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Postdoc at Center for Cancer Immune Therapy

Postdoc position – Tumor stroma as a modulator of immunotherapy efficiency.  
We are looking for a highly motivated candidate for a postdoc position within the field of cancer biology/cancer immunology. The applicant must have a background in cancer biology or immunology. Prior research expertise with mouse work is an advantage.  
The research group: The project will be carried out in the Tumor Stroma and Matrix Immunology (TSMI) group at the Center for Cancer Immunotherapy (CCIT), Copenhagen University Hospital, Herlev, Denmark, a research center with a strong background in experimental and clinical cancer immunotherapy research. Five different clinical immunotherapy trials are currently running at CCIT, many of which originate from our own pre-clinical research results. More information about the center can be found on The TSMI group is headed by Daniel H. Madsen, and the goal of the research group is to discover molecular mechanisms, by which the tumor microenvironment influences immunotherapy efficiency, and to use this knowledge to develop new therapeutic strategies. The TSMI group is currently studying how different subsets of macrophages, fibroblasts and the extracellular matrix affect the activity of tumor infiltrating T cells. The research projects are mainly based on transgenic mouse models, 3D cell culture, and the use of clinical samples from cancer patients. The TSMI group is a small international group currently consisting of one postdoc, two PhD students, and two Master’s students.  
The research project: Cancer immunotherapy has had a major breakthrough within the last decade with the discoveries that endogenous cytotoxic T cells possess the ability to react against cancer cells and that the blocking of immunosuppressive signals can be sufficient for obtaining extremely impressive clinical results. Still, however, many cancer patients do not respond to immunotherapy. One likely reason for this is that the local T cell response in the tumor gets suppressed by components of the tumor microenvironment.  
The selected candidate will work on a project within the focus area of the TSMI group. The precise project will be defined after discussions between applicant and supervisor, taking into consideration the interests and expertise of the applicant.  
The project will involve methods such as 3D cell culture assays, RNA-sequencing, mouse cancer models, flow cytometry, immunohistochemistry, co-culture assays, cytokine profiling, and FACS-isolation of specific cell populations for functional assays.  
Salary: Salary, pension and terms of employment will be in accordance with the regional AC-agreement.
Start date: May 1st, 2018 or after agreement.  
Duration: 2 years, with the possibility for extension.  
Application deadline: February 20th, 2018. The application should include a motivated letter of application (max. 1 page), a CV, and at least 2 letters of recommendation.  
For further information regarding the position, please contact Daniel H. Madsen.  
E-mail: or Tel: (+45) 38686367.  

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