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PhD fellow in single molecule biophysics

Department of Chemistry, Faculty of Science at University of Copenhagen is offering a PhD scholarship in Single molecule biophysics commencing 1st April or as soon as possible thereafter.  
 
Description of the scientific environment  
The position is in the Group of Asoc. Prof Nikos S. Hatzakis at the Department of Chemistry, University of Copenhagen. The main interest of the group is to develop and optimize methods, which through single molecules studies, can provide a fundamental understanding of the molecular mechanistic detail underlying protein function.  
 
Project description  
The PhD student will be tasked with the development, optimization and use of single particle assays to quantify protein-ligand (oligosaccharides, small molecule inhibitors) interactions using fluorescent microscopy techniques like TIRF, FLIM, confocal microscopy. The project lies in the interface of physics and chemistry and glycobiology and requires extensive statistical analysis. The student will aim to quantify the transient interaction of the proteins with ligand and decipher how regulatory cues, like changes in pH, ionic strength, or ligand properties, regulate these interactions. During the project, the student is expected to both perform the single particle experiments and treat the high quality data and as such will be tasked with developing, assessing and optimizing software suitable for treatment of large datasets. The results will be crucial for attaining a fundamental understanding of protein ligand interactions, which provide key features for protein design or in silico drug design, and will be important for applications with industrial partners like Biotech and pharmaceutical companies as well as medical doctors.  
 
The group currently consist of 10 persons (1 Asoc. Prof, 2 post Docs, 5PhDs and 3 MSc)  
 
Principal supervisor is Associate professor, Nikos S. Hatzakis, Department of Chemistry, Hatzakis@chem.ku.dk  Direct Phone: 0045 35334502  
 
Job description  
The position is available for 3 year and your key tasks as a PhD student at SCIENCE are:  
• To manage and carry through your research project  
• Attend PhD courses  
• Write scientific articles and your PhD thesis  
• Teach and disseminate your research  
• To stay at an external research institution for a few months, preferably abroad  
• Work for the department  
 
Formal requirements  
Applicants should either hold an MSc degree in Physics, Nanoscience, or similar fields with great results and excellent English communication skills.  
 
In order to be considered for the position the applicants should have :  
• Extensive expertise in fluorescent microscopy (TIRF and confocal), single particle techniques and FRET measurements  
• Documented experience with writing and understanding scientific software including Matlab and python for quantitative image analysis and treating large datasets  
• Extensive expertise in protein ligand interactions by single particle tracking studies  
• Expertise with model membrane systems, such as liposomes and how to image them using fluorescent microscopy  
• Experience with enzymes conjugation and purification using eg FPLC  
• Comprehensive knowledge about glycosidases, lectins triglycerides, lipids, bilayers and liposomes  
• Fluency in English and excellent communication skills  
• Experience in teaching and supervising  
Terms of employment  
The position is covered by the Memorandum on Job Structure for Academic Staff.  
Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.  
 
The starting salary is currently at a minimum DKK 312.879 including annual supplement (+ pension up to DKK 43.219). Negotiation for salary supplement is possible.  
 
Application Procedure  
The application, in English, must be submitted electronically by clicking APPLY NOW below.  
 
Please include  
• Cover Letter, max 0.5 pages detailing your motivation and background for applying for the specific PhD project  
• CV  
• Diploma and transcripts of records (BSc and MSc) or letter confirming the graduation within 15 days of deadline  
• Other information for consideration, e.g. list of publications, patents (if any)  
• Full contact details (Name, address, telephone & email) of 1-3 professional referees  
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.  
 
The deadline for applications is February 25th, 2018, 23:59 GMT +1. Applications received after the deadline for applications will not be considered.  
 
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. Afterwards an assessment committee will be appointed to evaluate the selected applications. The applicants will be notified of the composition of the committee and the final selection of a successful candidate will be made by the Head of Department, based on the recommendations of the assessment committee and the interview committee.  
 
The main criterion for selection will be the research potential of the applicant and the above mentioned skills. The successful candidate will then be requested to formally apply for enrolment as a PhD student at the PhD school of Science. You can read more about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/.  
 
Questions  
For specific information about the PhD scholarship, please contact the principal supervisor Associate professor Nikos S. Hatzakis, Department of Chemistry Hatzakis@chem.ku.dk  Direct Phone: 35334502].  
 
General information about PhD programs at SCIENCE is available at http://www.science.ku.dk/phd  
 
 
 


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