PhD fellowship in Wound Infection Peptidomics

PhD fellowship in Wound Infection Peptidomics
Department of Pharmacy
Faculty of Health and Medical Sciences (SUND)
University of Copenhagen

The Department of Pharmacy is offering a three-year PhD fellowship within the field of biomarker discovery in mass-spectrometry based wound infection peptidomics. The PhD project will be carried out within the newly established LEO Foundation Center for Cutaneous Drug Delivery (LFCCDD), which is funded over a 10-year period by the LEO Foundation and the University of Copenhagen. The center aims to be recognized as an international excellence center, performing state-of-the-art research and creating innovative solutions within cutaneous drug delivery of both small and large molecules.
The successful applicant will be a member of the Novel Biological Models group and will have the opportunity for cross-disciplinary research in collaboration with the other sections of the centre as well as external collaborators. The fellowship is available from the 1st of June 2018 or as soon as possible thereafter.

Project description
The disease burden of failing skin repair and non-healing ulcers is extensive and represents significant challenges in health care systems worldwide. Therefore, there is a great an unmet need for novel diagnostic approaches to better predict wound infection and healing.
A major contributor to wound healing impairment is uncontrolled and excessive protease activity, from both endogenous and bacterial origin. Proteolytic protein and/or peptide patterns could therefore demonstrate healing activity and bacterial infection.
Using a recently established peptidomics approach, the PhD project will focus on various endogenous and bacterial proteases, study their interactions and determine their substrates during wounding. The main goal of our research is the development of early diagnostics and novel therapeutic concepts to target non-healing infected wounds unresponsive to currently available wound care regimes.

The candidate will be a member of the Novel Biological Models group within the LEO Foundation Center for Cutaneous Drug Delivery and will work in close collaboration with Bispebjerg Hospital, Lund University and the DTU Proteomics Core Facility. Furthermore, she/he will have the opportunity for further cross-disciplinary collaborations with the other groups of the centre.

Supervisors
Assistant Professor Mariena J.A. van der Plas
E-mail: mariena.van_der_plas@sund.ku.dk, phone: + 45 35 33 27 16

Professor Hanne M. Nielsen
E-mail: hanne.morck@sund.ku.dk

Required qualifications
As an applicant you must have:

  • Obtained a relevant Master´s degree prior to the starting date
  • Fluency in English and excellent communication skills, both oral and written.
  • The ability to work in an interdisciplinary environment.
  • The ability to travel for performing experiments at our collaborators at DTU and Lund University, Sweden.
Preferred qualifications
The ideal candidate for this project has skills in peptidomics or proteomics, bacterial culture techniques, sample preparation and mass-spectrometry data interpretation. Furthermore, experience within host-pathogen interactions in skin or wound biology is an advantage.

Job description
Your key tasks as a PhD fellow at the Faculty are to:
  • Carry through an independent research project under supervision
  • Write scientific articles and the PhD thesis on the grounds of your research project
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
  • Obtain experience with teaching and other types of dissemination related to your PhD project
  • Participate in the undergraduate teaching of students in pharmaceutical sciences
  • Participate in national and international conferences and scientific meetings
  • Stay at an external research institution, preferably abroad
Key criteria for the assessment of applicants
Professional qualifications relevant to the PhD programme
  • Relevant work experience
  • Previous publications
  • The grade point average achieved
  • Other professional activities
  • Language skills
  • The successful applicant is also required to be enterprising and to possess good interpersonal skills
Formal requirements
The successful applicant will be requested to formally apply for enrolment as a PhD student at the Faculty of Health and Medical Sciences according to the rules stipulated in the Ministerial order on the PhD programme at the universities (PhD order) from the Ministry of Science, Innovation, and Higher Education and the guidelines for the PhD programme at the Faculty of Health and Medical Sciences. The PhD student is expected to be affiliated to the graduate programme in pharmaceutical sciences, Drug Research Academy.

Terms of employment
The position as a PhD fellow is available for a 3-year period. Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organizations. Minimum monthly salary is DKK 26.455 (taxable) + pension contribution. The position is covered by the Protocol on Job Structure.

Application procedure
The application, in English, must be submitted electronically by clicking APPLY NOW below.
Your application must include:
  • Cover letter (approx. 1 page) describing your background, qualifications, interest and motivation for applying for this position
  • Full CV
  • Diploma and transcripts of records: Master´s degree diploma (including grade transcripts for bachelor´s and master´s degrees). Applicants with a Master´s degree from abroad should also enclose a short description of the grading scale used.
  • Other information for consideration, e.g. list of publications and relevant certificates
  • Names and contact details of references and/or recommendation letters
The University of Copenhagen wishes to encourage everyone interested in this post to apply, regardless of personal background.

Deadline for application
30.04.2018, 23:59 GMT+1. Please note that only online applications will be accepted.
Applications received later than this date will not be considered.

Post application procedure
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee.
Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at http://employment.ku.dk

Questions
For further information, applicants may contact supervisor Mariena van der Plas at mariena.van_der_plas@sund.ku.dk, or Administrator Marianne W. Jørgensen, e-mail: marianne.joergensen@sund.ku.dk, phone: +45 3533 6449.
For more information on working and living in Denmark visit http://ism.ku.dk (International staff mobility) and https://www.workindenmark.dk


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