Ph.d.-studerende til projekt på Neurobiologisk Forskningsenhed, Rigshospitalet

Vi søger en kandidat til gennemførelse af et 3-årigt ph.d.-projekt, som skal udføres på Neurobiologisk Forskningsenhed (NRU) på Rigshospitalet. Forventet start er 01-10-2019 eller evt. før.



Om Neurobiologisk Forskningsenhed

På NRU arbejder vi med hjerneforskning til gavn for patienterne. Vi udfører translationel, neurovidenskabelig forskning i hjernens neurotransmission med det formål at udvikle forebyggende, diagnostiske og behandlingsmæssige fremskridt. Opdagelser frembragt ved studier i celler og dyr bringes videre i vores studier af raske forsøgspersoner og af patienter med hjerne-sygdomme. Vi anvender molekylær, strukturel og funktionel billeddannelse samt cellemodeller, dyr, og humant hjernevæv til at afdække sygdomsmekanismer og risikomarkører samt til at undersøge lægemiddeleffekter og forudsige deres kliniske værdi. Vi identificerer biomarkører for og mekanismer bag psykiatriske og neurologiske sygdomme, og vi udvikler dermed strategier for forebyggelse, diagnostik og nye behandlingsmetoder af hjernesygdomme.

NRU har et bredt nationalt og internationalt samarbejde og er hovedsæde for det Innovationsfonden-støttede Center for Experimental Medicine Neuropharmacology (NeuroPharm) og for det Lundbeckfonden-finansierede projekt BrainDrugs.



Baggrund

Sygdomme i hjernen, herunder psykiatriske sygdomme, udgør den største belastning blandt alle sygdomme, for såvel det enkelte menneske som for vores samfund. Det er derfor af afgørende betydning at udvikle nye og bedre metoder til at behandle mennesker med hjernesygdom. Imidlertid er der meget væsentlige udfordringer forbundet med dette, særligt hvad angår udviklingen af nye lægemidler til psykiatriske sygdomme. Gennem mange år har man anvendt dyremodeller for

psykiatriske sygdomme, men det har vedholdende vist sig, at lægemidler med lovende effekter i dyremodeller ikke har tilsvarende egenskaber, når de anvendes hos mennesker.

Ved NRU udvikler og anvender vi nye billeddannende og statistiske metoder, hvormed man hos mennesker direkte kan undersøge både farmakologiske og ikke-farmakologiske effekter på hjernen. Anvendelse af sådanne metoder bidrager til at kortlægge sygdomsmekanismer og sygdomsklassifikation, til at stille diagnoser tidligere og til at forudsige effekt af behandling. I nærværende projekt vil vi undersøge effekterne af kendte lægemidler hos raske forsøgspersoner og muligvis også hos patienter med obsessiv-kompulsiv sygdom.



Om ph.d.-projektet

Formålet med dette studie er at øge forståelsen for, hvilken rolle signalstoffet serotonin (også kendt som 5-hydroxytryptamine, 5-HT) spiller for raske menneskers hjernefunktion og adfærd. Hos en gruppe af raske forsøgspersoner vil vi undersøge, hvordan adfærden ændres efter tre ugers indtagelse af et lægemiddel, der ofte anvendes til behandling af depression, nemlig escitalopram. Escitalopram øger serotonin-signaleringen i hjernen, og vi vil undersøge denne effekt i forhold til en gruppe raske, der får placebo (”kalktabletter”) i tre uger. Efter tre uger undersøger vi begge grupper med en funktionel hjerneskanning (fMRI), hvor de blandt andet skal løse nogle opgaver i skanneren, og en omfattende neuropsykologisk undersøgelse. Vi er særligt interesserede i at finde ud af, hvordan escitalopram påvirker kognitiv fleksibilitet, herunder evnen til hurtigt at ændre strategi og handlemønstre. Projektet ledes i samarbejde med prof. Barbara Sahakian og prof. Trevor Robbins, begge ved Cambridge Universitet, UK.



Om kandidaten

Vi søger en kandidat med psykologfaglig baggrund og gode samarbejdsevner. Tidligere involvering i klinisk eller biomedicinsk forskning vil være en fordel. Gode mundtlige og skriftlige dansk- og engelskkundskaber forudsættes.

Den succesfulde kandidat vil gennem dette ph.d.-studie opnå betydelig erfaring indenfor bl.a. projektstyring, tværfagligt samarbejde, rekruttering af forsøgspersoner, praktisk gennemførelse af MR-skanninger, neuropsykologisk tests og avancerede dataanalyse-metoder samt præsentation og publicering af videnskabelige resultater.



Løn og ansættelsesvilkår

Ansættelse pr. 01-10-2019. Løn er i henhold til gældende overenskomst. Dit arbejdssted vil være Neurobiologisk Forskningsenhed, Rigshospitalet Blegdamsvej.



Yderligere information

Yderligere information om forskningsenheden kan ses på https://nru.dk/. Hvis du har konkrete spørgsmål vedr. stillingen, kan du kontakte forskningsadministrator Birgit Tang (tlf.: 3545 6740), email: birgit.tang@nru.dk eller professor Gitte Moos Knudsen (tlf.: 3545 6720, email: gitte.knudsen@nru.dk).



Ansøgning og ansøgningsfrist

Send din ansøgning elektronisk senest mandag den 12-08-2019, kl. 12:00. Ansøgningnen skal indeholde et følgebrev, et CV og eksamenspapirer (karakterudskrift/bevis) og kan derudover også indeholde en liste med publikationer samt relevante anbefalinger.

Søg stillingen ved at klikke på ”Søg job”-knappen.












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330047137Phoenix-f07f2d2a12019-06-20T00:00:00Ph.d.-studerende til projekt på Neurobiologisk Forskningsenhed, Rigshospitalet Vi søger en kandidat til gennemførelse af et 3-årigt ph.d.-projekt, som skal udføres på Neurobiologisk Forskningsenhed (NRU) på Rigshospitalet. Forventet start er 01-10-2019 eller evt. før.



Om Neurobiologisk Forskningsenhed

På NRU arbejder vi med hjerneforskning til gavn for patienterne. Vi udfører translationel, neurovidenskabelig forskning i hjernens neurotransmission med det formål at udvikle forebyggende, diagnostiske og behandlingsmæssige fremskridt. Opdagelser frembragt ved studier i celler og dyr bringes videre i vores studier af raske forsøgspersoner og af patienter med hjerne-sygdomme. Vi anvender molekylær, strukturel og funktionel billeddannelse samt cellemodeller, dyr, og humant hjernevæv til at afdække sygdomsmekanismer og risikomarkører samt til at undersøge lægemiddeleffekter og forudsige deres kliniske værdi. Vi identificerer biomarkører for og mekanismer bag psykiatriske og neurologiske sygdomme, og vi udvikler dermed strategier for forebyggelse, diagnostik og nye behandlingsmetoder af hjernesygdomme.

NRU har et bredt nationalt og internationalt samarbejde og er hovedsæde for det Innovationsfonden-støttede Center for Experimental Medicine Neuropharmacology (NeuroPharm) og for det Lundbeckfonden-finansierede projekt BrainDrugs.



Baggrund

Sygdomme i hjernen, herunder psykiatriske sygdomme, udgør den største belastning blandt alle sygdomme, for såvel det enkelte menneske som for vores samfund. Det er derfor af afgørende betydning at udvikle nye og bedre metoder til at behandle mennesker med hjernesygdom. Imidlertid er der meget væsentlige udfordringer forbundet med dette, særligt hvad angår udviklingen af nye lægemidler til psykiatriske sygdomme. Gennem mange år har man anvendt dyremodeller for

psykiatriske sygdomme, men det har vedholdende vist sig, at lægemidler med lovende effekter i dyremodeller ikke har tilsvarende egenskaber, når de anvendes hos mennesker.

Ved NRU udvikler og anvender vi nye billeddannende og statistiske metoder, hvormed man hos mennesker direkte kan undersøge både farmakologiske og ikke-farmakologiske effekter på hjernen. Anvendelse af sådanne metoder bidrager til at kortlægge sygdomsmekanismer og sygdomsklassifikation, til at stille diagnoser tidligere og til at forudsige effekt af behandling. I nærværende projekt vil vi undersøge effekterne af kendte lægemidler hos raske forsøgspersoner og muligvis også hos patienter med obsessiv-kompulsiv sygdom.



Om ph.d.-projektet

Formålet med dette studie er at øge forståelsen for, hvilken rolle signalstoffet serotonin (også kendt som 5-hydroxytryptamine, 5-HT) spiller for raske menneskers hjernefunktion og adfærd. Hos en gruppe af raske forsøgspersoner vil vi undersøge, hvordan adfærden ændres efter tre ugers indtagelse af et lægemiddel, der ofte anvendes til behandling af depression, nemlig escitalopram. Escitalopram øger serotonin-signaleringen i hjernen, og vi vil undersøge denne effekt i forhold til en gruppe raske, der får placebo (”kalktabletter”) i tre uger. Efter tre uger undersøger vi begge grupper med en funktionel hjerneskanning (fMRI), hvor de blandt andet skal løse nogle opgaver i skanneren, og en omfattende neuropsykologisk undersøgelse. Vi er særligt interesserede i at finde ud af, hvordan escitalopram påvirker kognitiv fleksibilitet, herunder evnen til hurtigt at ændre strategi og handlemønstre. Projektet ledes i samarbejde med prof. Barbara Sahakian og prof. Trevor Robbins, begge ved Cambridge Universitet, UK.



Om kandidaten

Vi søger en kandidat med psykologfaglig baggrund og gode samarbejdsevner. Tidligere involvering i klinisk eller biomedicinsk forskning vil være en fordel. Gode mundtlige og skriftlige dansk- og engelskkundskaber forudsættes.

Den succesfulde kandidat vil gennem dette ph.d.-studie opnå betydelig erfaring indenfor bl.a. projektstyring, tværfagligt samarbejde, rekruttering af forsøgspersoner, praktisk gennemførelse af MR-skanninger, neuropsykologisk tests og avancerede dataanalyse-metoder samt præsentation og publicering af videnskabelige resultater.



Løn og ansættelsesvilkår

Ansættelse pr. 01-10-2019. Løn er i henhold til gældende overenskomst. Dit arbejdssted vil være Neurobiologisk Forskningsenhed, Rigshospitalet Blegdamsvej.



Yderligere information

Yderligere information om forskningsenheden kan ses på https://nru.dk/. Hvis du har konkrete spørgsmål vedr. stillingen, kan du kontakte forskningsadministrator Birgit Tang (tlf.: 3545 6740), email: birgit.tang@nru.dk eller professor Gitte Moos Knudsen (tlf.: 3545 6720, email: gitte.knudsen@nru.dk).



Ansøgning og ansøgningsfrist

Send din ansøgning elektronisk senest mandag den 12-08-2019, kl. 12:00. Ansøgningnen skal indeholde et følgebrev, et CV og eksamenspapirer (karakterudskrift/bevis) og kan derudover også indeholde en liste med publikationer samt relevante anbefalinger.

Søg stillingen ved at klikke på ”Søg job”-knappen.











Vi søger en kandidat til gennemførelse af et 3-årigt ph.d.-projekt, som skal udføres på Neurobiologisk Forskningsenhed (NRU) på Rigshospitalet. Forventet start er 01-10-2019 eller evt. før. Om Neurobiologisk Forskningsenhed På NRU arbejder vi med hjerneforskning til gavn for patienterne. Vi udfører translationel, neurovidenskabelig forskning i hjernens neurotransmission med det formål at udvikle forebyggende, diagnostiske og behandlingsmæssige fremskridt. Opdagelser frembragt ved studier i celler og dyr bringes videre i vores studier af raske forsøgspersoner og af patienter med hjerne-sygdomme. Vi anvender molekylær, strukturel og funktionel billeddannelse samt cellemodeller, dyr, og humant hjernevæv til at afdække sygdomsmekanismer og risikomarkører samt til at undersøge lægemiddeleffekter og forudsige deres kliniske værdi. Vi identificerer biomarkører for og mekanismer bag psykiatriske og neurologiske sygdomme, og vi udvikler dermed strategier for forebyggelse, diagnostik og nye behandlingsmetoder af hjernesygdomme. NRU har et bredt nationalt og internationalt samarbejde og er hovedsæde for det Innovationsfonden-støttede Center for Experimental Medicine Neuropharmacology (NeuroPharm) og for det Lundbeckfonden-finansierede projekt BrainDrugs. Baggrund Sygdomme i hjernen, herunder psykiatriske sygdomme, udgør den største belastning blandt alle sygdomme, for såvel det enkelte menneske som for vores samfund. Det er derfor af afgørende betydning at udvikle nye og bedre metoder til at behandle mennesker med hjernesygdom. Imidlertid er der meget væsentlige udfordringer forbundet med dette, særligt hvad angår udviklingen af nye lægemidler til psykiatriske sygdomme. Gennem mange år har man anvendt dyremodeller for psykiatriske sygdomme, men det har vedholdende vist sig, at lægemidler med lovende effekter i dyremodeller ikke har tilsvarende egenskaber, når de anvendes hos mennesker. Ved NRU udvikler og anvender vi nye billeddannende og statistiske metoder, hvormed man hos mennesker direkte kan undersøge både farmakologiske og ikke-farmakologiske effekter på hjernen. Anvendelse af sådanne metoder bidrager til at kortlægge sygdomsmekanismer og sygdomsklassifikation, til at stille diagnoser tidligere og til at forudsige effekt af behandling. I nærværende projekt vil vi undersøge effekterne af kendte lægemidler hos raske forsøgspersoner og muligvis også hos patienter med obsessiv-kompulsiv sygdom. Om ph.d.-projektet Formålet med dette studie er at øge forståelsen for, hvilken rolle signalstoffet serotonin (også kendt som 5-hydroxytryptamine, 5-HT) spiller for raske menneskers hjernefunktion og adfærd. Hos en gruppe af raske forsøgspersoner vil vi undersøge, hvordan adfærden ændres efter tre ugers indtagelse af et lægemiddel, der ofte anvendes til behandling af depression, nemlig escitalopram. Escitalopram øger serotonin-signaleringen i hjernen, og vi vil undersøge denne effekt i forhold til en gruppe raske, der får placebo ( kalktabletter ) i tre uger. Efter tre uger undersøger vi begge grupper med en funktionel hjerneskanning (fMRI), hvor de blandt andet skal løse nogle opgaver i skanneren, og en omfattende neuropsykologisk undersøgelse. Vi er særligt interesserede i at finde ud af, hvordan escitalopram påvirker kognitiv fleksibilitet, herunder evnen til hurtigt at ændre strategi og handlemønstre. Projektet ledes i samarbejde med prof. Barbara Sahakian og prof. Trevor Robbins, begge ved Cambridge Universitet, UK. Om kandidaten Vi søger en kandidat med psykologfaglig baggrund og gode samarbejdsevner. Tidligere involvering i klinisk eller biomedicinsk forskning vil være en fordel. Gode mundtlige og skriftlige dansk- og engelskkundskaber forudsættes. Den succesfulde kandidat vil gennem dette ph.d.-studie opnå betydelig erfaring indenfor bl.a. projektstyring, tværfagligt samarbejde, rekruttering af forsøgspersoner, praktisk gennemførelse af MR-skanninger, neuropsykologisk tests og avancerede dataanalyse-metoder samt præsentation og publicering af videnskabelige resultater. Løn og ansættelsesvilkår Ansættelse pr. 01-10-2019. Løn er i henhold til gældende overenskomst. Dit arbejdssted vil være Neurobiologisk Forskningsenhed, Rigshospitalet Blegdamsvej. Yderligere information Yderligere information om forskningsenheden kan ses på https: nru.dk . Hvis du har konkrete spørgsmål vedr. stillingen, kan du kontakte forskningsadministrator Birgit Tang (tlf.: 3545 6740), email: birgit.tang@nru.dk eller professor Gitte Moos Knudsen (tlf.: 3545 6720, email: gitte.knudsen@nru.dk). Ansøgning og ansøgningsfrist Send din ansøgning elektronisk senest mandag den 12-08-2019, kl. 12:00. Ansøgningnen skal indeholde et følgebrev, et CV og eksamenspapirer (karakterudskrift bevis) og kan derudover også indeholde en liste med publikationer samt relevante anbefalinger. Søg stillingen ved at klikke på Søg job -knappen.11jobnetf07f2d2a100000000000aDK_OFIR_02DKDanmark228DKK2019-08-12T00:00:000000https://candidate.hr-manager.net/ApplicationInit.aspx?cid=342&ProjectId=218976&DepartmentId=17200&MediaId=4710&SkipAdvertisement=true0EuropaDanmarkSjælland & øerStorkøbenhavnKøbenhavn3550582Rigshospitalet11Blegdamsvej 92100København ØDKDanmark0DKDanmarkDKDanmark8Fuldtid47Tidsbegrænset781658JobNet5007795500779510020-06-20190https://dispatcher.ofir.dk/statistic/register?context=FeedEntrySearchedCount&feedId=dc2beb84&entryId=f07f2d2ahttps://dispatcher.ofir.dk/statistic/register?context=FeedEntryDisplayCount&feedId=dc2beb84&entryId=f07f2d2ahttps://dispatcher.ofir.dk/statistic/register?context=JobApplicationInitiatedCount&feedId=dc2beb84&entryId=f07f2d2a&page=ShowJob&component=SendApplicationButtonhttps://dispatcher.ofir.dk/statistic/register?context=JobApplicationAppliedCount&feedId=dc2beb84&entryId=f07f2d2a&page=EmailApplyForm&component=SendApplicationButton1Dansk3Læse/ tale221101Biolog20Ingeniør og naturvidenskab362113174noreply@ofir.comDKDanmarkDKDanmark330048932PhD fellow in Computational structural biology, Department of BiologyRobot One or two PhD positions are available from September 1, 2019, or as soon as possible thereafter, in the Lindorff-Larsen group, Department of Biology, Faculty of Science, University of Copenhagen, Denmark. The PhD students will work on a project called BRAINSTRUC within the area of computational aspects of integrative structural biology. BRAINSTRUC is a collaboration between six research groups within structural biology spanning a range of techniques and biological topics, and the successful candidate(s) will be part of a strong and interdisciplinary group of scientists working on developing and applying methods to study the structure and dynamics of proteins. About BRAINSTRUC and the research environment The successful candidates will work on computational approaches in integrative structural biology and will be supervised by Professor Kresten Lindorff-Larsen. The project is part of a large interdisciplinary effort called BRAINSTRUC (www.brainstruc.ku.dk) funded by the Lundbeck Foundation. In addition to the Lindorff-Larsen group, the project also involves groups devoted to experimental biophysics and structural biology including X-ray crystallography, CryoEM, NMR, SAXS and SANS. The biological focus within BRAINSTRUC is on protein molecules and complexes in the human brain including membrane transporters, the immune system and protein aggregation. The PhD student will use molecular simulations and modelling to study these systems in collaboration with the experimental groups within BRAINSTRUC (for more details including the other partners see www.brainstruc.ku.dk). We offer a highly dynamic and international research environment located at the Biocenter in central Copenhagen, Denmark (www.bio.ku.dk). The Lindorff-Larsen group combines computational and experimental methods to study the structure, function and dynamics of biomacromolecules. Research within the group covers a broad range of areas in protein science including understanding the relationship between protein dynamics and function, protein design, protein folding and stability, drug resistance, and determining the structures of proteins by integrating experiments and simulations. The group is part of the Linderstrøm-Lang Centre for Protein Science at the Department of Biology. The research at the centre is highly interdisciplinary ranging from molecular cell biology to protein chemistry, advanced biophysics and computational biology. The centre also has access to state of the art experimental and computational facilities. Project description The PhD students will work on one or more of the subprojects within BRAINSTRUC, focusing on computational methods, both existing and newly developed, together with experimental data to determine the structure and dynamics of complex biomolecules and their assemblies. Experimental data include from SAXS, SANS, Cryo-EM, NMR, X-ray diffraction, and other sources of structural information. For an introduction to the research topic see e.g. our recent review (Bottaro et al, Science, 2018, http: dx.doi.org 10.1126 science.aat4010). Research topics for the PhD projects include: Using coarse-grained and all-atom simulations to study large molecular complexes Using molecular simulations to interpret cryoEM experiments Integrative methods to study intrinsically disordered proteins Principal supervisor is Professor Kresten Lindorff-Larsen, Linderstrøm-Lang Centre for Protein Science and Structural Biology and NMR Laboratory Department of Biology, lindorff@bio.ku.dk. Job description The position is available for a 3-year period and your key tasks as a PhD student at SCIENCE are: To manage and carry through your research project Attend PhD courses Write scientific articles and your PhD thesis Teach and disseminate your research To stay at an external research institution for a few months Work for the department Qualifications We are seeking motivated and strong applicants with a MSc degree in biophysics, physics, chemistry or biochemistry or similar fields. The ideal candidate has with documented research experience within the area of biomolecular simulation. Experience with methods that integrate experimental data and computation will be a strong plus, as will simulations of large molecular assemblies. Experience with working with membrane proteins is also a plus. Candidates must have good interpersonal and communication skills. Fluency in spoken and written English is a requirement. Terms of employment The position is covered by the Memorandum on Job Structure for Academic Staff. Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. The starting salary is currently at a minimum DKK 325.625 (approx. €43,400) including annual supplement ( pension up to DKK 44,980). Negotiation for salary supplement is possible. Application Procedure The application, in English, must be submitted electronically by clicking APPLY NOW below. Please include A cover letter (max 1. page) explaining your background, key skills and how they are relevant to the research in BRAINSTRUC, and your motivation for applying Curriculum vitae (max 2. pages) including educational background previous research experience List of publications (including preprints and papers in review) Diploma and transcripts of records (BSc and MSc) Contact details for two former employers or supervisors (no reference letters should be attached) The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background. The deadline for applications is 19th July 2019 23:59 GMT 2. After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. Afterwards an assessment committee will be appointed to evaluate the selected applications. The applicants will be notified of the composition of the committee and the final selection of a successful candidate will be made by the Head of Department, based on the recommendations of the assessment committee and the interview committee. The main criterion for selection will be the research potential of the applicant and the above mentioned skills. The successful candidate will then be requested to formally apply for enrolment as a PhD student at the PhD school of Science. You can read more about the recruitment process at http: employment.ku.dk faculty recruitment-process . Questions For specific information about the PhD scholarship, please contact the principal supervisor Professor Kresten Lindorff-Larsen, Linderstrøm-Lang Centre for Protein Science and Structural Biology and NMR Laboratory Department of Biology, lindorff@bio.ku.dk. General information about PhD programmes at SCIENCE is available at http: www.science.ku.dk phd.

One or two PhD positions are available from September 1, 2019, or as soon as possible thereafter, in the Lindorff-Larsen group, Department of Biology, Faculty of Science, University of Copenhagen, Denmark. The PhD students will work on a project called BRAINSTRUC within the area of computational aspects of integrative structural biology. BRAINSTRUC is a collaboration between six research groups within structural biology spanning a range of techniques and biological topics, and the successful candidate(s) will be part of a strong and interdisciplinary group of scientists working on developing and applying methods to study the structure and dynamics of proteins.



About BRAINSTRUC and the research environment

The successful candidates will work on computational approaches in integrative structural biology and will be supervised by Professor Kresten Lindorff-Larsen. The project is part of a large interdisciplinary effort called BRAINSTRUC (www.brainstruc.ku.dk) funded by the Lundbeck Foundation. In addition to the Lindorff-Larsen group, the project also involves groups devoted to experimental biophysics and structural biology including X-ray crystallography, CryoEM, NMR, SAXS and SANS. The biological focus within BRAINSTRUC is on protein molecules and complexes in the human brain including membrane transporters, the immune system and protein aggregation. The PhD student will use molecular simulations and modelling to study these systems in collaboration with the experimental groups within BRAINSTRUC (for more details including the other partners see www.brainstruc.ku.dk).



We offer a highly dynamic and international research environment located at the Biocenter in central Copenhagen, Denmark (www.bio.ku.dk). The Lindorff-Larsen group combines computational and experimental methods to study the structure, function and dynamics of biomacromolecules. Research within the group covers a broad range of areas in protein science including understanding the relationship between protein dynamics and function, protein design, protein folding and stability, drug resistance, and determining the structures of proteins by integrating experiments and simulations.



The group is part of the Linderstrøm-Lang Centre for Protein Science at the Department of Biology. The research at the centre is highly interdisciplinary ranging from molecular cell biology to protein chemistry, advanced biophysics and computational biology. The centre also has access to state of the art experimental and computational facilities.



Project description

The PhD students will work on one or more of the subprojects within BRAINSTRUC, focusing on computational methods, both existing and newly developed, together with experimental data to determine the structure and dynamics of complex biomolecules and their assemblies. Experimental data include from SAXS, SANS, Cryo-EM, NMR, X-ray diffraction, and other sources of structural information. For an introduction to the research topic see e.g. our recent review (Bottaro et al, Science, 2018, http://dx.doi.org/10.1126/science.aat4010).



Research topics for the PhD projects include:



  • Using coarse-grained and all-atom simulations to study large molecular complexes
  • Using molecular simulations to interpret cryoEM experiments
  • Integrative methods to study intrinsically disordered proteins


Principal supervisor is Professor Kresten Lindorff-Larsen, Linderstrøm-Lang Centre for Protein Science and Structural Biology and NMR Laboratory Department of Biology, lindorff@bio.ku.dk.



Job description

The position is available for a 3-year period and your key tasks as a PhD student at SCIENCE are:



  • To manage and carry through your research project
  • Attend PhD courses
  • Write scientific articles and your PhD thesis
  • Teach and disseminate your research
  • To stay at an external research institution for a few months
  • Work for the department


Qualifications

We are seeking motivated and strong applicants with a MSc degree in biophysics, physics, chemistry or biochemistry or similar fields. The ideal candidate has with documented research experience within the area of biomolecular simulation. Experience with methods that integrate experimental data and computation will be a strong plus, as will simulations of large molecular assemblies. Experience with working with membrane proteins is also a plus.



Candidates must have good interpersonal and communication skills. Fluency in spoken and written English is a requirement.



Terms of employment

The position is covered by the Memorandum on Job Structure for Academic Staff.



Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.



The starting salary is currently at a minimum DKK 325.625 (approx. €43,400) including annual supplement (+ pension up to DKK 44,980). Negotiation for salary supplement is possible.



Application Procedure

The application, in English, must be submitted electronically by clicking APPLY NOW below.



Please include

  • A cover letter (max 1. page) explaining your background, key skills and how they are relevant to the research in BRAINSTRUC, and your motivation for applying
  • Curriculum vitae (max 2. pages) including educational background previous research experience
  • List of publications (including preprints and papers in review)
  • Diploma and transcripts of records (BSc and MSc)
  • Contact details for two former employers or supervisors (no reference letters should be attached)




The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.



The deadline for applications is 19th July 2019 23:59 GMT +2.



After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. Afterwards an assessment committee will be appointed to evaluate the selected applications. The applicants will be notified of the composition of the committee and the final selection of a successful candidate will be made by the Head of Department, based on the recommendations of the assessment committee and the interview committee.

The main criterion for selection will be the research potential of the applicant and the above mentioned skills. The successful candidate will then be requested to formally apply for enrolment as a PhD student at the PhD school of Science. You can read more about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/.



Questions

For specific information about the PhD scholarship, please contact the principal supervisor Professor Kresten Lindorff-Larsen, Linderstrøm-Lang Centre for Protein Science and Structural Biology and NMR Laboratory Department of Biology, lindorff@bio.ku.dk.



General information about PhD programmes at SCIENCE is available at http://www.science.ku.dk/phd.



KU - SCIENCE BIO - BRICKøbenhavn N2019-06-25T00:00:002019-07-19T00:00:00
330047149Postdoc in Computational structural biologyRobot One or two postdoctoral positions are available from Sept 1, 2019, or as soon as possible thereafter, in the Lindorff-Larsen group, Department of Biology, Faculty of Science, University of Copenhagen, Denmark. The postdoctoral fellows will work on a project called BRAINSTRUC within the area of computational aspects of integrative structural biology. BRAINSTRUC is a collaboration between six research groups within structural biology spanning a range of techniques and biological topics, and the successful candidate(s) will be part of a strong and interdisciplinary group of scientists working on developing and applying methods to study the structure and dynamics of proteins. About BRAINSTRUC and the research environment The successful candidates will work on computational approaches in integrative structural biology. The project is part of a large interdisciplinary effort called BRAINSTRUC (www.brainstruc.ku.dk) funded by the Lundbeck Foundation. In addition to the Lindorff-Larsen group, the project also involves groups devoted to experimental biophysics and structural biology including X-ray crystallography, CryoEM, NMR, SAXS and SANS. The biological focus within BRAINSTRUC is on protein molecules and complexes in the human brain including membrane transporters, the immune system and protein aggregation. The postdoctoral fellow will use molecular simulations and modelling to study these systems in collaboration with the experimental groups within BRAINSTRUC (for more details including the other partners see www.brainstruc.ku.dk). We offer a highly dynamic and international research environment located at the Biocenter in central Copenhagen, Denmark (www.bio.ku.dk). The Lindorff-Larsen group combines computational and experimental methods to study the structure, function and dynamics of biomacromolecules. Research within the group covers a broad range of areas in protein science including understanding the relationship between protein dynamics and function, protein design, protein folding and stability, drug resistance, and determining the structures of proteins by integrating experiments and simulations. We also use and develop biophysical methods to interpret genomic sequence variation. The group is part of the Linderstrøm-Lang Centre for Protein Science at the Department of Biology. The research at the centre is highly interdisciplinary ranging from molecular cell biology to protein chemistry, advanced biophysics and computational biology. The centre also has access to state of the art experimental and computational facilities. Details of the positions and research topics The postdoctoral fellows will work on one or more of the subprojects within BRAINSTRUC, focusing on computational methods, both existing and newly developed, together with experimental data to determine the structure and dynamics of complex biomolecules and their assemblies. Experimental data may include NMR, X-ray diffraction, SAXS, SANS, EPR, Cryo-EM and other sources of structural information. For an introduction to the research topic see e.g. our recent review (Bottaro et al, Science, 2018, http: dx.doi.org 10.1126 science.aat4010). The positions are for a period of 2 years. Research topics for the fellowships include: Developing our Bayesian Maximum Entropy approaches to integrate experiments and simulations Using coarse-grained and all-atom simulations to study large molecular complexes Using molecular simulations to interpret cryoEM data and experiments Integrative methods to study intrinsically disordered proteins Qualifications We are seeking motivated and strong applicants with a PhD degree in biophysics, physics, chemistry or biochemistry or similar fields with documented (via peer publications and preprints) prior research experience within one or more of these areas: All-atom of coarse-grained molecular dynamics simulations of proteins Interpreting structural data using molecular dynamics simulations Developing and applying methods for enhanced sampling simulations of biomolecules It will also be advantageous to have experience with one or more of the following topics: Familiarity with interpreting cryoEM data Using or developing methods for restraining of reweighting molecular simulations by experimental data For further information about the positions, please contact Professor Kresten Lindorff-Larsen (lindorff@bio.ku.dk). Further information about the Department may be found at https: www1.bio.ku.dk english The position is open from 1st September 2019 or as soon as possible thereafter. The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background. Terms of employment The position is covered by the Memorandum on Job Structure for Academic Staff. Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. The starting salary is currently up to DKK 430.569 including annual supplement ( pension up to DKK 73.627). Negotiation for salary supplement is possible. The application, in English, must be submitted electronically by clicking APPLY NOW below. Please include A cover letter (max 1. page) explaining your background, key skills and how they are relevant to the research in BRAINSTRUC, and your motivation for applying Curriculum vitae (max 2. pages) including educational background previous research experience List of publications (including preprints and papers in review) PhD diploma including any written evaluation if applicable. If you are expecting to defend your PhD before September 1st and would like to apply, please submit a letter from your supervisor regarding your expected defence date Contact details for two former employers or supervisors (no reference letters should be attached) The deadline for applications is 19th July 2019 23:59 GMT 2. After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. You can read about the recruitment process at http: employment.ku.dk faculty recruitment-process . Interviews will be held in August 2019.One or two postdoctoral positions are available from Sept 1, 2019, or as soon as possible thereafter, in the Lindorff-Larsen group, Department of Biology, Faculty of Science, University of Copenhagen, Denmark. The postdoctoral fellows will work on a project called BRAINSTRUC within the area of computational aspects of integrative structural biology. BRAINSTRUC is a collaboration between six research groups within structural biology spanning a range of techniques and biological topics, and the successful candidate(s) will be part of a strong and interdisciplinary group of scientists working on developing and applying methods to study the structure and dynamics of proteins.

About BRAINSTRUC and the research environment

The successful candidates will work on computational approaches in integrative structural biology. The project is part of a large interdisciplinary effort called BRAINSTRUC (www.brainstruc.ku.dk) funded by the Lundbeck Foundation. In addition to the Lindorff-Larsen group, the project also involves groups devoted to experimental biophysics and structural biology including X-ray crystallography, CryoEM, NMR, SAXS and SANS. The biological focus within BRAINSTRUC is on protein molecules and complexes in the human brain including membrane transporters, the immune system and protein aggregation. The postdoctoral fellow will use molecular simulations and modelling to study these systems in collaboration with the experimental groups within BRAINSTRUC (for more details including the other partners see www.brainstruc.ku.dk).

We offer a highly dynamic and international research environment located at the Biocenter in central Copenhagen, Denmark (www.bio.ku.dk). The Lindorff-Larsen group combines computational and experimental methods to study the structure, function and dynamics of biomacromolecules. Research within the group covers a broad range of areas in protein science including understanding the relationship between protein dynamics and function, protein design, protein folding and stability, drug resistance, and determining the structures of proteins by integrating experiments and simulations. We also use and develop biophysical methods to interpret genomic sequence variation.

The group is part of the Linderstrøm-Lang Centre for Protein Science at the Department of Biology. The research at the centre is highly interdisciplinary ranging from molecular cell biology to protein chemistry, advanced biophysics and computational biology. The centre also has access to state of the art experimental and computational facilities.

Details of the positions and research topics

The postdoctoral fellows will work on one or more of the subprojects within BRAINSTRUC, focusing on computational methods, both existing and newly developed, together with experimental data to determine the structure and dynamics of complex biomolecules and their assemblies. Experimental data may include NMR, X-ray diffraction, SAXS, SANS, EPR, Cryo-EM and other sources of structural information. For an introduction to the research topic see e.g. our recent review (Bottaro et al, Science, 2018, http://dx.doi.org/10.1126/science.aat4010). The positions are for a period of 2 years.

Research topics for the fellowships include:

  • Developing our Bayesian/Maximum Entropy approaches to integrate experiments and simulations
  • Using coarse-grained and all-atom simulations to study large molecular complexes
  • Using molecular simulations to interpret cryoEM data and experiments
  • Integrative methods to study intrinsically disordered proteins
Qualifications

We are seeking motivated and strong applicants with a PhD degree in biophysics, physics, chemistry or biochemistry or similar fields with documented (via peer publications and preprints) prior research experience within one or more of these areas:

  • All-atom of coarse-grained molecular dynamics simulations of proteins
  • Interpreting structural data using molecular dynamics simulations
  • Developing and applying methods for enhanced sampling simulations of biomolecules
It will also be advantageous to have experience with one or more of the following topics:

  • Familiarity with interpreting cryoEM data
  • Using or developing methods for restraining of reweighting molecular simulations by experimental data
For further information about the positions, please contact Professor Kresten Lindorff-Larsen (lindorff@bio.ku.dk). Further information about the Department may be found at https://www1.bio.ku.dk/english/

The position is open from 1st September 2019 or as soon as possible thereafter.

The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

Terms of employment

The position is covered by the Memorandum on Job Structure for Academic Staff.

Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.

The starting salary is currently up to DKK 430.569 including annual supplement (+ pension up to DKK 73.627). Negotiation for salary supplement is possible.

The application, in English, must be submitted electronically by clicking APPLY NOW below.

Please include

  • A cover letter (max 1. page) explaining your background, key skills and how they are relevant to the research in BRAINSTRUC, and your motivation for applying
  • Curriculum vitae (max 2. pages) including educational background previous research experience
  • List of publications (including preprints and papers in review)
  • PhD diploma including any written evaluation if applicable. If you are expecting to defend your PhD before September 1st and would like to apply, please submit a letter from your supervisor regarding your expected defence date
  • Contact details for two former employers or supervisors (no reference letters should be attached)
The deadline for applications is 19th July 2019 23:59 GMT +2.

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/.

Interviews will be held in August 2019.

KU - SCIENCE - NBIKøbenhavn Ø2019-06-20T00:00:002019-07-19T00:00:00
330054974Research Assistant for Structural Molecular Biology GroupRobot Presentation of the Center Novo Nordisk Foundation Center for Protein Research (www.cpr.ku.dk) at the Faculty of Health and Medical Sciences, University of Copenhagen, performs basic and applied discovery research on human proteins of biomedical relevance. The Center comprises a wide range of expertise and resources, from in silico target identification, mass spectrometry based proteomics, structural biology, protein production and characterization to elucidation of various disease mechanisms. One of the research areas in Montoya group is genome editing. We are using integrative structural biology approaches to understand how genome editing tools such as CRISPR-Cas12a work. We are especially interested in explore how CRISPR-Cas12a is able to recognize and cut a specific DNA-target (1, 2). Stella, S., et al., Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity. Cell, 2018. Stella, S., P. Alcon, and G. Montoya, Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage. Nature, 2017. Job description The project aims to understand the specificity of cleavage of CRISPR-based tools in the context of whole human genome. We are seeking for a bioinformatician with experience in genomics to implement tools to help in the identification of genomics regions and to study cleavage specificity of CRISPR-Cas proteins. The successful applicant will have the possibility to work in the field of genome editing and to use the state-of-the-art CRISPR tools. Furthermore, CPR has a genomics platform facility that provides high-throughput sequencing services and technical support for various genomic experiments. He she will work in a laboratory with other scientists so ability to do team work is essential. Tasks will include: DNA targets identification. Targeted NGS. Whole-genome analysis. Planning experiments. Analysis and communication of the results to the group. Experience and skills required Required: At least MSc degree in a relevant fields (such as computer science, genomics, bioinformatics etc.). Knowledge about Genomics and genomics analysis. Experience with programming languages such as Python and or R. Good communication skills, both oral and written English. CRISPR in a fast-moving field so flexibility and ability to meet deadlines are important. Enthusiasm, motivation and ability to efficiently work as part of a team. Beneficial: Knowledge of databases (i.e. SQL and or NoSQL). Experience with high-performance computing environments. Version control. Web development. Terms of salary and employment Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary starts at DKK 29,151 (approx. EUR 3,886) plus 17.1 in pension contribution. The position is time-limited to 1 year. Depending on success of the project, it may be possible to extend the employment. Working hours are 37 hours per week. Start date: October 2019. Your application Please submit your application in English with the required attachments by clicking APPLY NOW below. Only online applications will be accepted. The application must include: Short motivation letter. Curriculum vitae (including contact details of three references). Copy of relevant diplomas. We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the above-mentioned requirements. Deadline for the application: 15 August 2019, 23:59 p.m. CET. Questions For further information about the position please contact: jobs@cpr.ku.dk. University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.Presentation of the Center
Novo Nordisk Foundation Center for Protein Research (www.cpr.ku.dk) at the Faculty of Health and Medical Sciences, University of Copenhagen, performs basic and applied discovery research on human proteins of biomedical relevance. The Center comprises a wide range of expertise and resources, from in silico target identification, mass spectrometry based proteomics, structural biology, protein production and characterization to elucidation of various disease mechanisms.

One of the research areas in Montoya group is genome editing. We are using integrative structural biology approaches to understand how genome editing tools such as CRISPR-Cas12a work.

We are especially interested in explore how CRISPR-Cas12a is able to recognize and cut a specific DNA-target (1, 2).

Stella, S., et al., Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity. Cell, 2018.

Stella, S., P. Alcon, and G. Montoya, Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage. Nature, 2017.

Job description
The project aims to understand the specificity of cleavage of CRISPR-based tools in the context of whole human genome.


We are seeking for a bioinformatician with experience in genomics to implement tools to help in the identification of genomics regions and to study cleavage specificity of CRISPR-Cas proteins. The successful applicant will have the possibility to work in the field of genome editing and to use the state-of-the-art CRISPR tools. Furthermore, CPR has a genomics platform facility that provides high-throughput sequencing services and technical support for various genomic experiments. He/she will work in a laboratory with other scientists so ability to do team work is essential.

Tasks will include:

  • DNA targets identification.
  • Targeted NGS.
  • Whole-genome analysis.
  • Planning experiments.
  • Analysis and communication of the results to the group.
Experience and skills required
Required:

  • At least MSc degree in a relevant fields (such as computer science, genomics, bioinformatics etc.).
  • Knowledge about Genomics and genomics analysis.
  • Experience with programming languages such as Python and/or R.
  • Good communication skills, both oral and written English.
  • CRISPR in a fast-moving field so flexibility and ability to meet deadlines are important.
  • Enthusiasm, motivation and ability to efficiently work as part of a team.
Beneficial:

  • Knowledge of databases (i.e. SQL and/or NoSQL).
  • Experience with high-performance computing environments.
  • Version control.
  • Web development.
Terms of salary and employment
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary starts at DKK 29,151 (approx. EUR 3,886) plus 17.1 % in pension contribution.

The position is time-limited to 1 year. Depending on success of the project, it may be possible to extend the employment. Working hours are 37 hours per week.

Start date: October 2019.

Your application
Please submit your application in English with the required attachments by clicking "APPLY NOW" below. Only online applications will be accepted.

The application must include:

  1. Short motivation letter.
  2. Curriculum vitae (including contact details of three references).
  3. Copy of relevant diplomas.
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the above-mentioned requirements.

Deadline for the application: 15 August 2019, 23:59 p.m. CET.

Questions
For further information about the position please contact: jobs@cpr.ku.dk.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.







KU - SUND - PANUM KBH NKøbenhavn N2019-07-05T00:00:002019-08-15T00:00:00
330054180Research assistant for Structural Biology of Molecular Machines Group at CPRRobot Presentation of the Center Novo Nordisk Foundation Center for Protein Research (www.cpr.ku.dk) at the Faculty of Health and Medical Sciences, University of Copenhagen, performs basic and applied discovery research on human proteins of biomedical relevance. The Center comprises a wide range of expertise and resources, from in silico target identification, mass spectrometry based proteomics, structural biology, protein production and characterization to elucidation of various disease mechanisms. The Taylor group is studying the structure and mechanism of biological molecular machines using cryo-electron microscopy. We are especially interested in resolving structural and functional pathways of bacteriophages1 (bacterial viruses) and human membrane proteins2. Taylor, N. M. I. et al. Structure of the T4 baseplate and its function in triggering sheath contraction. Nature533, 346 352 (2016). Taylor, N. M. I. et al. Structure of the human multidrug transporter ABCG2. Nature546, 504 509 (2017). Job description We are seeking a Research assistant to: Plan and perform laboratory work within the areas of cloning, cell culture, recombinant expression, and protein purification of soluble and membrane proteins and complexes. Techniques used will include Gibson assembly cloning, sequence- and ligation-independent cloning and other cloning methods, CRISPR Cas9-based bacterial genome modification, protein purification (including affinity purification, ion exchange, size exclusion chromatography), gradient-based ultracentrifugation, reconstitution of proteins into nanodiscs and proteolipsomes, bacteriophage production. Perform negative-stain and cryo sample preparation for electron microscopy. Undertake electron microscopic imaging of negative-stain and cryo samples. Evaluate and report experimental results and ensuring that research data and protocols are entered into an (electronic) lab notebook. Help to maintain stocks, reagents, media and laboratory equipment. Share responsibility within the team in terms of defining objectives and meet deadlines. Participate in the general operation and maintenance of the laboratory facilities. Carry out any other relevant duties as may reasonably be associated with the position and which may be required from time to time. Experience and skills Required: MSc degree is required. Solid and documented work experience from high quality academic and or industrial laboratories is required. Proven experience in molecular biology and cell culture laboratory work. Experience in protein purification and characterization. Computer proficiency (Word, Excel). Experience with research database systems would be considered an asset. Good communication skills, both oral and written. Considering that the Center is a highly international research environment, good knowledge of English is required. Integrity, reliability, enthusiasm, motivation, flexibility, confidence, capability to learn new methods and good collaboration skills. The ability to efficiently work as part of a team is essential. Beneficial: Experience with bacteriophages. Experience with membrane protein purification, nanodisc and or liposome reconstitution. Experience with negative stain and or cryo-electron microscopy sample preparation. Terms of salary and employment Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary starts at DKK 29,151 (approx. EUR 3,886) plus 17.1 in pension contribution. The position is time-limited to 1 year. Depending on success of the project, it may be possible to extend the employment. Working hours are 37 hours per week. Start date: 1 October 2019. Your application Please submit your application in English with the required attachments by clicking APPLY NOW below. Only online applications will be accepted. The application must include: Motivation letter. Curriculum vitae (including contact details of three references). Copy of relevant diplomas. We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the above-mentioned requirements. Deadline for the application: 31 July 2019, 23:59 p.m. CET. Questions For further information about the position please contact: jobs@cpr.ku.dk. University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.Presentation of the Center
Novo Nordisk Foundation Center for Protein Research (www.cpr.ku.dk) at the Faculty of Health and Medical Sciences, University of Copenhagen, performs basic and applied discovery research on human proteins of biomedical relevance. The Center comprises a wide range of expertise and resources, from in silico target identification, mass spectrometry based proteomics, structural biology, protein production and characterization to elucidation of various disease mechanisms.

The Taylor group is studying the structure and mechanism of biological molecular machines using cryo-electron microscopy. We are especially interested in resolving structural and functional pathways of bacteriophages1 (bacterial viruses) and human membrane proteins2.

Taylor, N. M. I. et al. Structure of the T4 baseplate and its function in triggering sheath contraction. Nature533, 346–352 (2016).

Taylor, N. M. I. et al. Structure of the human multidrug transporter ABCG2. Nature546, 504–509 (2017).

Job description
We are seeking a Research assistant to:


  • Plan and perform laboratory work within the areas of cloning, cell culture, recombinant expression, and protein purification of soluble and membrane proteins and complexes. Techniques used will include Gibson assembly cloning, sequence- and ligation-independent cloning and other cloning methods, CRISPR/Cas9-based bacterial genome modification, protein purification (including affinity purification, ion exchange, size exclusion chromatography), gradient-based ultracentrifugation, reconstitution of proteins into nanodiscs and proteolipsomes, bacteriophage production.
  • Perform negative-stain and cryo sample preparation for electron microscopy.
  • Undertake electron microscopic imaging of negative-stain and cryo samples.
  • Evaluate and report experimental results and ensuring that research data and protocols are entered into an (electronic) lab notebook.
  • Help to maintain stocks, reagents, media and laboratory equipment.
  • Share responsibility within the team in terms of defining objectives and meet deadlines.
  • Participate in the general operation and maintenance of the laboratory facilities.
  • Carry out any other relevant duties as may reasonably be associated with the position and which may be required from time to time.
Experience and skills
Required:


  • MSc degree is required.
  • Solid and documented work experience from high quality academic and/or industrial laboratories is required.
  • Proven experience in molecular biology and cell culture laboratory work.
  • Experience in protein purification and characterization.
  • Computer proficiency (Word, Excel).
  • Experience with research database systems would be considered an asset.
  • Good communication skills, both oral and written. Considering that the Center is a highly international research environment, good knowledge of English is required.
  • Integrity, reliability, enthusiasm, motivation, flexibility, confidence, capability to learn new methods and good collaboration skills.
  • The ability to efficiently work as part of a team is essential.
Beneficial:

  • Experience with bacteriophages.
  • Experience with membrane protein purification, nanodisc and/or liposome reconstitution.
  • Experience with negative stain and/or cryo-electron microscopy sample preparation.
Terms of salary and employment
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary starts at DKK 29,151 (approx. EUR 3,886) plus 17.1 % in pension contribution.

The position is time-limited to 1 year. Depending on success of the project, it may be possible to extend the employment. Working hours are 37 hours per week.

Start date: 1 October 2019.

Your application
Please submit your application in English with the required attachments by clicking "APPLY NOW" below. Only online applications will be accepted.

The application must include:

  1. Motivation letter.
  2. Curriculum vitae (including contact details of three references).
  3. Copy of relevant diplomas.
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the above-mentioned requirements.

Deadline for the application: 31 July 2019, 23:59 p.m. CET.

Questions
For further information about the position please contact: jobs@cpr.ku.dk.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.

KU - SUND - PANUM KBH NKøbenhavn N2019-07-05T00:00:002019-07-31T00:00:00
330052890PhD fellowship in Food MicrobiologyRobot Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences (SUND), University of Copenhagen We are offering a PhD fellowship in food microbiology commencing 1 October 2019 or as soon as possible hereafter. Our group and research Our group include currently one professor, one associate professor, one post-doctoral fellow and three PhD students. We focus on public veterinary health which include the issue of food control as well as various aspects of bacterial pathogenic and spoilage bacteria and their effects on food safety and quality. Project description The PhD student will work on an investigation of the usability of an objective chemical criteria aiming at reducing food waste due to microbial spoilage. Microbial spoilage of meat and fish products is a result of unconstrained bacterial growth after slaughter catch. Direct enumeration of bacteria is the only way that the industry can know if their product is of satisfactory microbial quality, however it is expensive, time consuming and ultimately imprecise. The sell-by date or best before date (coming before the use-by date) is usually estimated by inaccurate non-objective sensory analysis methods and or based on a set number of days before the defined use-by date. These estimations are not fitted to the precise conditions of storage or treatment of the producer. In terms of alternative methods with clear future potential, production of biogenic amines by microorganisms in and on meat and fish might be successfully exploited as pronounced spoilage markers, since the concentration of these potentially correlate with the numbers of spoilage bacterial. The specific aim of this project is to use the level of biogenic amines in different types of Chinese and Danish meat and fish products under various storage conditions as an objective chemical criterion. For the PhD project, three main activities are planned: To unravel the similarities and differences in sensory characteristics and content of biogenic amines and bacteria producing those compounds in selected Danish and Chinese foods. To conduct microbial and molecular - including metagenomic - characterization of the bacterial flora in the products examined in part 1 in order to characterize their spoilage potential and usability in terms of establishing a quality criteria based on biogenic amines. Challenge experiments including selected Danish and Chinese food products to establish quality criteria and shelf-life based on content of biogenic amines. Usage of a prototype sensor for this purpose will also be examined. The PhD study will potentially demonstrate a technology that will be more accurate, cheaper and far quicker than any of the current technologies to assess quality and shelf-life of Chinese and Danish food products. The safe extension of these dates will have direct and significant impact in waste reduction in production, retail and private households. The PhD student is expected to deliver 3-4 publications in high-ranking food and microbiologically oriented journals. Principal supervisor is Associate professor, Jørgen Leisner PhD, Department of Veterinary and Animal Sciences, University of Copenhagen, E-mail: jjl@sund.ku.dk, Phone: 45 3533 2768, Mobile 45 6027 9174. Professor Derek Byrne at Department of Food Science, Aarhus University will be an additional supervisor. Start: 1 October 2019 Duration: 3 years as a PhD student Job description Your key tasks as a PhD student at SUND are: Carry through an independent research project under supervision Write scientific articles and the PhD thesis on the grounds of your project Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points Participate in active research environments including a stay at another research team abroad Obtain experience with teaching or other types of dissemination related to your PhD project Participate in the undergraduate teaching of students within the subject of food micriobiology Key criteria for the assessment of applicants Applicants must have qualifications corresponding to a master s degree related to the subject area of the project. Other important criteria are: The grade point average achieved Professional qualifications relevant to the PhD project Previous publications Relevant work experience Other professional activities Curious mind-set with a strong interest in food safety and quality Language skills The successfull applicant is also required to be enterprising and to possess good interpersonal skills Place of employment The place of employment is for the main part at Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories. The PhD student will spend one year in China at the Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. Terms of employment The employment as PhD fellow is full time and for 3 years. It is conditioned upon the applicant s success ful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant. The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty s rules on achieving the degree. Salary, pension and terms of employment are in accordance with the agree ment between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around 26.755 DKK approx. 3.567 EUR (April 2018-level) plus pension. Questions For specific information about the PhD fellowship, please contact the principal supervisor. General information about PhD study at the Faculty of Health and Medical Sciences is available at the Graduate School s website: https: healthsciences.ku.dk phd guidelines Application procedure Your application, in English, must be submitted electronically by clicking Apply now below. The application must include the following documents in PDF format: 1. Motivated letter of application (max. one page) 2. CV incl. education, experience, language skills and other skills relevant for the position 3. Master of Science diploma and transcript of records. If not completed, a certified signed copy of a recent transcript of records or a written statement from the institution or supervisor will do 4. Publication list (if possible) Application deadline: 31st July, 2019, 23.59pm CET We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements. The further process After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him herself. You can read about the recruitment process at http: employment.ku.dk faculty recruitment-process The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities. Interviews are expected to be held in the period 12th 16th August, 2019 The Faculty of Health and Medical Sciences comprises approximately 7500 students, 1500 PhD students and 3200 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community. The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position.Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences (SUND), University of Copenhagen

We are offering a PhD fellowship in food microbiology commencing 1 October 2019 or as soon as possible hereafter.

Our group and research

Our group include currently one professor, one associate professor, one post-doctoral fellow and three PhD students. We focus on public veterinary health which include the issue of food control as well as various aspects of bacterial pathogenic and spoilage bacteria and their effects on food safety and quality.

Project description

The PhD student will work on an investigation of the usability of an objective chemical criteria aiming at reducing food waste due to microbial spoilage.

Microbial spoilage of meat and fish products is a result of unconstrained bacterial growth after slaughter/catch. Direct enumeration of bacteria is the only way that the industry can know if their product is of satisfactory microbial quality, however it is expensive, time consuming and ultimately imprecise. The sell-by date or best before date (coming before the use-by date) is usually estimated by inaccurate non-objective sensory analysis methods and/or based on a set number of days before the defined use-by date. These estimations are not fitted to the precise conditions of storage or treatment of the producer. In terms of alternative methods with clear future potential, production of biogenic amines by microorganisms in and on meat and fish might be successfully exploited as pronounced spoilage markers, since the concentration of these potentially correlate with the numbers of spoilage bacterial.

The specific aim of this project is to use the level of biogenic amines in different types of Chinese and Danish meat and fish products under various storage conditions as an objective chemical criterion. For the PhD project, three main activities are planned:

  1. To unravel the similarities and differences in sensory characteristics and content of biogenic amines and bacteria producing those compounds in selected Danish and Chinese foods.
  2. To conduct microbial and molecular - including metagenomic - characterization of the bacterial flora in the products examined in part 1 in order to characterize their spoilage potential and usability in terms of establishing a quality criteria based on biogenic amines.
  3. Challenge experiments including selected Danish and Chinese food products to establish quality criteria and shelf-life based on content of biogenic amines. Usage of a prototype sensor for this purpose will also be examined.
The PhD study will potentially demonstrate a technology that will be more accurate, cheaper and far quicker than any of the current technologies to assess quality and shelf-life of Chinese and Danish food products. The safe extension of these dates will have direct and significant impact in waste reduction in production, retail and private households. The PhD student is expected to deliver 3-4 publications in high-ranking food and microbiologically oriented journals.

Principal supervisor is Associate professor, Jørgen Leisner PhD, Department of Veterinary and Animal Sciences, University of Copenhagen, E-mail: jjl@sund.ku.dk, Phone: +45 3533 2768, Mobile +45 6027 9174. Professor Derek Byrne at Department of Food Science, Aarhus University will be an additional supervisor.

Start: 1 October 2019

Duration: 3 years as a PhD student

Job description

Your key tasks as a PhD student at SUND are:

  • Carry through an independent research project under supervision
  • Write scientific articles and the PhD thesis on the grounds of your project
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
  • Participate in active research environments including a stay at another research team abroad
  • Obtain experience with teaching or other types of dissemination related to your PhD project
  • Participate in the undergraduate teaching of students within the subject of food micriobiology
Key criteria for the assessment of applicants

Applicants must have qualifications corresponding to a master’s degree related to the subject area of the project.

Other important criteria are:

  • The grade point average achieved
  • Professional qualifications relevant to the PhD project
  • Previous publications
  • Relevant work experience
  • Other professional activities
  • Curious mind-set with a strong interest in food safety and quality
  • Language skills
  • The successfull applicant is also required to be enterprising and to possess good interpersonal skills
Place of employment

The place of employment is for the main part at Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories. The PhD student will spend one year in China at the Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

Terms of employment

The employment as PhD fellow is full time and for 3 years.

It is conditioned upon the applicant’s success­ful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.

The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty’s rules on achieving the degree. Salary, pension and terms of employment are in accordance with the agree­ment between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around 26.755 DKK /approx. 3.567 EUR (April 2018-level) plus pension.

Questions

For specific information about the PhD fellowship, please contact the principal supervisor.

General information about PhD study at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/

Application procedure

Your application, in English, must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format:

1. Motivated letter of application (max. one page)

2. CV incl. education, experience, language skills and other skills relevant for the position

3. Master of Science diploma and transcript of records. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor will do

4. Publication list (if possible)

Application deadline: 31st July, 2019, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.

The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

Interviews are expected to be held in the period 12th – 16th August, 2019

The Faculty of Health and Medical Sciences comprises approximately 7500 students, 1500 PhD students and 3200 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community. The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position.


KU - SUND - IVSFrederiksberg C2019-07-02T00:00:002019-07-31T00:00:00
da-DK

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