Open Rank Scientist-ECM & fibrosis biologist in metabolic disease

Bemærk at denne jobannonce er udløbet!
Annoncen er udløbet, og stillingen kan ikke længere søges. Opslaget vises udelukkende som reference

Open rank Scientist in Discovery Screening Department, Discovery Biology China (DBC) unit, Novo Nordisk Research Centre China

Novo Nordisk is a focused healthcare company and a world leader in diabetes care. Novo Nordisk Research Centre China (NNRCC) is an integrated part of Novo Nordisk R&D organization. We’re committed to identifying and delivering innovative therapies for the treatment of serious chronic diseases including diabetes, obesity, NASH, CDK and CVD. This position affords the exciting opportunity to join our team to fulfill this mission.

We are seeking an exceptional, self-motivated scientist who is passionate about this mission and has expertise and experience in identification and validation of novel therapeutic targets for the treatment of metabolic disease related to tissue fibrosis , including liver, cardiovascular, kidney, etc.

Using in vitro disease models coupled with forward and reverse screens, you will play a key role to investigate the functions of targets and validate their potential in therapeutic intervention to address unmet medical needs. Working cross-functionally within Novo Nordisk, you will oversee the progression of early proof of concepts for preclinical targets.

Opportunities

  • Independently develop, optimize, and validate ECM/fibrosis-relevant in vitro assays that are predictable of clinical outcome.
  • Lead collaborative efforts with internal and external partners focused on the validation of targets for the treatment of tissue fibrosis in metabolic diseases.
  • Oversee, maintain, and continuously improve the infrastructure and workflow of target identification and validation.
  • Contribute to the global R&D projects and pipeline.
  • Network and establish collaboration with external partners.
  • Develop innovative technologies to solve unmet medical needs.
  • Qualifications

  • PhD in biology, cell biology, molecular biology or related disciplines with education or working experience.
  • Superior knowledge of the current preventative and therapeutic developmental and clinical testing landscapes/pipelines about fibrosis disease treatment is required.
  • Deep understanding of the molecular/cellular basis of TGF ß biology, ECM remodelling, myofibroblast activation and inactivation, tissue fibrosis initiation, progression & regression, related to chronic metabolic disorders such as NASH, diabetes, obesity, CKD and CVD is required.
  • Experience in both developing monocellular and multicellular 2D and 3D cell cultures, with fibrosis relevant readouts for target validation is preferred.
  • Broad experience and skills in cell biology experiments (flow cytometry, high-content imaging, assay development) is a plus.
  • Solid proficiency in molecular biology and biochemistry techniques such as molecular cloning, PCR, RT-PCR, mammalian cell culture, immunoblot, plasmid transfection, ELISA, and immunocytochemistry/immunohistochemistry procedures is a plus.
  • Experience with gene perturbation tools, such as CRISPR-Cas9, Orfeome, and RNAi screens is a plus.
  • Excellent problem-solving skills and track record of driving changes.
  • Demonstrated ability to work independently or in a team-oriented environment.
  • Be able to manage multiple competing responsibilities with a high degree of self-motivation.
  • Demonstrated professional maturity.
  • Outstanding verbal and written communication skills in English.
  • Ability to network, expand influence, and achieve success in a globalized research setting.
  • Demonstrated record of practical, translational thinking and accomplishments.
  • Solid organization and time management skills.
  • Working at Novo Nordisk

    At Novo Nordisk you will work with specialists from around the world. Our ambitious teams work toward developing the next generation of care. We offer unique possibilities for personal and professional development, as well as a chance to work alongside the best in the field. 

    We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. 

    At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.

    Print job Send to e-mail

    Skriv i din ansøgning, at du fandt jobbet på ofir.dk


    Open Rank Scientist-ECM & fibrosis biologist in metabolic disease

    Open rank Scientist in Discovery Screening Department, Discovery Biology China (DBC) unit, Novo Nordisk Research Centre China

    Novo Nordisk is a focused healthcare company and a world leader in diabetes care. Novo Nordisk Research Centre China (NNRCC) is an integrated part of Novo Nordisk R&D organization. We’re committed to identifying and delivering innovative therapies for the treatment of serious chronic diseases including diabetes, obesity, NASH, CDK and CVD. This position affords the exciting opportunity to join our team to fulfill this mission.

    We are seeking an exceptional, self-motivated scientist who is passionate about this mission and has expertise and experience in identification and validation of novel therapeutic targets for the treatment of metabolic disease related to tissue fibrosis , including liver, cardiovascular, kidney, etc.

    Using in vitro disease models coupled with forward and reverse screens, you will play a key role to investigate the functions of targets and validate their potential in therapeutic intervention to address unmet medical needs. Working cross-functionally within Novo Nordisk, you will oversee the progression of early proof of concepts for preclinical targets.

    Opportunities

  • Independently develop, optimize, and validate ECM/fibrosis-relevant in vitro assays that are predictable of clinical outcome.
  • Lead collaborative efforts with internal and external partners focused on the validation of targets for the treatment of tissue fibrosis in metabolic diseases.
  • Oversee, maintain, and continuously improve the infrastructure and workflow of target identification and validation.
  • Contribute to the global R&D projects and pipeline.
  • Network and establish collaboration with external partners.
  • Develop innovative technologies to solve unmet medical needs.
  • Qualifications

  • PhD in biology, cell biology, molecular biology or related disciplines with education or working experience.
  • Superior knowledge of the current preventative and therapeutic developmental and clinical testing landscapes/pipelines about fibrosis disease treatment is required.
  • Deep understanding of the molecular/cellular basis of TGF ß biology, ECM remodelling, myofibroblast activation and inactivation, tissue fibrosis initiation, progression & regression, related to chronic metabolic disorders such as NASH, diabetes, obesity, CKD and CVD is required.
  • Experience in both developing monocellular and multicellular 2D and 3D cell cultures, with fibrosis relevant readouts for target validation is preferred.
  • Broad experience and skills in cell biology experiments (flow cytometry, high-content imaging, assay development) is a plus.
  • Solid proficiency in molecular biology and biochemistry techniques such as molecular cloning, PCR, RT-PCR, mammalian cell culture, immunoblot, plasmid transfection, ELISA, and immunocytochemistry/immunohistochemistry procedures is a plus.
  • Experience with gene perturbation tools, such as CRISPR-Cas9, Orfeome, and RNAi screens is a plus.
  • Excellent problem-solving skills and track record of driving changes.
  • Demonstrated ability to work independently or in a team-oriented environment.
  • Be able to manage multiple competing responsibilities with a high degree of self-motivation.
  • Demonstrated professional maturity.
  • Outstanding verbal and written communication skills in English.
  • Ability to network, expand influence, and achieve success in a globalized research setting.
  • Demonstrated record of practical, translational thinking and accomplishments.
  • Solid organization and time management skills.
  • Working at Novo Nordisk

    At Novo Nordisk you will work with specialists from around the world. Our ambitious teams work toward developing the next generation of care. We offer unique possibilities for personal and professional development, as well as a chance to work alongside the best in the field. 

    We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. 

    At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.

    Print job Send to e-mail

    Skriv i din ansøgning, at du fandt jobbet på ofir.dk


    +

    Mere af samme slags?

    Modtag jobannoncer der minder om dette job i din indbakke.




    Når du tilmelder dig accepterer du samtidig vores privatlivspolitik. Du kan altid trække dit samtykke tilbage.