DTU Studieprojekt - Engineering of non-model bacteria for therapeutic production

Engineering of non-model bacteria for therapeutic production

Udbyder
Vejleder
Sted
København og omegn
Project

• Microbiome therapeutics represent a new class of drug delivery system, in which therapeutics are produced in situ in the body by live microbes. Currently the vast majority of microbiome therapeutics are being developed in well described microbial chassis, such as E. coli, as this facilities engineering, however these chassis are not necessarily the best adapted to production in the human gut, nor do they provide the most intrinsic benefits. In recent years many commensal gut bacteria have been linked to specific health benefits and they represent a wealth of untapped potential, with regards to future microbiome therapeutic chassis.

To fill this gap we have recently developed a work flow for the engineering of commensal gut bacteria, which we have implemented successfully. We are now looking to test this work flow for the production of therapeutic molecules in more species of previously unengineered commensal gut bacteria.

Skills
This project will equip you with skills in anaerobic culturing, working with non-model bacteria, cloning, experimental design, data management and using an electronic lab notebook.

Additional info

• You will be working in the Bacterial Synthetic Biology section at DTU Biosustain, led by Morten Sommer, in the microbiome therapeutics subgroup led by Ruben Vazquez Uribe. The project will be supervised by PhD student Carmen Sands. For more information on the group and what we do see: http://www.savingtheworldwithscience.com/
• If you are interested in this project please send your CV and latest transcript of your grades to Carmen (carsan@biosustain.dtu.dk)

Emneord

• Bioteknologi og biokemi
• Fysik
• Informationsteknologi
• Kemi
• Matematik
• Medicin og medicoteknik
• Transport og logistik
• Bakterier og mikroorganismer
• Biologiske systemer
• Celler
• Enzymer og proteiner
• Gener og genomer
• Syntetisk biologi
• Vira
• Billedanalyse
• Dataanalyse
• Teknisk kemi
• Matematisk modellering
• Fysiologisk modellering
• Høreapparater
• Hospitalsindretning
• Kunstige organer
• Medicinske apparater og systemer
• Nanomedicin
• Radioaktive lægemidler og isotoper
• Sundhed og sygdomme

• Biotechnology
• microbiome
• SyntheticBiology

Navn
Carmen Sands

Stilling
Ph.d.-studerende

Mail
carsan@biosustain.dtu.dk

Vejleder-info
Kandidatuddannelsen i Bioteknologi
Vejleder
Carmen Sands

ECTS-point
30 - 60

Type
Kandidatspeciale

Kandidatuddannelsen i Bioinformatik og Systembiologi
Vejleder
Carmen Sands

ECTS-point
30 - 60

Type
Kandidatspeciale

Kandidatuddannelsen i Medicin og Teknologi
Vejleder
Carmen Sands

ECTS-point
30 - 60

Type
Kandidatspeciale

Kandidatuddannelsen i Kemisk og Biokemisk Teknologi
Vejleder
Carmen Sands

ECTS-point
30 - 60

Type
Kandidatspeciale

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