PhD inRho GTPase function in the nucleus in the Brakebusch lab at BRIC

Faculty of Health and Medical Sciences
University of Copenhagen, Denmark


We are looking for a highly motivated and dynamic researcher for a 3 year PhD position starting in October 2020 in the Brakebusch lab. The Brakebusch lab is located at the Biotech Research and Innovation Center (BRIC) (www.bric.ku.dk/Research/Brakebusch_Group/), which is a Center of Excellence in biomedical research with around 200 scientists.

Our research
The ubiquitously expressed Rho GTPases RhoA, Rac1 and Cdc42 are important regulators of the cytoskeleton, but also involved in signal transduction processes regulating proliferation, differentiation and survival. While the cytoplasmic role of Rho GTPases is well described, little is known about the function of Rho GTPases in the nucleus, although actin polymerisation has demonstrated in the nucleus and is suggested to be involved in different nuclear processes such as the regulation of gene expression or DNA repair. Using novel genetic tools we would like to investigate now the specific function of Rho GTPases in the nucleus.

Your job
Using novel genetic tools you will investigate how nuclear Rho GTPase regulate nuclear morphology, DNA repair, gene expression, and replication in cultured cells. Based on the results it is planned to generate a genetically modified mouse strain to study nuclear Rho GTPase function in development and disease in vivo.

Profile
We are looking for a highly motivated and enthusiastic researcher with the following competencies and experience:

Essential experience and skills:

  • A Master degree in biological/biomedical science
  • Enthusiasm for experimental research and an ambitious mindset
  • Proficient communication skills and ability to work in a team
  • Excellent English skills written and spoken
Desirable experience and skills:

  • Experience in cell culture and molecular biology
  • Experience in CRISPR genome editing
Place of employment
The place of employment is at BRIC, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Our research facilities include modern laboratories and core facilities and an exciting research environment with ambitious researchers from all over the world.

Terms of employment
The employment as PhD is a full time with a duration of 3 years. Starting date is 1 October 2020, or after agreement.

It is conditioned upon the applicant’s success­ful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.

The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty’s rules on achieving the degree. Salary, pension and terms of employment are in accordance with the agree­ment between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around 27,590 DKK /approx. 3,700 EUR (April 2020-level) plus pension.

Questions
For further information please contact Cord Brakebusch email: cord.brakebusch@bric.ku.dk.

General information about PhD study at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/

Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).

Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format:

  1. Motivated letter of application (max. one page).
  2. CV incl. education, work/research experience, language skills and other skills relevant for the position.
  3. A certified/signed copy of the Master of Science certificate.
  4. List of publications.
Application deadline: 24 July 2020, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.

The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

Interviews are expected to be held in week 33-35.

The Faculty of Health and Medical Sciences comprises approximately 7850 students, 1700 PhD students and 4800 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community. The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position.




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