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PhD fellowship at Department of Nuclear Medicine & PET Centre - Investigation of ''dual-hit'' hypothesis in Parkinson´s disease pathology

The PhD fellowship consists of supervised research, combined with courses and other educational activities. An individual study plan is established for each doctoral student. For a doctoral degree, the equivalent of three years of full-time doctoral education is required.

The Department of Nuclear Medicine and PET Center at the Department of Clinical Medicine, HEALTH, Aarhus University is offering a PhD fellowship commencing on 1st September 2019 or soon thereafter.

The application deadline is 15th July 2019.

We are seeking a candidate with a background within neuroscience, medicine, biomedicine or (bio)medical engineering and ideally with some previous research experience within the field of neurodegenerative disorders. The candidate should be interested in developing a career in neuroscience.

The research group of prof. Per Borghammer has funding available for a 3 year PhD position in Parkinson’s disease (PD) research at the Department of Nuclear Medicine & PET at Aarhus University. The research group is part of the PET Centre at Aarhus University Hospital, which focuses on developing and using imaging biomarkers to understand the mechanisms of neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease.

The PET Centre is located at the Danish Neuroscience Centre (DNC), which also houses Functional Neuroimaging, Neurology, Neurosurgery, and Psychology researchers, Neuropathology and Stereology, as well as animal PET/MRI and animal holding facilities. Because we take part in clinical trial studies and collaborate with basic scientists, the Nuclear Medicine department at Aarhus University provides an excellent research environment.

The successful applicant will join a team consisting of post-docs, PhD students and master students. The future PhD fellow will participate actively in this network and collaborate with a range of professionals, including basic scientists, physicists and radiochemists, clinical investigators, lab technicians, etc.

Project Description
The cause of Parkinson’s disease (PD) is still unknown, but it has been hypothesized that pathological alpha-synuclein (asyn) protein initially forms in the olfactory bulb and in gut nerve terminals and then travels via autonomic nerves to the brainstem. This ‘’dual-hit’’ hypothesis is supported by evidence from patient tissues, epidemiology, and animal models. Recent studies suggest that the microbiome and gut inflammation is implicated in the pathogenesis, but exact mechanisms are unknown.
Our present research focuses on the clinical and preclinical investigation of the ‘’dual-hit’’-hypothesis in PD pathogenesis. And, we have shown a bidirectional and trans-synaptic spread of asyn pathology through the peripheral connectome from gut to brain in rodent models of PD.

The current project will further address the question, whether PD starts in the gut - and through which mechanisms by: (1) using rodent models of PD to further investigate gut-to-brain spreading of pathology and (2) performing histology studies of archived gut tissue removed from PD patients prior to diagnosis. This project is embedded within a larger project where extensive imaging-based phenotyping of prodromal and diagnosed PD patients will be performed in order to obtain correlations to objective measures of gut pathology and microbiome characteristics. This project is done in collaboration with pathologists and clinicians to translate our findings to clinically applicable results.

The project is funded by the Lundbeck Foundation.

Principal supervisor
Per Borghammer, MD, Ph.D, D.M.Sc
Aarhus University Hospital, Denmark
Department of Nuclear Medicine and PET
Email: perborgh@rm.dk

Area of responsibilities/description of the work

Skills and personal qualities
The candidate must have a master's degree in medicine, biomedicine, neuroscience, biology, or (bio)medical engineering. He or she should have a strong and documented interest in neuroscience, with preferably some research experience within neurodegenerative disorders. We are looking for a highly motivated and talented individual that can actively contribute with own ideas and proposals for experimental designs. Proficiency in oral and written English is necessary, as are good social skills. Experience with histology or other relevant practical experience is preferred, but not required.

General job description
Your key tasks as a PhD fellow at the Department of Nuclear Medicine and PET center are to:

  • Manage and carry through your research project.
  • Take PhD courses.
  • Teach and disseminate your research.
  • Write scientific articles and your PhD thesis.

The PhD project will be take place at Department of Nuclear Medicine and PET center, located in the new University hospital building in Skejby, Palle Juul-Jensens Boulevard 165 (Entrance J), 8200 Aarhus N.

Formal requirements
The position is available for a 3-year period for applicants holding a relevant degree. The chosen candidate will have to apply for enrolment in one of the four annual application rounds at the Graduate School of Health, Aarhus University. It is a requirement that both the candidate and the project are accepted for enrolment to be able to start the PhD fellowship.

Terms of employment
The doctoral student will receive financial support during his or her doctoral education in the form of an employment contract. Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organisations.

The position is covered by the Job Structure for Academic Staff at Universities (2007). For further information, please contact Dr. Nathalie Van Den Berge, PhD on nathalie.vandenberge@clin.au.dk

Application procedure
Please send your motivated application by email to Research Coordinator Michele Gammeltoft michgamm@rm.dk and include a personal letter and CV, diploma and transcript of records, at least one recommendation, and any other documentation showing the desirable skills and personal qualities described above. These documents should be in Danish or English.
Applications must be received no later than 15th July 2019.

Selection
A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.
AU uses the following bases of assessment:
  • Documented subject knowledge of relevance to the area of research
  • Analytical skill
  • Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

Top-ranked applicants will be interviewed in Aarhus.

Aarhus University
Aarhus University is an academically diverse and research-intensive university with a strong commitment to high-quality research and education and the development of society nationally and globally. The university offers an inspiring research and teaching environment to its 39,000 students (FTEs) and 8,000 employees, and has an annual revenues of EUR 884 million. Learn more at www.au.dk/en

Deadline:
15 July 2019

 


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330035338Phoenix-1c9cc7fd12019-06-26T00:00:00PhD fellowship at Department of Nuclear Medicine & PET Centre - Investigation of ''dual-hit'' hypothesis in Parkinson´s disease pathologyThe PhD fellowship consists of supervised research, combined with courses and other educational activities. An individual study plan is established for each doctoral student. For a doctoral degree, the equivalent of three years of full-time doctoral education is required.

The Department of Nuclear Medicine and PET Center at the Department of Clinical Medicine, HEALTH, Aarhus University is offering a PhD fellowship commencing on 1st September 2019 or soon thereafter.

The application deadline is 15th July 2019.

We are seeking a candidate with a background within neuroscience, medicine, biomedicine or (bio)medical engineering and ideally with some previous research experience within the field of neurodegenerative disorders. The candidate should be interested in developing a career in neuroscience.

The research group of prof. Per Borghammer has funding available for a 3 year PhD position in Parkinson’s disease (PD) research at the Department of Nuclear Medicine & PET at Aarhus University. The research group is part of the PET Centre at Aarhus University Hospital, which focuses on developing and using imaging biomarkers to understand the mechanisms of neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease.

The PET Centre is located at the Danish Neuroscience Centre (DNC), which also houses Functional Neuroimaging, Neurology, Neurosurgery, and Psychology researchers, Neuropathology and Stereology, as well as animal PET/MRI and animal holding facilities. Because we take part in clinical trial studies and collaborate with basic scientists, the Nuclear Medicine department at Aarhus University provides an excellent research environment.

The successful applicant will join a team consisting of post-docs, PhD students and master students. The future PhD fellow will participate actively in this network and collaborate with a range of professionals, including basic scientists, physicists and radiochemists, clinical investigators, lab technicians, etc.

Project Description
The cause of Parkinson’s disease (PD) is still unknown, but it has been hypothesized that pathological alpha-synuclein (asyn) protein initially forms in the olfactory bulb and in gut nerve terminals and then travels via autonomic nerves to the brainstem. This ‘’dual-hit’’ hypothesis is supported by evidence from patient tissues, epidemiology, and animal models. Recent studies suggest that the microbiome and gut inflammation is implicated in the pathogenesis, but exact mechanisms are unknown.
Our present research focuses on the clinical and preclinical investigation of the ‘’dual-hit’’-hypothesis in PD pathogenesis. And, we have shown a bidirectional and trans-synaptic spread of asyn pathology through the peripheral connectome from gut to brain in rodent models of PD.

The current project will further address the question, whether PD starts in the gut - and through which mechanisms by: (1) using rodent models of PD to further investigate gut-to-brain spreading of pathology and (2) performing histology studies of archived gut tissue removed from PD patients prior to diagnosis. This project is embedded within a larger project where extensive imaging-based phenotyping of prodromal and diagnosed PD patients will be performed in order to obtain correlations to objective measures of gut pathology and microbiome characteristics. This project is done in collaboration with pathologists and clinicians to translate our findings to clinically applicable results.

The project is funded by the Lundbeck Foundation.

Principal supervisor
Per Borghammer, MD, Ph.D, D.M.Sc
Aarhus University Hospital, Denmark
Department of Nuclear Medicine and PET
Email: perborgh@rm.dk

Area of responsibilities/description of the work

Skills and personal qualities
The candidate must have a master's degree in medicine, biomedicine, neuroscience, biology, or (bio)medical engineering. He or she should have a strong and documented interest in neuroscience, with preferably some research experience within neurodegenerative disorders. We are looking for a highly motivated and talented individual that can actively contribute with own ideas and proposals for experimental designs. Proficiency in oral and written English is necessary, as are good social skills. Experience with histology or other relevant practical experience is preferred, but not required.

General job description
Your key tasks as a PhD fellow at the Department of Nuclear Medicine and PET center are to:
  • Manage and carry through your research project.
  • Take PhD courses.
  • Teach and disseminate your research.
  • Write scientific articles and your PhD thesis.

The PhD project will be take place at Department of Nuclear Medicine and PET center, located in the new University hospital building in Skejby, Palle Juul-Jensens Boulevard 165 (Entrance J), 8200 Aarhus N.

Formal requirements
The position is available for a 3-year period for applicants holding a relevant degree. The chosen candidate will have to apply for enrolment in one of the four annual application rounds at the Graduate School of Health, Aarhus University. It is a requirement that both the candidate and the project are accepted for enrolment to be able to start the PhD fellowship.

Terms of employment
The doctoral student will receive financial support during his or her doctoral education in the form of an employment contract. Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organisations.

The position is covered by the Job Structure for Academic Staff at Universities (2007). For further information, please contact Dr. Nathalie Van Den Berge, PhD on nathalie.vandenberge@clin.au.dk

Application procedure
Please send your motivated application by email to Research Coordinator Michele Gammeltoft michgamm@rm.dk and include a personal letter and CV, diploma and transcript of records, at least one recommendation, and any other documentation showing the desirable skills and personal qualities described above. These documents should be in Danish or English.
Applications must be received no later than 15th July 2019.

Selection
A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.
AU uses the following bases of assessment:
  • Documented subject knowledge of relevance to the area of research
  • Analytical skill
  • Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

Top-ranked applicants will be interviewed in Aarhus.

Aarhus University
Aarhus University is an academically diverse and research-intensive university with a strong commitment to high-quality research and education and the development of society nationally and globally. The university offers an inspiring research and teaching environment to its 39,000 students (FTEs) and 8,000 employees, and has an annual revenues of EUR 884 million. Learn more at www.au.dk/en

Deadline:
15 July 2019

 

2019-07-16T00:51:28.303 The PhD fellowship consists of supervised research, combined with courses and other educational activities. An individual study plan is established for each doctoral student. For a doctoral degree, the equivalent of three years of full-time doctoral education is required. The Department of Nuclear Medicine and PET Center at the Department of Clinical Medicine, HEALTH, Aarhus University is offering a PhD fellowship commencing on 1st September 2019 or soon thereafter. The application deadline is 15th July 2019. We are seeking a candidate with a background within neuroscience, medicine, biomedicine or (bio)medical engineering and ideally with some previous research experience within the field of neurodegenerative disorders. The candidate should be interested in developing a career in neuroscience. The research group of prof. Per Borghammer has funding available for a 3 year PhD position in Parkinson s disease (PD) research at the Department of Nuclear Medicine PET at Aarhus University. The research group is part of the PET Centre at Aarhus University Hospital, which focuses on developing and using imaging biomarkers to understand the mechanisms of neurodegenerative disorders such as Alzheimer s and Parkinson s disease. The PET Centre is located at the Danish Neuroscience Centre (DNC), which also houses Functional Neuroimaging, Neurology, Neurosurgery, and Psychology researchers, Neuropathology and Stereology, as well as animal PET MRI and animal holding facilities. Because we take part in clinical trial studies and collaborate with basic scientists, the Nuclear Medicine department at Aarhus University provides an excellent research environment. The successful applicant will join a team consisting of post-docs, PhD students and master students. The future PhD fellow will participate actively in this network and collaborate with a range of professionals, including basic scientists, physicists and radiochemists, clinical investigators, lab technicians, etc. Project Description The cause of Parkinson s disease (PD) is still unknown, but it has been hypothesized that pathological alpha-synuclein (asyn) protein initially forms in the olfactory bulb and in gut nerve terminals and then travels via autonomic nerves to the brainstem. This dual-hit hypothesis is supported by evidence from patient tissues, epidemiology, and animal models. Recent studies suggest that the microbiome and gut inflammation is implicated in the pathogenesis, but exact mechanisms are unknown. Our present research focuses on the clinical and preclinical investigation of the dual-hit -hypothesis in PD pathogenesis. And, we have shown a bidirectional and trans-synaptic spread of asyn pathology through the peripheral connectome from gut to brain in rodent models of PD. The current project will further address the question, whether PD starts in the gut - and through which mechanisms by: (1) using rodent models of PD to further investigate gut-to-brain spreading of pathology and (2) performing histology studies of archived gut tissue removed from PD patients prior to diagnosis. This project is embedded within a larger project where extensive imaging-based phenotyping of prodromal and diagnosed PD patients will be performed in order to obtain correlations to objective measures of gut pathology and microbiome characteristics. This project is done in collaboration with pathologists and clinicians to translate our findings to clinically applicable results. The project is funded by the Lundbeck Foundation. Principal supervisor Per Borghammer, MD, Ph.D, D.M.Sc Aarhus University Hospital, Denmark Department of Nuclear Medicine and PET Email: perborgh@rm.dk Area of responsibilities description of the work Skills and personal qualities The candidate must have a master s degree in medicine, biomedicine, neuroscience, biology, or (bio)medical engineering. He or she should have a strong and documented interest in neuroscience, with preferably some research experience within neurodegenerative disorders. We are looking for a highly motivated and talented individual that can actively contribute with own ideas and proposals for experimental designs. Proficiency in oral and written English is necessary, as are good social skills. Experience with histology or other relevant practical experience is preferred, but not required. General job description Your key tasks as a PhD fellow at the Department of Nuclear Medicine and PET center are to:Manage and carry through your research project.Take PhD courses.Teach and disseminate your research.Write scientific articles and your PhD thesis. The PhD project will be take place at Department of Nuclear Medicine and PET center, located in the new University hospital building in Skejby, Palle Juul-Jensens Boulevard 165 (Entrance J), 8200 Aarhus N. Formal requirements The position is available for a 3-year period for applicants holding a relevant degree. The chosen candidate will have to apply for enrolment in one of the four annual application rounds at the Graduate School of Health, Aarhus University. It is a requirement that both the candidate and the project are accepted for enrolment to be able to start the PhD fellowship. Terms of employment The doctoral student will receive financial support during his or her doctoral education in the form of an employment contract. Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organisations. The position is covered by the Job Structure for Academic Staff at Universities (2007). For further information, please contact Dr. Nathalie Van Den Berge, PhD on nathalie.vandenberge@clin.au.dk Application procedure Please send your motivated application by email to Research Coordinator Michele Gammeltoft michgamm@rm.dk and include a personal letter and CV, diploma and transcript of records, at least one recommendation, and any other documentation showing the desirable skills and personal qualities described above. These documents should be in Danish or English. Applications must be received no later than 15th July 2019. Selection A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis. AU uses the following bases of assessment:Documented subject knowledge of relevance to the area of researchAnalytical skillOther documented knowledge or experience that may be relevant to doctoral studies in the subject. Top-ranked applicants will be interviewed in Aarhus. Aarhus University Aarhus University is an academically diverse and research-intensive university with a strong commitment to high-quality research and education and the development of society nationally and globally. The university offers an inspiring research and teaching environment to its 39,000 students (FTEs) and 8,000 employees, and has an annual revenues of EUR 884 million. Learn more at www.au.dk en Deadline: 15 July 201911jobnet1c9cc7fd100000000000IDK_OFIR_02DKDanmark228DKK2019-07-15T00:00:000000https://au.emply.net/recruitment/vacancyApply.aspx?publishingId=a8b30bee-9def-419e-ba66-118ea40eba580EuropaDanmarkJyllandØstjyllandAarhus3538544Aarhus Universitet11Palle Juul-Jensens Boulevard 998200Aarhus NDKDanmark0DKDanmarkDKDanmark8Fuldtid47Tidsbegrænset770977JobNet4998025499802510031-05-20190https://dispatcher.ofir.dk/statistic/register?context=FeedEntrySearchedCount&feedId=dc2beb84&entryId=1c9cc7fdhttps://dispatcher.ofir.dk/statistic/register?context=FeedEntryDisplayCount&feedId=dc2beb84&entryId=1c9cc7fdhttps://dispatcher.ofir.dk/statistic/register?context=JobApplicationInitiatedCount&feedId=dc2beb84&entryId=1c9cc7fd&page=ShowJob&component=SendApplicationButtonhttps://dispatcher.ofir.dk/statistic/register?context=JobApplicationAppliedCount&feedId=dc2beb84&entryId=1c9cc7fd&page=EmailApplyForm&component=SendApplicationButtonhttps://static.matchwork.com/company/logo/DK/ORS/SoMe/Finans_og_oekonomi/Oekonomi/3.jpgMed et job indenfor Økonomi bliver du mødt af spændende opgaver. Hvis du er interesseret, er jobbet som medarbejder lige noget for dig.12008001Dansk3Læse/ tale3Økonomi361968015Perperborgh@rm.dkDKDanmarkDKDanmarkda-DK