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PhD fellow in Computational structural biology, Department of Biology



One or two PhD positions are available from September 1, 2019, or as soon as possible thereafter, in the Lindorff-Larsen group, Department of Biology, Faculty of Science, University of Copenhagen, Denmark. The PhD students will work on a project called BRAINSTRUC within the area of computational aspects of integrative structural biology. BRAINSTRUC is a collaboration between six research groups within structural biology spanning a range of techniques and biological topics, and the successful candidate(s) will be part of a strong and interdisciplinary group of scientists working on developing and applying methods to study the structure and dynamics of proteins.



About BRAINSTRUC and the research environment

The successful candidates will work on computational approaches in integrative structural biology and will be supervised by Professor Kresten Lindorff-Larsen. The project is part of a large interdisciplinary effort called BRAINSTRUC (www.brainstruc.ku.dk) funded by the Lundbeck Foundation. In addition to the Lindorff-Larsen group, the project also involves groups devoted to experimental biophysics and structural biology including X-ray crystallography, CryoEM, NMR, SAXS and SANS. The biological focus within BRAINSTRUC is on protein molecules and complexes in the human brain including membrane transporters, the immune system and protein aggregation. The PhD student will use molecular simulations and modelling to study these systems in collaboration with the experimental groups within BRAINSTRUC (for more details including the other partners see www.brainstruc.ku.dk).



We offer a highly dynamic and international research environment located at the Biocenter in central Copenhagen, Denmark (www.bio.ku.dk). The Lindorff-Larsen group combines computational and experimental methods to study the structure, function and dynamics of biomacromolecules. Research within the group covers a broad range of areas in protein science including understanding the relationship between protein dynamics and function, protein design, protein folding and stability, drug resistance, and determining the structures of proteins by integrating experiments and simulations.



The group is part of the Linderstrøm-Lang Centre for Protein Science at the Department of Biology. The research at the centre is highly interdisciplinary ranging from molecular cell biology to protein chemistry, advanced biophysics and computational biology. The centre also has access to state of the art experimental and computational facilities.



Project description

The PhD students will work on one or more of the subprojects within BRAINSTRUC, focusing on computational methods, both existing and newly developed, together with experimental data to determine the structure and dynamics of complex biomolecules and their assemblies. Experimental data include from SAXS, SANS, Cryo-EM, NMR, X-ray diffraction, and other sources of structural information. For an introduction to the research topic see e.g. our recent review (Bottaro et al, Science, 2018, http://dx.doi.org/10.1126/science.aat4010).



Research topics for the PhD projects include:



  • Using coarse-grained and all-atom simulations to study large molecular complexes
  • Using molecular simulations to interpret cryoEM experiments
  • Integrative methods to study intrinsically disordered proteins


Principal supervisor is Professor Kresten Lindorff-Larsen, Linderstrøm-Lang Centre for Protein Science and Structural Biology and NMR Laboratory Department of Biology, lindorff@bio.ku.dk.



Job description

The position is available for a 3-year period and your key tasks as a PhD student at SCIENCE are:



  • To manage and carry through your research project
  • Attend PhD courses
  • Write scientific articles and your PhD thesis
  • Teach and disseminate your research
  • To stay at an external research institution for a few months
  • Work for the department


Qualifications

We are seeking motivated and strong applicants with a MSc degree in biophysics, physics, chemistry or biochemistry or similar fields. The ideal candidate has with documented research experience within the area of biomolecular simulation. Experience with methods that integrate experimental data and computation will be a strong plus, as will simulations of large molecular assemblies. Experience with working with membrane proteins is also a plus.



Candidates must have good interpersonal and communication skills. Fluency in spoken and written English is a requirement.



Terms of employment

The position is covered by the Memorandum on Job Structure for Academic Staff.



Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.



The starting salary is currently at a minimum DKK 325.625 (approx. €43,400) including annual supplement (+ pension up to DKK 44,980). Negotiation for salary supplement is possible.



Application Procedure

The application, in English, must be submitted electronically by clicking APPLY NOW below.



Please include

  • A cover letter (max 1. page) explaining your background, key skills and how they are relevant to the research in BRAINSTRUC, and your motivation for applying
  • Curriculum vitae (max 2. pages) including educational background previous research experience
  • List of publications (including preprints and papers in review)
  • Diploma and transcripts of records (BSc and MSc)
  • Contact details for two former employers or supervisors (no reference letters should be attached)




The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.



The deadline for applications is 19th July 2019 23:59 GMT +2.



After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. Afterwards an assessment committee will be appointed to evaluate the selected applications. The applicants will be notified of the composition of the committee and the final selection of a successful candidate will be made by the Head of Department, based on the recommendations of the assessment committee and the interview committee.

The main criterion for selection will be the research potential of the applicant and the above mentioned skills. The successful candidate will then be requested to formally apply for enrolment as a PhD student at the PhD school of Science. You can read more about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/.



Questions

For specific information about the PhD scholarship, please contact the principal supervisor Professor Kresten Lindorff-Larsen, Linderstrøm-Lang Centre for Protein Science and Structural Biology and NMR Laboratory Department of Biology, lindorff@bio.ku.dk.



General information about PhD programmes at SCIENCE is available at http://www.science.ku.dk/phd.




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330048932Phoenix-c9f5e1a712019-06-25T00:00:00PhD fellow in Computational structural biology, Department of Biology

One or two PhD positions are available from September 1, 2019, or as soon as possible thereafter, in the Lindorff-Larsen group, Department of Biology, Faculty of Science, University of Copenhagen, Denmark. The PhD students will work on a project called BRAINSTRUC within the area of computational aspects of integrative structural biology. BRAINSTRUC is a collaboration between six research groups within structural biology spanning a range of techniques and biological topics, and the successful candidate(s) will be part of a strong and interdisciplinary group of scientists working on developing and applying methods to study the structure and dynamics of proteins.



About BRAINSTRUC and the research environment

The successful candidates will work on computational approaches in integrative structural biology and will be supervised by Professor Kresten Lindorff-Larsen. The project is part of a large interdisciplinary effort called BRAINSTRUC (www.brainstruc.ku.dk) funded by the Lundbeck Foundation. In addition to the Lindorff-Larsen group, the project also involves groups devoted to experimental biophysics and structural biology including X-ray crystallography, CryoEM, NMR, SAXS and SANS. The biological focus within BRAINSTRUC is on protein molecules and complexes in the human brain including membrane transporters, the immune system and protein aggregation. The PhD student will use molecular simulations and modelling to study these systems in collaboration with the experimental groups within BRAINSTRUC (for more details including the other partners see www.brainstruc.ku.dk).



We offer a highly dynamic and international research environment located at the Biocenter in central Copenhagen, Denmark (www.bio.ku.dk). The Lindorff-Larsen group combines computational and experimental methods to study the structure, function and dynamics of biomacromolecules. Research within the group covers a broad range of areas in protein science including understanding the relationship between protein dynamics and function, protein design, protein folding and stability, drug resistance, and determining the structures of proteins by integrating experiments and simulations.



The group is part of the Linderstrøm-Lang Centre for Protein Science at the Department of Biology. The research at the centre is highly interdisciplinary ranging from molecular cell biology to protein chemistry, advanced biophysics and computational biology. The centre also has access to state of the art experimental and computational facilities.



Project description

The PhD students will work on one or more of the subprojects within BRAINSTRUC, focusing on computational methods, both existing and newly developed, together with experimental data to determine the structure and dynamics of complex biomolecules and their assemblies. Experimental data include from SAXS, SANS, Cryo-EM, NMR, X-ray diffraction, and other sources of structural information. For an introduction to the research topic see e.g. our recent review (Bottaro et al, Science, 2018, http://dx.doi.org/10.1126/science.aat4010).



Research topics for the PhD projects include:



  • Using coarse-grained and all-atom simulations to study large molecular complexes
  • Using molecular simulations to interpret cryoEM experiments
  • Integrative methods to study intrinsically disordered proteins


Principal supervisor is Professor Kresten Lindorff-Larsen, Linderstrøm-Lang Centre for Protein Science and Structural Biology and NMR Laboratory Department of Biology, lindorff@bio.ku.dk.



Job description

The position is available for a 3-year period and your key tasks as a PhD student at SCIENCE are:



  • To manage and carry through your research project
  • Attend PhD courses
  • Write scientific articles and your PhD thesis
  • Teach and disseminate your research
  • To stay at an external research institution for a few months
  • Work for the department


Qualifications

We are seeking motivated and strong applicants with a MSc degree in biophysics, physics, chemistry or biochemistry or similar fields. The ideal candidate has with documented research experience within the area of biomolecular simulation. Experience with methods that integrate experimental data and computation will be a strong plus, as will simulations of large molecular assemblies. Experience with working with membrane proteins is also a plus.



Candidates must have good interpersonal and communication skills. Fluency in spoken and written English is a requirement.



Terms of employment

The position is covered by the Memorandum on Job Structure for Academic Staff.



Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.



The starting salary is currently at a minimum DKK 325.625 (approx. €43,400) including annual supplement (+ pension up to DKK 44,980). Negotiation for salary supplement is possible.



Application Procedure

The application, in English, must be submitted electronically by clicking APPLY NOW below.



Please include

  • A cover letter (max 1. page) explaining your background, key skills and how they are relevant to the research in BRAINSTRUC, and your motivation for applying
  • Curriculum vitae (max 2. pages) including educational background previous research experience
  • List of publications (including preprints and papers in review)
  • Diploma and transcripts of records (BSc and MSc)
  • Contact details for two former employers or supervisors (no reference letters should be attached)




The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.



The deadline for applications is 19th July 2019 23:59 GMT +2.



After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. Afterwards an assessment committee will be appointed to evaluate the selected applications. The applicants will be notified of the composition of the committee and the final selection of a successful candidate will be made by the Head of Department, based on the recommendations of the assessment committee and the interview committee.

The main criterion for selection will be the research potential of the applicant and the above mentioned skills. The successful candidate will then be requested to formally apply for enrolment as a PhD student at the PhD school of Science. You can read more about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/.



Questions

For specific information about the PhD scholarship, please contact the principal supervisor Professor Kresten Lindorff-Larsen, Linderstrøm-Lang Centre for Protein Science and Structural Biology and NMR Laboratory Department of Biology, lindorff@bio.ku.dk.



General information about PhD programmes at SCIENCE is available at http://www.science.ku.dk/phd.



2019-07-20T00:51:55.107 One or two PhD positions are available from September 1, 2019, or as soon as possible thereafter, in the Lindorff-Larsen group, Department of Biology, Faculty of Science, University of Copenhagen, Denmark. The PhD students will work on a project called BRAINSTRUC within the area of computational aspects of integrative structural biology. BRAINSTRUC is a collaboration between six research groups within structural biology spanning a range of techniques and biological topics, and the successful candidate(s) will be part of a strong and interdisciplinary group of scientists working on developing and applying methods to study the structure and dynamics of proteins. About BRAINSTRUC and the research environment The successful candidates will work on computational approaches in integrative structural biology and will be supervised by Professor Kresten Lindorff-Larsen. The project is part of a large interdisciplinary effort called BRAINSTRUC (www.brainstruc.ku.dk) funded by the Lundbeck Foundation. In addition to the Lindorff-Larsen group, the project also involves groups devoted to experimental biophysics and structural biology including X-ray crystallography, CryoEM, NMR, SAXS and SANS. The biological focus within BRAINSTRUC is on protein molecules and complexes in the human brain including membrane transporters, the immune system and protein aggregation. The PhD student will use molecular simulations and modelling to study these systems in collaboration with the experimental groups within BRAINSTRUC (for more details including the other partners see www.brainstruc.ku.dk). We offer a highly dynamic and international research environment located at the Biocenter in central Copenhagen, Denmark (www.bio.ku.dk). The Lindorff-Larsen group combines computational and experimental methods to study the structure, function and dynamics of biomacromolecules. Research within the group covers a broad range of areas in protein science including understanding the relationship between protein dynamics and function, protein design, protein folding and stability, drug resistance, and determining the structures of proteins by integrating experiments and simulations. The group is part of the Linderstrøm-Lang Centre for Protein Science at the Department of Biology. The research at the centre is highly interdisciplinary ranging from molecular cell biology to protein chemistry, advanced biophysics and computational biology. The centre also has access to state of the art experimental and computational facilities. Project description The PhD students will work on one or more of the subprojects within BRAINSTRUC, focusing on computational methods, both existing and newly developed, together with experimental data to determine the structure and dynamics of complex biomolecules and their assemblies. Experimental data include from SAXS, SANS, Cryo-EM, NMR, X-ray diffraction, and other sources of structural information. For an introduction to the research topic see e.g. our recent review (Bottaro et al, Science, 2018, http: dx.doi.org 10.1126 science.aat4010). Research topics for the PhD projects include: Using coarse-grained and all-atom simulations to study large molecular complexes Using molecular simulations to interpret cryoEM experiments Integrative methods to study intrinsically disordered proteins Principal supervisor is Professor Kresten Lindorff-Larsen, Linderstrøm-Lang Centre for Protein Science and Structural Biology and NMR Laboratory Department of Biology, lindorff@bio.ku.dk. Job description The position is available for a 3-year period and your key tasks as a PhD student at SCIENCE are: To manage and carry through your research project Attend PhD courses Write scientific articles and your PhD thesis Teach and disseminate your research To stay at an external research institution for a few months Work for the department Qualifications We are seeking motivated and strong applicants with a MSc degree in biophysics, physics, chemistry or biochemistry or similar fields. The ideal candidate has with documented research experience within the area of biomolecular simulation. Experience with methods that integrate experimental data and computation will be a strong plus, as will simulations of large molecular assemblies. Experience with working with membrane proteins is also a plus. Candidates must have good interpersonal and communication skills. Fluency in spoken and written English is a requirement. Terms of employment The position is covered by the Memorandum on Job Structure for Academic Staff. Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. The starting salary is currently at a minimum DKK 325.625 (approx. €43,400) including annual supplement ( pension up to DKK 44,980). Negotiation for salary supplement is possible. Application Procedure The application, in English, must be submitted electronically by clicking APPLY NOW below. Please include A cover letter (max 1. page) explaining your background, key skills and how they are relevant to the research in BRAINSTRUC, and your motivation for applying Curriculum vitae (max 2. pages) including educational background previous research experience List of publications (including preprints and papers in review) Diploma and transcripts of records (BSc and MSc) Contact details for two former employers or supervisors (no reference letters should be attached) The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background. The deadline for applications is 19th July 2019 23:59 GMT 2. After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. Afterwards an assessment committee will be appointed to evaluate the selected applications. The applicants will be notified of the composition of the committee and the final selection of a successful candidate will be made by the Head of Department, based on the recommendations of the assessment committee and the interview committee. The main criterion for selection will be the research potential of the applicant and the above mentioned skills. The successful candidate will then be requested to formally apply for enrolment as a PhD student at the PhD school of Science. You can read more about the recruitment process at http: employment.ku.dk faculty recruitment-process . Questions For specific information about the PhD scholarship, please contact the principal supervisor Professor Kresten Lindorff-Larsen, Linderstrøm-Lang Centre for Protein Science and Structural Biology and NMR Laboratory Department of Biology, lindorff@bio.ku.dk. General information about PhD programmes at SCIENCE is available at http: www.science.ku.dk phd.11jobnetc9f5e1a7100000000000IDK_OFIR_02DKDanmark228DKK2019-07-19T00:00:000000https://candidate.hr-manager.net/ApplicationInit.aspx?cid=1307&ProjectId=149800&DepartmentId=18965&MediaId=4632&SkipAdvertisement=true0EuropaDanmarkSjælland & øerStorkøbenhavnKøbenhavnEuropaDanmarkSjælland & øerStorkøbenhavnFrederiksberg3552318KU - SCIENCE BIO - BRIC11Ole Maaløes Vej 52200København NDKDanmark0DKDanmarkDKDanmark8Fuldtid47Tidsbegrænset783300JobNet5009200500920010025-06-20190https://dispatcher.ofir.dk/statistic/register?context=FeedEntrySearchedCount&feedId=dc2beb84&entryId=c9f5e1a7https://dispatcher.ofir.dk/statistic/register?context=FeedEntryDisplayCount&feedId=dc2beb84&entryId=c9f5e1a7https://dispatcher.ofir.dk/statistic/register?context=JobApplicationInitiatedCount&feedId=dc2beb84&entryId=c9f5e1a7&page=ShowJob&component=SendApplicationButtonhttps://dispatcher.ofir.dk/statistic/register?context=JobApplicationAppliedCount&feedId=dc2beb84&entryId=c9f5e1a7&page=EmailApplyForm&component=SendApplicationButtonhttps://static.matchwork.com/company/logo/DK/ORS/SoMe/IT_Ingenioer_og_energi/Ingenioer_og_naturvidenskab/2.jpgMed et job indenfor Ingeniør og naturvidenskab får du en spændende hverdag, der byder på mange nye udfordringer. 12008071Dansk3Læse/ tale221101Biolog20Ingeniør og naturvidenskab362135340noreply@ofir.comDKDanmarkDKDanmarkda-DK