PhD fellowship in Biophysics and Cellular Biology

Department of Drug Design and Pharmacology
Faculty of Health and Medical Sciences (SUND)
University of Copenhagen

Department of Drug Design and Pharmacology is offering a three-year PhD fellowship in biophysics and cellular biology. The PhD fellowship is financed by Dr Céline Galvagnion. The fellowship is available from 1 August 2019 or as soon as possible thereafter.

Project description
Parkinson’s Disease is the second most common neurodegenerative disease and is characterized by the loss of dopaminergic neurons and the presence of protein deposits in the brain of patients. These deposits are mainly composed of the protein a-synuclein but can also contain other molecules such as lipids. Moreover, increasing evidence points towards a link between changes in lipid homeostasis and a-synuclein and PD pathology. However, the mechanism by which these lipid changes may influence the propensity of a-synuclein to form aggregates in the cells and in vivo remains to be addressed.

The advertised research project aims at studying the interplay between changes in lipid metabolism associated with PD and the propensity of a-synuclein to form toxic aggregates in different cellular models of the disease. In particular, lipid changes associated with PD will be investigated in dopaminergic-like cells using biochemical and chemical assays including mass spectrometry analyses. Once identified, the influence of these lipid changes on the lipid-binding and aggregation propensity of a-synuclein will be investigated at the molecular level using a range of biophysical methods including circular dichroism, fluorescence spectroscopy, calorimetry and microscopy.

More information on the research activities of the group can be found here:
https://www.researchgate.net/profile/Celine_Galvagnion
https://orcid.org/0000-0001-9753-3310
https://drug.ku.dk/employees/?pure=en/persons/644238
https://drug.ku.dk/disciplines01/peptides-and-proteins/protein-membrane-interactions-in-health-and-disease/

We are looking for a highly motivated and independent PhD student with an expertise in cellular and molecular biology and an experience with cell culture, RNAi, protein (Western blotting) and RNA analysis (RT-qPCR), immunocytochemistry and confocal microscopy.

Principal supervisor

Dr Céline Galvagnion, Department of Drug Design and Pharmacology,
E-mail: celine.galvagnion@sund.ku.dk, direct phone: +45 3533 7828.
https://drug.ku.dk/disciplines01/peptides-and-proteins/protein-membrane-interactions-in-health-and-disease/

Information about the Department can be found at https://drug.ku.dk/.

Required qualifications
As an applicant you must have:

  • Obtained a Master´s degree in biophysics or cellular biology or related areas prior to the starting date
  • Fluency in English and excellent communication skills
Preferred qualifications
  • biophysics
  • cellular biology
Job description
Your key tasks as a PhD fellow at the Faculty are to:
  • Carry through an independent research project under supervision
  • Write scientific articles and the PhD thesis on the grounds of your research project
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
  • Obtain experience with teaching or other types of dissemination related to your PhD project
  • Participate in the undergraduate teaching of students in pharmaceutical sciences
  • Participate in national and international conferences and scientific meetings
  • Stay at an external research institution, preferably abroad
Key criteria for the assessment of applicants
  • Professional qualifications relevant to the PhD project
  • Relevant work experience
  • Publications
  • The grade point average achieved
  • Other professional activities
  • Language skills
  • The successful applicant is also required to be enterprising and to possess good interpersonal skills
Formal requirements
The position is available for a 3-year period for applicants holding a relevant master´s degree.

The successful applicant will be requested to formally apply for enrolment as a PhD student at the Faculty of Health and Medical Sciences according to the rules stipulated in the Ministerial order on the PhD programme at the universities (PhD order) from the Ministry of Science, Innovation, and Higher Education and the guidelines for the PhD programme at the Faculty of Health and Medical Sciences.

The PhD student is expected to be affiliated to the graduate programme in pharmaceutical sciences, Drug Research Academy.

Terms of employment
The position as a PhD fellow is available for a 3-year period.

Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organizations. Depending on seniority, the monthly salary begins around DKK 26,887 (approx. 3,585 EUR) (taxable) plus pension. The position is covered by the Job Structure for Academic Staff at Universities (2013).

Questions
For further information, applicants may contact the principal supervisor, Céline Galvagnion, e-mail: celine.galvagnion@sund.ku.dk, direct phone: +45 3533 7828 or Administrator Marianne W. Jørgensen, e-mail: marianne.joergensen@sund.ku.dk, direct phone: +45 3533 6449.

For more information on working and living in Denmark visit http://ism.ku.dk (International staff mobility) and https://www.workindenmark.dk.

Application procedure
The application, in English, must be submitted electronically by clicking APPLY NOW below.


Your application must include:
  • Cover letter: Letter stating the interest in and qualifications for the project (max. one page)
  • Full CV
  • Diploma and transcripts of records: Master´s degree diploma (including grade transcripts for bachelor´s and master´s degrees). Applicants with a Master´s degree from abroad should also enclose a short description of the grading scale used
  • Possible publication list
  • Other information to consider: Possible references and recommendations
The deadline for applications is 31 May 2019, at 23:59 GMT.
Please note that only online applications will be accepted. Applications received later than this date will not be considered.

The further process
Shortlist: After the expiry of the deadline for applications, the authorised recruitment manager selects applicants for assessment on the advice of the Appointment Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at http://employment.ku.dk.

Assessment: The selected applications will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities and the University of Copenhagen’s guidelines 2013. The Assessment Committee makes a non-prioritised assessment of the academic qualifications and experience with respect to the mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Please note that the applicant will be contacted if the assessment committee requires further documentation.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.




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330016266Phoenix-dc27f8c512019-05-03T00:00:00PhD fellowship in Biophysics and Cellular BiologyDepartment of Drug Design and Pharmacology
Faculty of Health and Medical Sciences (SUND)
University of Copenhagen

Department of Drug Design and Pharmacology is offering a three-year PhD fellowship in biophysics and cellular biology. The PhD fellowship is financed by Dr Céline Galvagnion. The fellowship is available from 1 August 2019 or as soon as possible thereafter.

Project description
Parkinson’s Disease is the second most common neurodegenerative disease and is characterized by the loss of dopaminergic neurons and the presence of protein deposits in the brain of patients. These deposits are mainly composed of the protein a-synuclein but can also contain other molecules such as lipids. Moreover, increasing evidence points towards a link between changes in lipid homeostasis and a-synuclein and PD pathology. However, the mechanism by which these lipid changes may influence the propensity of a-synuclein to form aggregates in the cells and in vivo remains to be addressed.

The advertised research project aims at studying the interplay between changes in lipid metabolism associated with PD and the propensity of a-synuclein to form toxic aggregates in different cellular models of the disease. In particular, lipid changes associated with PD will be investigated in dopaminergic-like cells using biochemical and chemical assays including mass spectrometry analyses. Once identified, the influence of these lipid changes on the lipid-binding and aggregation propensity of a-synuclein will be investigated at the molecular level using a range of biophysical methods including circular dichroism, fluorescence spectroscopy, calorimetry and microscopy.

More information on the research activities of the group can be found here:
https://www.researchgate.net/profile/Celine_Galvagnion
https://orcid.org/0000-0001-9753-3310
https://drug.ku.dk/employees/?pure=en/persons/644238
https://drug.ku.dk/disciplines01/peptides-and-proteins/protein-membrane-interactions-in-health-and-disease/

We are looking for a highly motivated and independent PhD student with an expertise in cellular and molecular biology and an experience with cell culture, RNAi, protein (Western blotting) and RNA analysis (RT-qPCR), immunocytochemistry and confocal microscopy.

Principal supervisor

Dr Céline Galvagnion, Department of Drug Design and Pharmacology,
E-mail: celine.galvagnion@sund.ku.dk, direct phone: +45 3533 7828.
https://drug.ku.dk/disciplines01/peptides-and-proteins/protein-membrane-interactions-in-health-and-disease/

Information about the Department can be found at https://drug.ku.dk/.

Required qualifications
As an applicant you must have:
  • Obtained a Master´s degree in biophysics or cellular biology or related areas prior to the starting date
  • Fluency in English and excellent communication skills
Preferred qualifications
  • biophysics
  • cellular biology
Job description
Your key tasks as a PhD fellow at the Faculty are to:
  • Carry through an independent research project under supervision
  • Write scientific articles and the PhD thesis on the grounds of your research project
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
  • Obtain experience with teaching or other types of dissemination related to your PhD project
  • Participate in the undergraduate teaching of students in pharmaceutical sciences
  • Participate in national and international conferences and scientific meetings
  • Stay at an external research institution, preferably abroad
Key criteria for the assessment of applicants
  • Professional qualifications relevant to the PhD project
  • Relevant work experience
  • Publications
  • The grade point average achieved
  • Other professional activities
  • Language skills
  • The successful applicant is also required to be enterprising and to possess good interpersonal skills
Formal requirements
The position is available for a 3-year period for applicants holding a relevant master´s degree.

The successful applicant will be requested to formally apply for enrolment as a PhD student at the Faculty of Health and Medical Sciences according to the rules stipulated in the Ministerial order on the PhD programme at the universities (PhD order) from the Ministry of Science, Innovation, and Higher Education and the guidelines for the PhD programme at the Faculty of Health and Medical Sciences.

The PhD student is expected to be affiliated to the graduate programme in pharmaceutical sciences, Drug Research Academy.

Terms of employment
The position as a PhD fellow is available for a 3-year period.

Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organizations. Depending on seniority, the monthly salary begins around DKK 26,887 (approx. 3,585 EUR) (taxable) plus pension. The position is covered by the Job Structure for Academic Staff at Universities (2013).

Questions
For further information, applicants may contact the principal supervisor, Céline Galvagnion, e-mail: celine.galvagnion@sund.ku.dk, direct phone: +45 3533 7828 or Administrator Marianne W. Jørgensen, e-mail: marianne.joergensen@sund.ku.dk, direct phone: +45 3533 6449.

For more information on working and living in Denmark visit http://ism.ku.dk (International staff mobility) and https://www.workindenmark.dk.

Application procedure
The application, in English, must be submitted electronically by clicking APPLY NOW below.


Your application must include:
  • Cover letter: Letter stating the interest in and qualifications for the project (max. one page)
  • Full CV
  • Diploma and transcripts of records: Master´s degree diploma (including grade transcripts for bachelor´s and master´s degrees). Applicants with a Master´s degree from abroad should also enclose a short description of the grading scale used
  • Possible publication list
  • Other information to consider: Possible references and recommendations
The deadline for applications is 31 May 2019, at 23:59 GMT.
Please note that only online applications will be accepted. Applications received later than this date will not be considered.

The further process
Shortlist: After the expiry of the deadline for applications, the authorised recruitment manager selects applicants for assessment on the advice of the Appointment Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at http://employment.ku.dk.

Assessment: The selected applications will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities and the University of Copenhagen’s guidelines 2013. The Assessment Committee makes a non-prioritised assessment of the academic qualifications and experience with respect to the mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Please note that the applicant will be contacted if the assessment committee requires further documentation.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.



Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences (SUND) University of Copenhagen Department of Drug Design and Pharmacology is offering a three-year PhD fellowship in biophysics and cellular biology. The PhD fellowship is financed by Dr Céline Galvagnion. The fellowship is available from 1 August 2019 or as soon as possible thereafter. Project description Parkinson s Disease is the second most common neurodegenerative disease and is characterized by the loss of dopaminergic neurons and the presence of protein deposits in the brain of patients. These deposits are mainly composed of the protein a-synuclein but can also contain other molecules such as lipids. Moreover, increasing evidence points towards a link between changes in lipid homeostasis and a-synuclein and PD pathology. However, the mechanism by which these lipid changes may influence the propensity of a-synuclein to form aggregates in the cells and in vivo remains to be addressed. The advertised research project aims at studying the interplay between changes in lipid metabolism associated with PD and the propensity of a-synuclein to form toxic aggregates in different cellular models of the disease. In particular, lipid changes associated with PD will be investigated in dopaminergic-like cells using biochemical and chemical assays including mass spectrometry analyses. Once identified, the influence of these lipid changes on the lipid-binding and aggregation propensity of a-synuclein will be investigated at the molecular level using a range of biophysical methods including circular dichroism, fluorescence spectroscopy, calorimetry and microscopy. More information on the research activities of the group can be found here: https: www.researchgate.net profile Celine_Galvagnion https: orcid.org 0000-0001-9753-3310 https: drug.ku.dk employees ?pure en persons 644238 https: drug.ku.dk disciplines01 peptides-and-proteins protein-membrane-interactions-in-health-and-disease We are looking for a highly motivated and independent PhD student with an expertise in cellular and molecular biology and an experience with cell culture, RNAi, protein (Western blotting) and RNA analysis (RT-qPCR), immunocytochemistry and confocal microscopy. Principal supervisor Dr Céline Galvagnion, Department of Drug Design and Pharmacology, E-mail: celine.galvagnion@sund.ku.dk, direct phone: 45 3533 7828. https: drug.ku.dk disciplines01 peptides-and-proteins protein-membrane-interactions-in-health-and-disease Information about the Department can be found at https: drug.ku.dk . Required qualifications As an applicant you must have: Obtained a Master´s degree in biophysics or cellular biology or related areas prior to the starting date Fluency in English and excellent communication skills Preferred qualifications biophysics cellular biology Job description Your key tasks as a PhD fellow at the Faculty are to: Carry through an independent research project under supervision Write scientific articles and the PhD thesis on the grounds of your research project Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points Obtain experience with teaching or other types of dissemination related to your PhD project Participate in the undergraduate teaching of students in pharmaceutical sciences Participate in national and international conferences and scientific meetings Stay at an external research institution, preferably abroad Key criteria for the assessment of applicants Professional qualifications relevant to the PhD project Relevant work experience Publications The grade point average achieved Other professional activities Language skills The successful applicant is also required to be enterprising and to possess good interpersonal skills Formal requirements The position is available for a 3-year period for applicants holding a relevant master´s degree. The successful applicant will be requested to formally apply for enrolment as a PhD student at the Faculty of Health and Medical Sciences according to the rules stipulated in the Ministerial order on the PhD programme at the universities (PhD order) from the Ministry of Science, Innovation, and Higher Education and the guidelines for the PhD programme at the Faculty of Health and Medical Sciences. The PhD student is expected to be affiliated to the graduate programme in pharmaceutical sciences, Drug Research Academy. Terms of employment The position as a PhD fellow is available for a 3-year period. Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organizations. Depending on seniority, the monthly salary begins around DKK 26,887 (approx. 3,585 EUR) (taxable) plus pension. The position is covered by the Job Structure for Academic Staff at Universities (2013). Questions For further information, applicants may contact the principal supervisor, Céline Galvagnion, e-mail: celine.galvagnion@sund.ku.dk, direct phone: 45 3533 7828 or Administrator Marianne W. Jørgensen, e-mail: marianne.joergensen@sund.ku.dk, direct phone: 45 3533 6449. For more information on working and living in Denmark visit http: ism.ku.dk (International staff mobility) and https: www.workindenmark.dk. Application procedure The application, in English, must be submitted electronically by clicking APPLY NOW below. Your application must include: Cover letter: Letter stating the interest in and qualifications for the project (max. one page) Full CV Diploma and transcripts of records: Master´s degree diploma (including grade transcripts for bachelor´s and master´s degrees). Applicants with a Master´s degree from abroad should also enclose a short description of the grading scale used Possible publication list Other information to consider: Possible references and recommendations The deadline for applications is 31 May 2019, at 23:59 GMT. Please note that only online applications will be accepted. Applications received later than this date will not be considered. The further process Shortlist: After the expiry of the deadline for applications, the authorised recruitment manager selects applicants for assessment on the advice of the Appointment Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him herself. You can read about the recruitment process at http: employment.ku.dk. Assessment: The selected applications will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities and the University of Copenhagen s guidelines 2013. The Assessment Committee makes a non-prioritised assessment of the academic qualifications and experience with respect to the mentioned area of research, techniques, skills and other requirements listed in the advertisement. Please note that the applicant will be contacted if the assessment committee requires further documentation. University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.11stardc27f8c5100000000000aDK_OFIR_02DKDanmark228DKK2019-05-31T00:00:000000https://candidate.hr-manager.net/ApplicationInit.aspx?cid=1307&ProjectId=149477&DepartmentId=19005&MediaId=4632&SkipAdvertisement=true0EuropaDanmarkSjælland & øerStorkøbenhavnKøbenhavn3519416KU - SUND - Kbh Ø11Jagtvej 1602100København ØDKDanmark0
celine.galvagnion@sund.ku.dkDKDanmarkDKDanmark
8Fuldtid47Tidsbegrænset753606JobNet4982998498299810003-05-20190https://dispatcher.ofir.dk/statistic/register?context=FeedEntrySearchedCount&feedId=dc2beb84&entryId=dc27f8c5https://dispatcher.ofir.dk/statistic/register?context=FeedEntryDisplayCount&feedId=dc2beb84&entryId=dc27f8c5https://dispatcher.ofir.dk/statistic/register?context=JobApplicationInitiatedCount&feedId=dc2beb84&entryId=dc27f8c5&page=ShowJob&component=SendApplicationButtonhttps://dispatcher.ofir.dk/statistic/register?context=JobApplicationAppliedCount&feedId=dc2beb84&entryId=dc27f8c5&page=EmailApplyForm&component=SendApplicationButtonhttps://static.matchwork.com/company/logo/DK/ORS/SoMe/IT_Ingenioer_og_energi/Ingenioer_og_naturvidenskab/4.jpgHos KU - SUND - Kbh Ø søger vi en medarbejder, der er frisk på nye spændende udfordringer.12008001Dansk3Læse/ tale221101Biolog20Ingeniør og naturvidenskab361672236Célineceline.galvagnion@sund.ku.dkDKDanmarkDKDanmark330025881Akademisk medarbejder til kvalitetssikring af stamcelleproduktionRobot Kardiologisk Stamcellecenter, Rigshospitalet En ansættelse som akademisk medarbejder til translationelt stamcelleprojekt er ledig pr. 1. september 2019. Der er tale om en 2-årig ansættelse med mulighed for forlængelse. Kardiologisk Stamcellecenter udvikler og producerer forsøgslægemidler til avanceret terapi indeholdende mesenkymale stromale celler fra fedtvæv. Vores GMP produktionsapparat benytter nyeste teknologi indenfor stamcelleproduktion. Vi leverer celleprodukter til mange forskellige kliniske forsøg, herunder egne kliniske studier af hjertesygdom. Vi søger en naturvidenskabeligt uddannet akademiker (f.eks. biolog, farmaceut eller lignende), som vil tage ansvar for dokumentation af vores GMP-produktion, vedligehold af vores eksisterende kvalitetssystem samt videreudbygning heraf i samarbejde med resten af gruppen. Fra dit tidligere virke har du mindst 3 års erfaring med at arbejde i henhold til GMP, og ideelt har du erfaring med kvalitetssikring i farmaceutisk produktion. Derudover har du praktisk erfaring fra et laboratorium, og du er parat til også at bidrage i det praktiske arbejde under produktionen af vores celleprodukt. Du har et stort fagligt engagement og imødekommenhed overfor varierende arbejdstider. Du skal være med til at sikre, at vores produktion opfylder gældende Europæisk standard for kvalitet af Advanced Therapy Medicinal Products . Dette vil indeholde opgaver som: Ajourføring af gældende lovgivning på området Implementing af Quality Risk Management Identifikation, indsamling og evaluering af kvalitetsdata Formulering af kvalitetsstandarder og procedurer Udarbejdelse af afvigelsesrapporter, risikoanalyser, udviklingsrapporter Dokumentation af træning af personale, kvalificering og vedligehold af apparatur Udarbejdelse af rekommandationer til korrigerende og forebyggende handlinger Udformning og eksekvering af valideringsplaner Afholdelse og dokumentation af interne og eksterne audits Forbedring af eksisterende kvalitetssikringssystem Deltagelse i videreudvikling af vores produktionsproces og kvalitetskontrol Vi mener, at for at kunne løfte ovenstående opgaver, er et tilbundsgående kendskab til selve produktionsprocessen nødvendigt. Vi forventer derfor, at du periodevist er klar til selv at gå med i produktionen så du, i samarbejde med det øvrige produktions-team, kan sikre høj kvalitet af vores produkt. Vi forventer, at du er systematisk og omhyggelig og har forståelse for kvalitetsarbejde. Til gengæld tilbyder vi et job hvor du får lov til at prøve kræfter med mange forskellige discipliner. På Kardiologisk Stamcellecenter arbejder vi i front af klinisk stamcellebehandling, - det kræver gåpåmod og kreativitet, men belønnes med stort ansvar og indflydelse på opgaveløsningen. Vi er en gruppe af dedikerede forskere, - læger, cand.scient er, bioanalytikere og sygeplejersker, med et tæt og stærkt tværfagligt samarbejde. Vi har alle mange forskelligartede funktioner og sætter en stor ære i at løfte i flok. Har du lyst til at være med i spidsen af dansk translationel og klinisk stamcelleforskning, hvor udfordringerne er store og tempoet højt, - men engagementet overstiger begge? Så send en ansøgningen så vi har den i hænde senest 17. Juni 2019. Løn og ansættelsesforhold i henhold til gældende overenskomst. Yderligere oplysninger om stillingen fås ved henvendelse hos professor dr. med Jens Kastrup, Kardiologisk Laboratorium 2014, Rigshospitalet, tlf. 35 45 28 19 eller laboratorieleder Annette Ekblond, Kardiologisk Stamcellelaboratorium 9302, Rigshospitalet, tlf. 35 45 67 30. Rigshospitalet er en røgfri arbejdsplads Kardiologisk Stamcellecenter, Rigshospitalet


En ansættelse som akademisk medarbejder til translationelt stamcelleprojekt er ledig pr. 1. september 2019. Der er tale om en 2-årig ansættelse med mulighed for forlængelse.

Kardiologisk Stamcellecenter udvikler og producerer forsøgslægemidler til avanceret terapi indeholdende mesenkymale stromale celler fra fedtvæv. Vores GMP produktionsapparat benytter nyeste teknologi indenfor stamcelleproduktion. Vi leverer celleprodukter til mange forskellige kliniske forsøg, herunder egne kliniske studier af hjertesygdom.

Vi søger en naturvidenskabeligt uddannet akademiker (f.eks. biolog, farmaceut eller lignende), som vil tage ansvar for dokumentation af vores GMP-produktion, vedligehold af vores eksisterende kvalitetssystem samt videreudbygning heraf i samarbejde med resten af gruppen.

Fra dit tidligere virke har du mindst 3 års erfaring med at arbejde i henhold til GMP, og ideelt har du erfaring med kvalitetssikring i farmaceutisk produktion. Derudover har du praktisk erfaring fra et laboratorium, og du er parat til også at bidrage i det praktiske arbejde under produktionen af vores celleprodukt. Du har et stort fagligt engagement og imødekommenhed overfor varierende arbejdstider.

Du skal være med til at sikre, at vores produktion opfylder gældende Europæisk standard for kvalitet af ”Advanced Therapy Medicinal Products”.

Dette vil indeholde opgaver som:
  • Ajourføring af gældende lovgivning på området
  • Implementing af Quality Risk Management
  • Identifikation, indsamling og evaluering af kvalitetsdata
  • Formulering af kvalitetsstandarder og procedurer
  • Udarbejdelse af afvigelsesrapporter, risikoanalyser, udviklingsrapporter
  • Dokumentation af træning af personale, kvalificering og vedligehold af apparatur
  • Udarbejdelse af rekommandationer til korrigerende og forebyggende handlinger
  • Udformning og eksekvering af valideringsplaner
  • Afholdelse og dokumentation af interne og eksterne audits
  • Forbedring af eksisterende kvalitetssikringssystem
  • Deltagelse i videreudvikling af vores produktionsproces og kvalitetskontrol
Vi mener, at for at kunne løfte ovenstående opgaver, er et tilbundsgående kendskab til selve produktionsprocessen nødvendigt. Vi forventer derfor, at du periodevist er klar til selv at gå med i produktionen så du, i samarbejde med det øvrige produktions-team, kan sikre høj kvalitet af vores produkt.

Vi forventer, at du er systematisk og omhyggelig og har forståelse for kvalitetsarbejde. Til gengæld tilbyder vi et job hvor du får lov til at prøve kræfter med mange forskellige discipliner.

På Kardiologisk Stamcellecenter arbejder vi i front af klinisk stamcellebehandling, - det kræver gåpåmod og kreativitet, men belønnes med stort ansvar og indflydelse på opgaveløsningen.

Vi er en gruppe af dedikerede forskere, - læger, cand.scient’er, bioanalytikere og sygeplejersker, med et tæt og stærkt tværfagligt samarbejde. Vi har alle mange forskelligartede funktioner og sætter en stor ære i at løfte i flok.

Har du lyst til at være med i spidsen af dansk translationel og klinisk stamcelleforskning, hvor udfordringerne er store og tempoet højt, - men engagementet overstiger begge?

Så send en ansøgningen så vi har den i hænde senest 17. Juni 2019.

Løn og ansættelsesforhold i henhold til gældende overenskomst.

Yderligere oplysninger om stillingen fås ved henvendelse hos professor dr. med Jens Kastrup, Kardiologisk Laboratorium 2014, Rigshospitalet, tlf. 35 45 28 19 eller laboratorieleder Annette Ekblond, Kardiologisk Stamcellelaboratorium 9302, Rigshospitalet, tlf. 35 45 67 30.

”Rigshospitalet er en røgfri arbejdsplads”






RigshospitaletKøbenhavn Ø2019-05-16T00:00:002019-06-17T00:00:00
330023848Postdoc in identifying intra- and inter-organ signaling pathways regulating adult gut homeostasis, Department of BiologyRobot Department of Biology at the Faculty of Science, University of Copenhagen is offering a Postdoc position in Biology commencing 1st of February 2020 or as soon as possible thereafter. Description of the scientific environment The Andersen-Colombani group at the Department of Biology, University of Copenhagen, is recruiting a Postdoc to work on a 2-year project aiming at understanding the mechanisms controlling intestinal stem cell proliferation and gut homeostasis and pathologies using Drosophila Melanogaster as a model organism. The position is available to start on 1st of February 2020 or as soon as possible thereafter. The group is housed in the section of Cell and Neurobiology at the Department of Biology (https: www.biocenter.ku.dk ) and affiliated with the Danstem Center (https: danstem.ku.dk ). Background The intestine, which represents one of the largest interfaces with the external environment, plays a key role in relaying environmental inputs to other organs to produce systemic responses. In turn, the gut is subject to multiple regulatory inputs from the brain, muscles, liver and adipose tissues. At steady-state turnover rates, the human intestine undergoes complete self-renewal every 4-5 days, a process which is highly accelerated in response to damage of the gut epithelium. This capacity for self-renewal relies on the proliferative activity of the intestinal stem cells (ISCs), which is tightly controlled by multiple local and systemic signals released from neighboring cell populations (the ISC niche) and non-gastrointestinal organs. Despite the physiological divergence between insects and mammals, studies have shown that flies represent a model that is well suited for studying stem cell physiology during ageing, stress, and infection. Our team is interested in identifying the intra- and inter-organ couplings contributing to gut homeostasis and disease. Project Description The project advertised here aims at identifying local and systemic signals controlling intestinal stem cell proliferation and gut homeostasis. For this purpose, RNAis will be used to known down all genes encoding receptors specifically in the stem cell niche, which plays an important role in integrating local and systemic signals to control intestinal stem cell proliferation. Sensitivity to oral infection with the gram-negative bacteria, Ecc15, will be used as readout to identify niche-derived signals required for ISC-driven intestinal regenerative growth. The potential of the identified signals to control ISC proliferation during homeostasis and disease will be studied. Since large-scale functional approaches are not feasible in vertebrate, this project could reveal novel couplings contributing to mammalian gastrointestinal homeostasis and disease. The postdoc s duties will include working on the project described here as well as teaching. We are looking for highly motivated individuals with a PhD degree in Biology and with prior experience in fly physiology and genetics. Qualifications Selection criteria Applicants should hold a PhD degree in Biology Having prior experience with the Drosophila model and Genetics is essential Having a solid background in Physiology is an advantage Strong motivation and very good scientific skills are essential Good communication skills, oral and written Terms of employment The position is covered by the Memorandum on Job Structure for Academic Staff. Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. The starting salary is currently up to DKK 430,570 including annual supplement ( pension up to DKK 73,627). Negotiation for salary supplement is possible. The application, in English, must be submitted electronically by clicking APPLY NOW below. Please include Curriculum vita Diplomas (Master and PhD degree) Research plan description of current and future research plans Complete publication list Separate reprints of 3 particularly relevant papers The deadline for applications is Wednesday 29 May 2019, 23:59 GMT 2. After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background. Further information on the Department is linked at http: www.science.ku.dk english about-the-faculty organisation . Inquiries about the position can be made to Dr. Ditte Andersen, ditte.andersen@bio.ku.dk, direct Phone: 45 27 85 30 22 or Dr. Julien Colombani, julien.colombani@bio.ku.dk, direct Phone: 45 27 84 76 66. You can read about the recruitment process at http: employment.ku.dk faculty recruitment-process .Department of Biology at the Faculty of Science, University of Copenhagen is offering a Postdoc position in Biology commencing 1st of February 2020 or as soon as possible thereafter.

Description of the scientific environment
The Andersen-Colombani group at the Department of Biology, University of Copenhagen, is recruiting a Postdoc to work on a 2-year project aiming at understanding the mechanisms controlling intestinal stem cell proliferation and gut homeostasis and pathologies using Drosophila Melanogaster as a model organism. The position is available to start on 1st of February 2020 or as soon as possible thereafter. The group is housed in the section of Cell and Neurobiology at the Department of Biology (https://www.biocenter.ku.dk/) and affiliated with the Danstem Center (https://danstem.ku.dk/).

Background
The intestine, which represents one of the largest interfaces with the external environment, plays a key role in relaying environmental inputs to other organs to produce systemic responses. In turn, the gut is subject to multiple regulatory inputs from the brain, muscles, liver and adipose tissues. At steady-state turnover rates, the human intestine undergoes complete self-renewal every 4-5 days, a process which is highly accelerated in response to damage of the gut epithelium. This capacity for self-renewal relies on the proliferative activity of the intestinal stem cells (ISCs), which is tightly controlled by multiple local and systemic signals released from neighboring cell populations (the ISC niche) and non-gastrointestinal organs. Despite the physiological divergence between insects and mammals, studies have shown that flies represent a model that is well suited for studying stem cell physiology during ageing, stress, and infection. Our team is interested in identifying the intra- and inter-organ couplings contributing to gut homeostasis and disease.

Project Description
The project advertised here aims at identifying local and systemic signals controlling intestinal stem cell proliferation and gut homeostasis. For this purpose, RNAis will be used to known down all genes encoding receptors specifically in the stem cell niche, which plays an important role in integrating local and systemic signals to control intestinal stem cell proliferation. Sensitivity to oral infection with the gram-negative bacteria, Ecc15, will be used as readout to identify niche-derived signals required for ISC-driven intestinal regenerative growth. The potential of the identified signals to control ISC proliferation during homeostasis and disease will be studied. Since large-scale functional approaches are not feasible in vertebrate, this project could reveal novel couplings contributing to mammalian gastrointestinal homeostasis and disease. The postdoc’s duties will include working on the project described here as well as teaching.

We are looking for highly motivated individuals with a PhD degree in Biology and with prior experience in fly physiology and genetics.

Qualifications/Selection criteria
  • Applicants should hold a PhD degree in Biology
  • Having prior experience with the Drosophila model and Genetics is essential
  • Having a solid background in Physiology is an advantage
  • Strong motivation and very good scientific skills are essential
  • Good communication skills, oral and written
Terms of employment
The position is covered by the Memorandum on Job Structure for Academic Staff.

Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.

The starting salary is currently up to DKK 430,570 including annual supplement (+ pension up to DKK 73,627). Negotiation for salary supplement is possible.

The application, in English, must be submitted electronically by clicking APPLY NOW below.

Please include
  • Curriculum vita
  • Diplomas (Master and PhD degree)
  • Research plan – description of current and future research plans
  • Complete publication list
  • Separate reprints of 3 particularly relevant papers
The deadline for applications is Wednesday 29 May 2019, 23:59 GMT +2.

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee.

The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

Further information on the Department is linked at http://www.science.ku.dk/english/about-the-faculty/organisation/. Inquiries about the position can be made to Dr. Ditte Andersen, ditte.andersen@bio.ku.dk, direct Phone: +45 27 85 30 22 or Dr. Julien Colombani, julien.colombani@bio.ku.dk, direct Phone: +45 27 84 76 66.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/.

KU - SCIENCE - BIO SNMKøbenhavn Ø2019-05-14T00:00:002019-05-29T00:00:00
330022948PhD fellow in Plant Molecular BiologyRobot Department of Plant and Environmental Sciences, Faculty of Science at University of Copenhagen is offering a PhD scholarship in Plant Molecular Biology commencing 1 August 2019 or as soon as possible thereafter. Description of the scientific environment The department studies all aspects of plant biology. The research group to which the candidate will be affiliated has a main focus on the molecular biology of primary active transport systems in plants. Project description The project supported by the Carlsberg Foundation aims at understanding the molecular basis for salt tolerance of Chenopodium quinoa. The PhD student will work on characterizing cation transporters in this plant. The work will include making an inventory of putative cation transporters in the genome of C. quinoa and functionally expressing selected transporters in yeast for characterization of their properties. At a later stage of the project the candidate may have the possibility to examine the phenotype of plants carrying mutations in the corresponding genes. Principal supervisor is Professor Michael Palmgren,Department of Plant and Environmental Sciences, E-mail palmgren@plen.ku.dk, Direct Phone: 45 23988444. Job description The position is available for a 3-year period and your key tasks as a PhD student at SCIENCE are: To manage and carry through your research project Attend PhD courses Write scientific articles and your PhD thesis Teach and disseminate your research To stay at an external research institution for a few months, preferably abroad Work for the department Formal requirements Applicants should hold an MSc degree in Biology, Biochemistry or Biotechnology with good results and good English skills. As criteria for the assessment of your qualifications emphasis will also be laid on previous publications (if any) and relevant work experience. Terms of employment The position is covered by the Memorandum on Job Structure for Academic Staff. Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. The starting salary is currently at a minimum DKK 325.625 (approx. €43,400) including annual supplement ( pension up to DKK 44,980). Negotiation for salary supplement is possible. Application Procedure The application, in English, must be submitted electronically by clicking APPLY NOW below. Please include Cover Letter CV Diploma and transcripts of records (BSc and MSc) Acceptance Letter for the relevant MSc Programme at SCIENCE, if any Other information for consideration, e.g. list of publications (if any), Full contact details (Name, address, telephone email) of 1-3 professional referees The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background. The deadline for applications is 31st May 2019, 23:59 GMT 2. After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. Afterwards an assessment committee will be appointed to evaluate the selected applications. The applicants will be notified of the composition of the committee and the final selection of a successful candidate will be made by the Head of Department, based on the recommendations of the assessment committee and the interview committee. The main criterion for selection will be the research potential of the applicant and the above mentioned skills. The successful candidate will then be requested to formally apply for enrolment as a PhD student at the PhD school of Science. You can read more about the recruitment process at http: employment.ku.dk faculty recruitment-process . Questions For specific information about the PhD scholarship, please contact the principal supervisor Professor Michael Palmgren, Department of Plant and Environmental Sciences, e-mail palmgren@plen.ku.dk, direct Phone: 45 23988444. General information about PhD programmes at SCIENCE is available at http: www.science.ku.dk phd.Department of Plant and Environmental Sciences, Faculty of Science at University of Copenhagen is offering a PhD scholarship in Plant Molecular Biology commencing 1 August 2019 or as soon as possible thereafter.

Description of the scientific environment
The department studies all aspects of plant biology. The research group to which the candidate will be affiliated has a main focus on the molecular biology of primary active transport systems in plants.

Project description
The project supported by the Carlsberg Foundation aims at understanding the molecular basis for salt tolerance of Chenopodium quinoa. The PhD student will work on characterizing cation transporters in this plant. The work will include making an inventory of putative cation transporters in the genome of C. quinoa and functionally expressing selected transporters in yeast for characterization of their properties. At a later stage of the project the candidate may have the possibility to examine the phenotype of plants carrying mutations in the corresponding genes.

Principal supervisor is Professor Michael Palmgren,Department of Plant and Environmental Sciences, E-mail palmgren@plen.ku.dk, Direct Phone: +45 23988444.

Job description
The position is available for a 3-year period and your key tasks as a PhD student at SCIENCE are:
  • To manage and carry through your research project
  • Attend PhD courses
  • Write scientific articles and your PhD thesis
  • Teach and disseminate your research
  • To stay at an external research institution for a few months, preferably abroad
  • Work for the department
Formal requirements
Applicants should hold an MSc degree in Biology, Biochemistry or Biotechnology with good results and good English skills. As criteria for the assessment of your qualifications emphasis will also be laid on previous publications (if any) and relevant work experience.

Terms of employment
The position is covered by the Memorandum on Job Structure for Academic Staff.

Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.

The starting salary is currently at a minimum DKK 325.625 (approx. €43,400) including annual supplement (+ pension up to DKK 44,980). Negotiation for salary supplement is possible.

Application Procedure
The application, in English, must be submitted electronically by clicking APPLY NOW below.

Please include
  • Cover Letter
  • CV
  • Diploma and transcripts of records (BSc and MSc)
  • Acceptance Letter for the relevant MSc Programme at SCIENCE, if any
  • Other information for consideration, e.g. list of publications (if any),
  • Full contact details (Name, address, telephone & email) of 1-3 professional referees

The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

The deadline for applications is 31st May 2019, 23:59 GMT +2.

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. Afterwards an assessment committee will be appointed to evaluate the selected applications. The applicants will be notified of the composition of the committee and the final selection of a successful candidate will be made by the Head of Department, based on the recommendations of the assessment committee and the interview committee.
The main criterion for selection will be the research potential of the applicant and the above mentioned skills. The successful candidate will then be requested to formally apply for enrolment as a PhD student at the PhD school of Science. You can read more about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/.

Questions
For specific information about the PhD scholarship, please contact the principal supervisor Professor Michael Palmgren, Department of Plant and Environmental Sciences, e-mail palmgren@plen.ku.dk, direct Phone: +45 23988444.

General information about PhD programmes at SCIENCE is available at http://www.science.ku.dk/phd.
KU - SCIENCE - PLENFrederiksberg C2019-05-13T00:00:002019-05-31T00:00:00
330022110Three Postdoctoral fellowships in data science, bioinformatics or computational biology in human microbiomeRobot We are seeking candidates to fill up to three 2-year positions, with possibilities of extension, to work on computational analysis of multi-omics data from the human gut microbiome. The positions are in the Microbiome Systems Biology group led by Associate Professor Manimozhiyan Arumugam. The starting date is August 1, 2019 or as soon as possible thereafter. Background The Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) was established in 2010 to conduct fundamental research on metabolism. It is part of the Faculty of Health and Medical Sciences, University of Copenhagen. We are a Center of excellence where talented researchers and experienced laboratory technicians is bringing scientific discoveries from the laboratory to the society in an effort to tackle some of today s biggest challenges diabetes and obesity. The Center has around 200 employees from all over the world. Its employees moved into new laboratories, offices and meeting rooms in the Maersk Tower in summer 2017. You can read more about us at http: cbmr.ku.dk The human microbiota, the collection of trillions of microbes inhabiting the human body, has a strong influence on human health and diseases. The Arumugam Group investigates the role of gut microbiota in several diseases including type 2 diabetes, obesity, liver fibrosis, colorectal cancer and multiple sclerosis using human cohorts and animal models. These studies involve integrated analysis of multi-omics data (including metagenomics, metatranscriptomics, metabolomics, host genetics, and host transcriptomics) and clinical metabolic phenotypes to better understand the role of gut microbiota in diseases. The group has access to a high-performance computing cluster with more than 500 CPUs to support these and other computational projects. You can read more about the group at: https: cbmr.ku.dk research human-genomics-and-metagenomics-in-metabolism arumugam-group and http: research.ku.dk search ?pure en persons 441006 Project Description The advertised positions relates to two projects funded by the European Union s Horizon 2020 framework GALAXY and MICROB-PREDICT. GALAXY investigates the gut and liver axis in alcoholic liver fibrosis using host-microbial multi-omics consisting genetics, microRNAs, metabolomics, gut metagenomics (shotgun sequencing), gut metatranscriptomics, in order to identify biomarkers of fibrosis. MICROB-PREDICT investigates the gut-liver axis in late stage liver cirrhosis using host-microbial multi-omics to identify biomarkers for late cirrhosis and predict response to treatment. Successful candidates will be integrating these multi-omics data in collaboration with the work package co-leader European Molecular Biology Laboratory (EMBL-Heidelberg) and other project partners in GALAXY and MICROB-PREDICT. More information about GALAXY can be found at www.livergalaxy.eu More information about MICROB-PREDICT can be found at www.microb-predict.eu Your job The positions are 2-year postdoctoral fellowship positions in computational biology under the supervision of Associate Professor Manimozhiyan Arumugam, where the candidates will be responsible for developing novel tools to analyze microbiome and multi-omics data in the context of alcoholic liver fibrosis and late liver cirrhosis, while also incorporating and improving existing state-of-the-art tools. The candidates are expected to participate in and lead existing projects within GALAXY MICROB-PREDICT and are highly encouraged to initiate new cutting-edge research projects. The candidates are also expected to interact and collaborate with other medical researchers, biologists, and bioinformaticians in the Center, the GALAXY consortium and MICROB-PREDICT consortium, to enhance and ensure proper interpretation of experimental results. Profile In connection with the appointment to the positions, special importance will be attached to applicants having the professional and personal qualifications stated below: PhD in bioinformatics, or in computer science (informatics) with experience in bioinformatics research, or in biology with strong experience in software development Academic preparation as well as experience in machine learning and statistical analysis Experience in handling next-generation sequencing data Strong programming skills in C C , Python or Perl Experience in statistical computing environments such as R Experience in high performance computing environment using any flavor of UNIX An excellent research record exemplified by strong publications Strong communication skills in English, both spoken and written, are essential The following qualifications are highly preferred, but not required. Candidates who possess any of these qualifications are encouraged to highlight them in the application: Basic understanding of human disease biology and or microbiology Experience in analyzing metagenomic datasets from human gut microbiota Experience in handling multi-omics data, including metabolomics and proteomics Experience in distributed and cloud computing technologies Familiarity with bioinformatics programming environments such as BioPython BioPerl Place of employment The place of employment is at Novo Nordisk Foundation Center for Basic Metabolic Research, Maersk Tower, Panum Institute, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Terms of employment The three postdoc positions are full-time positions for 2 years. The starting date is August 1, 2019 or as soon as possible thereafter. Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated. Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years. The positions are covered by the Memorandum on Job Structure for Academic Staff at the Universities of June 28, 2013 Questions For further information, please contact Associate Professor Manimozhiyan Arumugam at arumugam@sund.ku.dk . For questions regarding the recruitment procedure, please contact SUND HR CBMR at mlr@sund.ku.dk . International applicants may find these links useful www.ism.ku.dk (International Staff Mobility) and https: www.workindenmark.dk Application procedure Your online application must be submitted in English by clicking Apply now below. Furthermore your application must include the following documents attachments all in PDF format: A letter of motivation Curriculum vitae Publications list At least two letters of references, maximum four Documentation of research and optionally teaching qualifications Application deadline: June 21 2019, 23.59pm CET We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements. The further process After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him herself. You can read about the recruitment process at http: employment.ku.dk faculty recruitment-process The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities. The University of Copenhagen wishes to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.We are seeking candidates to fill up to three 2-year positions, with possibilities of extension, to work on computational analysis of multi-omics data from the human gut microbiome. The positions are in the Microbiome Systems Biology group led by Associate Professor Manimozhiyan Arumugam. The starting date is August 1, 2019 or as soon as possible thereafter.

Background
The Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) was established in 2010 to conduct fundamental research on metabolism. It is part of the Faculty of Health and Medical Sciences, University of Copenhagen. We are a Center of excellence where talented researchers and experienced laboratory technicians is bringing scientific discoveries from the laboratory to the society in an effort to tackle some of today’s biggest challenges – diabetes and obesity. The Center has around 200 employees from all over the world. Its employees moved into new laboratories, offices and meeting rooms in the Maersk Tower in summer 2017. You can read more about us at http://cbmr.ku.dk

The human microbiota, the collection of trillions of microbes inhabiting the human body, has a strong influence on human health and diseases. The Arumugam Group investigates the role of gut microbiota in several diseases – including type 2 diabetes, obesity, liver fibrosis, colorectal cancer and multiple sclerosis – using human cohorts and animal models. These studies involve integrated analysis of multi-omics data (including metagenomics, metatranscriptomics, metabolomics, host genetics, and host transcriptomics) and clinical/metabolic phenotypes to better understand the role of gut microbiota in diseases. The group has access to a high-performance computing cluster with more than 500 CPUs to support these and other computational projects. You can read more about the group at:
https://cbmr.ku.dk/research/human-genomics-and-metagenomics-in-metabolism/arumugam-group/ and http://research.ku.dk/search/?pure=en/persons/441006

Project Description
The advertised positions relates to two projects funded by the European Union’s Horizon 2020 framework – GALAXY and MICROB-PREDICT. GALAXY investigates the gut and liver axis in alcoholic liver fibrosis using host-microbial multi-omics consisting genetics, microRNAs, metabolomics, gut metagenomics (shotgun sequencing), gut metatranscriptomics, in order to identify biomarkers of fibrosis. MICROB-PREDICT investigates the gut-liver axis in late stage liver cirrhosis using host-microbial multi-omics to identify biomarkers for late cirrhosis and predict response to treatment. Successful candidates will be integrating these multi-omics data in collaboration with the work package co-leader European Molecular Biology Laboratory (EMBL-Heidelberg) and other project partners in GALAXY and MICROB-PREDICT.

More information about GALAXY can be found at www.livergalaxy.eu
More information about MICROB-PREDICT can be found at www.microb-predict.eu

Your job
The positions are 2-year postdoctoral fellowship positions in computational biology under the supervision of Associate Professor Manimozhiyan Arumugam, where the candidates will be responsible for developing novel tools to analyze microbiome and multi-omics data in the context of alcoholic liver fibrosis and late liver cirrhosis, while also incorporating and improving existing state-of-the-art tools. The candidates are expected to participate in and lead existing projects within GALAXY/MICROB-PREDICT; and are highly encouraged to initiate new cutting-edge research projects. The candidates are also expected to interact and collaborate with other medical researchers, biologists, and bioinformaticians in the Center, the GALAXY consortium and MICROB-PREDICT consortium, to enhance and ensure proper interpretation of experimental results.

Profile
In connection with the appointment to the positions, special importance will be attached to applicants having the professional and personal qualifications stated below:

  • PhD in bioinformatics, or in computer science (informatics) with experience in bioinformatics research, or in biology with strong experience in software development
  • Academic preparation as well as experience in machine learning and statistical analysis
  • Experience in handling next-generation sequencing data
  • Strong programming skills in C/C++, Python or Perl
  • Experience in statistical computing environments such as R
  • Experience in high performance computing environment using any flavor of UNIX
  • An excellent research record exemplified by strong publications
  • Strong communication skills in English, both spoken and written, are essential
The following qualifications are highly preferred, but not required. Candidates who possess any of these qualifications are encouraged to highlight them in the application:
  • Basic understanding of human disease biology and/or microbiology
  • Experience in analyzing metagenomic datasets from human gut microbiota
  • Experience in handling multi-omics data, including metabolomics and proteomics
  • Experience in distributed and cloud computing technologies
  • Familiarity with bioinformatics programming environments such as BioPython/BioPerl

Place of employment
The place of employment is at Novo Nordisk Foundation Center for Basic Metabolic Research, Maersk Tower, Panum Institute, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment.

Terms of employment
The three postdoc positions are full-time positions for 2 years. The starting date is August 1, 2019 or as soon as possible thereafter.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
The positions are covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013

Questions
For further information, please contact Associate Professor Manimozhiyan Arumugam at arumugam@sund.ku.dk . For questions regarding the recruitment procedure, please contact SUND HR CBMR at mlr@sund.ku.dk .

International applicants may find these links useful www.ism.ku.dk (International Staff Mobility) and https://www.workindenmark.dk/

Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore your application must include the following documents/attachments – all in PDF format:
  • A letter of motivation
  • Curriculum vitae
  • Publications list
  • At least two letters of references, maximum four
  • Documentation of research and optionally teaching qualifications

Application deadline: June 21 2019, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

The University of Copenhagen wishes to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.

KU - SUND - PANUM KBH NKøbenhavn N2019-05-10T00:00:002019-06-21T00:00:00
330028180Scientist with molecular biology experienceRobot Do you want to be part of the drug development process in Novo Nordisk? In CMC Bioanalysis you will characterize cell banks, optimize assays for drug substance (DS) and drug product (DP) development and be responsible for fast analytical results for phase 1 and phase 2 clinical studies. If you enjoy working in an open, dynamic and social atmosphere with a strong focus on science and a high level of GMP you may be our new scientist! About the department CMC Bioanalysis is part of the Novo Nordisk Research Development (R D) family. We develop bioanalyses and deliver analytical results incl. characterization of cell banks and analysis of in process samples, drug substance, and drug product samples for the entire NN project portfolio in clinical trials all over the world. The department operates under GMP regulation. The position In this 12-month temporary position, you will be part of a team of 5 scientists and 9 laboratory technicians working with cell bank characterization and process related impurities analysed by e.g. qPCR, DNA sequencing, Southern Blot and ELISA. You will be part of a team that - along-side well established methods - are also looking to implement new technologies such as Next Generation Sequencing (NGS) and experience with NGS is therefore an advantage. You will be responsible for the timely approval and release of analytical results in compliance with GMP, including planning of laboratory work and review of data as well as qualification and maintenance of equipment and instruments. In addition, you will be responsible for the performance and optimisation of analytical assays. You are expected to take an active part in the daily operation of our laboratories including optimisation of workflows, SOP authoring, and troubleshooting of assays, when needed. Furthermore, you will be participating in cross organisational project groups and collaborating with other departments both in Quality Control and in other R D research units. Qualifications You hold a university degree within natural sciences with proven skills within molecular biology, preferably but not necessarily, with a PhD degree. You have experience with working in a GMP environment and you advocate the necessity of documentation and traceability. You are familiar with continuous improvements, strive for simplicity and have an open mind-set regarding optimisation, automation and digitalisation. As a person you enjoy being part of a team but are still able to work independently. You strive to improve the way you work by use of science and an on-going constructive dialogue with your colleagues and you thrive in helping your colleagues shine. You can handle several tasks at the same time and are self-confident in reaching the goals ahead of you. You have good communication skills and a positive mind-set. Furthermore, a good sense of humour and a light-hearted view on life will make a good match with your new colleagues in CMC Bioanalysis. Contact For further information, please contact team leader Birgitte Koch Jørgensen 45 30 79 20 49. Deadline 4th of June 2019 Millions rely on us To work for Novo Nordisk you will need the skills, dedication and ambition to change lives for the better for millions of patients living with diabetes and other chronical diseases. In exchange, we offer the chance to be part of a truly global workplace, where passion and engagement are met with opportunities for professional and personal development.

Do you want to be part of the drug development process in Novo Nordisk? In CMC Bioanalysis you will characterize cell banks, optimize assays for drug substance (DS) and drug product (DP) development and be responsible for fast analytical results for phase 1 and phase 2 clinical studies.

If you enjoy working in an open, dynamic and social atmosphere with a strong focus on science and a high level of GMP; you may be our new scientist!

 

About the department

CMC Bioanalysis is part of the Novo Nordisk Research & Development (R&D) family. We develop bioanalyses and deliver analytical results incl. characterization of cell banks and analysis of in process samples, drug substance, and drug product samples for the entire NN project portfolio in clinical trials all over the world. The department operates under GMP regulation.

 

The position

In this 12-month temporary position, you will be part of a team of 5 scientists and 9 laboratory technicians working with cell bank characterization and process related impurities analysed by e.g. qPCR, DNA sequencing, Southern Blot and ELISA. You will be part of a team that - along-side well established methods - are also looking to implement new technologies such as Next Generation Sequencing (NGS) and experience with NGS is therefore an advantage.

You will be responsible for the timely approval and release of analytical results in compliance with GMP, including planning of laboratory work and review of data as well as qualification and maintenance of equipment and instruments. In addition, you will be responsible for the performance and optimisation of analytical assays.

You are expected to take an active part in the daily operation of our laboratories including optimisation of workflows, SOP authoring, and troubleshooting of assays, when needed. Furthermore, you will be participating in cross organisational project groups and collaborating with other departments both in Quality Control and in other R&D research units.

 

Qualifications

You hold a university degree within natural sciences with proven skills within molecular biology, preferably but not necessarily, with a PhD degree.

You have experience with working in a GMP environment and you advocate the necessity of documentation and traceability.

You are familiar with continuous improvements, strive for simplicity and have an open mind-set regarding optimisation, automation and digitalisation.

As a person you enjoy being part of a team but are still able to work independently. You strive to improve the way you work by use of science and an on-going constructive dialogue with your colleagues and you thrive in helping your colleagues shine. You can handle several tasks at the same time and are self-confident in reaching the goals ahead of you. You have good communication skills and a positive mind-set. Furthermore, a good sense of humour and a light-hearted view on life will make a good match with your new colleagues in CMC Bioanalysis.

 

Contact

For further information, please contact team leader Birgitte Koch Jørgensen +45 30 79 20 49.

 

Deadline

4th of June 2019

 

Millions rely on us
To work for Novo Nordisk you will need the skills, dedication and ambition to change lives for the better for millions of patients living with diabetes and other chronical diseases. In exchange, we offer the chance to be part of a truly global workplace, where passion and engagement are met with opportunities for professional and personal development.

Novo Nordisk A/SMåløv2019-05-21T00:00:002019-06-04T00:00:00
da-DK

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