PhD fellowship in RNA biology and co-transcriptional processing at Department of Cellular and Molecular Medicine (ICMM)

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We are offering a PhD fellowship to a talented and highly motivated student interested in investigating novel factors regulate transcription and co-transcriptional processing. The successful candidate will be employed in the Gregersen group at the Institute of Cellular and Molecular Medicine (ICMM) at the Faculty of Health and Medical Sciences, University of Copenhagen.

About the lab and institute
The Gregersen group was established in the Spring 2021. The group focuses on various aspects of co-transcriptional regulation primarily mediated by RNA-binding proteins. Recent papers include: Gregersen et al. 2019 Cell [PMID: 31104839] and Gregersen et al. 2020 Nature Protocols [PMID: 31915390].
We use a wide range of experimental approaches including cell biology, next-generation sequencing (RNA-seq, TTchem-seq, mNET-seq, ChIP-seq, CLIP etc.) as well as molecular biology techniques (western blots, immunoprecipitations, peptide pull-outs and proteomics) to decipher the molecular mechanisms of factors involved in co-transcriptional regulation and the composition of transcription complexes.

The Gregersen group represents cutting-edge interdisciplinary research and training and is located in modern laboratories in the Mærsk tower at the Panum Institute within the ICMM. We have access to state-of-the-art facilities for cell engineering, next-generation sequencing, flow cytometry, and mass spectrometry.

For more information about our research please see: https://icmm.ku.dk/english/research-groups/gregersen-group/

Project description
The project will be focused on understanding how novel factors interacting with RNA polymerase II influences transcription and co-transcriptional processing of the newly made RNA transcript. The project involves generation of human cell lines using CRISPR/Cas technologies combined with profiling of transcription using a combination of RNA-seq approaches. The aim of the project is to improve our understanding of regulation of transcription and use this knowledge to increase our understanding of the molecular processes underlying diseases. The role of the candidate will primarily be to perform experiments in the laboratory, analyse and interpret data, scientific publication, and undertake training, as well as attend scientific seminars and conferences.

Principal supervisor is Lea H. Gregersen, ICMM, leag@sund.ku.dk
Start: November 2021 or soon thereafter.
Duration: 3 years as a PhD student.

Job description
Your key tasks as a PhD student at SUND are:

  • Carry out an independent research project under supervision
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
  • Obtain experience with teaching or other types of dissemination related to your PhD project
  • Teach and disseminate your knowledge
  • Write a PhD thesis on the grounds of your project.

Key criteria for the assessment of applicants
The candidate is expected to have a strong interest in fundamental scientific discoveries. Previous experience with any of the following is highly desirable (but not mandatory):

  • Molecular biology (PCR, cloning)
  • Mammalian cell culture and genome editing (CRISPR/Cas)
  • Western blotting
  • Immunoprecipitation and protein complex purification
  • High-throughput RNA sequencing.
Other important criteria are:

  • The grade point average achieved
  • Professional qualifications relevant to the PhD project
  • Previous publications
  • Relevant work experience
  • Other professional activities
  • Curious mind-set with a strong interest in transcription
  • Excellent English skills written and spoken.
As a prerequisite for a PhD fellowship employment, your master’s degree must be equivalent to a Danish master’s degree. We encourage you to read more in the assessment database: https://ufm.dk/en/education/recognition-and-transparency/find-assessments/assessment-database. Please note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science.

Place of employment
The place of employment is at the Department of Cellular and Molecular Medicine (ICMM), University of Copenhagen. ICMM offers a creative and ambitious scientific environment, with many different nationalities represented. ICMM aims to produce research with high international impact focusing on the functional cell, its genetic components and molecular cellular mechanisms in a medical context. ICMM currently comprises five research programs, three high profile Research Centers as well as a number of international research groups. The scientists at ICMM are involved in high quality research based undergraduate and graduate teaching programs at the University of Copenhagen. More information can be found at www.icmm.ku.dk

Terms of employment
The employment as PhD fellow is full time and for 3 years.

It is conditioned upon the applicant’s success­ful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.

The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the University’s rules on achieving the degree. Salary, pension and terms of employment are in accordance with the agree­ment between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around 27,780 DKK/ approx. 3,730 Euro (April 2021-level), plus pension.

Questions
For specific information about the PhD fellowship, please contact the principal supervisor.

General information about PhD study at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/

Application procedure
Your application must be submitted electronically by clicking ‘Apply now’ below. Only applications submitted through the online system will be considered. The application must include the following documents in PDF format:

1. Motivated letter of application (max. one page)

2. CV incl. education, experience, language skills and other skills relevant for the position

3. Certified copy of original Master of Science diploma and transcript of records in the original language, including an authorized English translation if issued in other language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted.

4. Publication list (if possible)


Application deadline: 17 September 2021, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.

The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.



The Faculty of Health and Medical Sciences comprises approximately 7500 students, 1500 PhD students and 3200 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community. The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply

Skriv i din ansøgning, at du fandt jobbet på ofir.dk


PhD fellowship in RNA biology and co-transcriptional processing at Department of Cellular and Molecular Medicine (ICMM)

We are offering a PhD fellowship to a talented and highly motivated student interested in investigating novel factors regulate transcription and co-transcriptional processing. The successful candidate will be employed in the Gregersen group at the Institute of Cellular and Molecular Medicine (ICMM) at the Faculty of Health and Medical Sciences, University of Copenhagen.

About the lab and institute
The Gregersen group was established in the Spring 2021. The group focuses on various aspects of co-transcriptional regulation primarily mediated by RNA-binding proteins. Recent papers include: Gregersen et al. 2019 Cell [PMID: 31104839] and Gregersen et al. 2020 Nature Protocols [PMID: 31915390].
We use a wide range of experimental approaches including cell biology, next-generation sequencing (RNA-seq, TTchem-seq, mNET-seq, ChIP-seq, CLIP etc.) as well as molecular biology techniques (western blots, immunoprecipitations, peptide pull-outs and proteomics) to decipher the molecular mechanisms of factors involved in co-transcriptional regulation and the composition of transcription complexes.

The Gregersen group represents cutting-edge interdisciplinary research and training and is located in modern laboratories in the Mærsk tower at the Panum Institute within the ICMM. We have access to state-of-the-art facilities for cell engineering, next-generation sequencing, flow cytometry, and mass spectrometry.

For more information about our research please see: https://icmm.ku.dk/english/research-groups/gregersen-group/

Project description
The project will be focused on understanding how novel factors interacting with RNA polymerase II influences transcription and co-transcriptional processing of the newly made RNA transcript. The project involves generation of human cell lines using CRISPR/Cas technologies combined with profiling of transcription using a combination of RNA-seq approaches. The aim of the project is to improve our understanding of regulation of transcription and use this knowledge to increase our understanding of the molecular processes underlying diseases. The role of the candidate will primarily be to perform experiments in the laboratory, analyse and interpret data, scientific publication, and undertake training, as well as attend scientific seminars and conferences.

Principal supervisor is Lea H. Gregersen, ICMM, leag@sund.ku.dk
Start: November 2021 or soon thereafter.
Duration: 3 years as a PhD student.

Job description
Your key tasks as a PhD student at SUND are:

  • Carry out an independent research project under supervision
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
  • Obtain experience with teaching or other types of dissemination related to your PhD project
  • Teach and disseminate your knowledge
  • Write a PhD thesis on the grounds of your project.

Key criteria for the assessment of applicants
The candidate is expected to have a strong interest in fundamental scientific discoveries. Previous experience with any of the following is highly desirable (but not mandatory):

  • Molecular biology (PCR, cloning)
  • Mammalian cell culture and genome editing (CRISPR/Cas)
  • Western blotting
  • Immunoprecipitation and protein complex purification
  • High-throughput RNA sequencing.
Other important criteria are:

  • The grade point average achieved
  • Professional qualifications relevant to the PhD project
  • Previous publications
  • Relevant work experience
  • Other professional activities
  • Curious mind-set with a strong interest in transcription
  • Excellent English skills written and spoken.
As a prerequisite for a PhD fellowship employment, your master’s degree must be equivalent to a Danish master’s degree. We encourage you to read more in the assessment database: https://ufm.dk/en/education/recognition-and-transparency/find-assessments/assessment-database. Please note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science.

Place of employment
The place of employment is at the Department of Cellular and Molecular Medicine (ICMM), University of Copenhagen. ICMM offers a creative and ambitious scientific environment, with many different nationalities represented. ICMM aims to produce research with high international impact focusing on the functional cell, its genetic components and molecular cellular mechanisms in a medical context. ICMM currently comprises five research programs, three high profile Research Centers as well as a number of international research groups. The scientists at ICMM are involved in high quality research based undergraduate and graduate teaching programs at the University of Copenhagen. More information can be found at www.icmm.ku.dk

Terms of employment
The employment as PhD fellow is full time and for 3 years.

It is conditioned upon the applicant’s success­ful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.

The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the University’s rules on achieving the degree. Salary, pension and terms of employment are in accordance with the agree­ment between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around 27,780 DKK/ approx. 3,730 Euro (April 2021-level), plus pension.

Questions
For specific information about the PhD fellowship, please contact the principal supervisor.

General information about PhD study at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/

Application procedure
Your application must be submitted electronically by clicking ‘Apply now’ below. Only applications submitted through the online system will be considered. The application must include the following documents in PDF format:

1. Motivated letter of application (max. one page)

2. CV incl. education, experience, language skills and other skills relevant for the position

3. Certified copy of original Master of Science diploma and transcript of records in the original language, including an authorized English translation if issued in other language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted.

4. Publication list (if possible)


Application deadline: 17 September 2021, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.

The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.



The Faculty of Health and Medical Sciences comprises approximately 7500 students, 1500 PhD students and 3200 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community. The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply

Skriv i din ansøgning, at du fandt jobbet på ofir.dk


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