contact:
Professor Kate Lykke Lambertsen
Department of Neurobiology Research
Institute of Molecular Medicine
University of Southern Denmark (SDU)
Tlf. +45 6550 3806   E-mail: klambertsen@health.sdu.dk

Applications must include:

• At letter stating the interest, motivation and qualifications for the project (max. 2 pages)
• Detailed CV, including personal contact information
• Certified copy of diploma (Master’s degree in a relevant field)

Applications must be submitted electronically using the link "Apply online". 
Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. 

Incomplete applications and applications received after the deadline will neither be considered nor evaluated. This also applies to reference letters.

Closing date August 1, 2020

Successful candidates will be asked to send an application to the PhD Secretariat, Faculty of Health Sciences, to be enrolled as PhD students.

The PhD programme will be carried out in accordance with Faculty regulations and the Danish Ministerial Order on the PhD Programme at the Universities (PhD order)

The terms of employment as a salaried PhD Research Fellow are stated in the Agreement between the Ministry of Finance and the Danish Confederation of Professional Associations (AC).

The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.


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