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Postdoc for the scale-up of mammalian cell cultivation processes

A post-doctorate position is available within the field of mammalian cell cultivation at Novo Nordisk. The aim is to identify the key engineering parameters to enable a successful scale-up and tech transfer of mammalian cell cultivation processes from process development scale to manufacturing scale.

About the department
The Mammalian Cultivation Development department is focused on the development of mammalian cell cultivation processes for cell lines received from Global Research and on developing processes amenable to operation in the Product Supply departments or at a contract manufacturing organisation.

The position
The project aim is to increase our understanding of key parameters when transferring a mammalian cell process developed at the laboratory scale to a production scale bioreactor. This can be challenging especially when the bioreactors in different scales are geometrically dissimilar. A model of the key scale-up parameters will be generated, allowing the transfer of a cultivation process to large scale bioreactors with reduced process variation and titres equivalent to lab scale. A predictive scale-up model will be developed using existing small scale lab systems, currently used for clone screening purposes. These systems will have to be operationally modified to simulate large scale conditions, allowing process development and clone screening in conditions amenable to large-scale processes.

The project will be located at the mammalian cell production site in Hillerød and the postdoc will be working in the department for ‘Mammalian Cultivation Development’ in the Chemistry, Manufacturing and Control (CMC) Development area. The studies will involve a hands-on evaluation of mammalian cell cultivations with regards to the engineering characteristics and scale-up of these systems. The position will involve working in close collaboration within the development area and in the product supply areas in Hillerød and Bagsværd. Collaboration with CMO’s located outside of Denmark may also be part of the project. Developing and maintaining strong networks within different functions and areas of expertise will be an important part of your work, with good opportunities for personal and professional development.

This fellowship position is part of the Novo Nordisk R&D Science Talent Attraction and Recruitment (STAR) Programme, which seeks talented candidates in Biotechnological, Biomedical and Engineering Sciences who want to pursue a career in pharmaceutical R&D.

The position is of two years duration.

Qualifications
The person we seek is innovative with a high focus on quality. You must have a PhD in Chemical Engineering or Life Sciences and have a strong experimental background within cell cultivation. Knowledge of mammalian cells while desirable is not essential. Specific experience for the position in terms of mathematical modelling and statistical data analysis is strongly desired, while experience in terms of scale-up of bioprocesses will be considered an advantage.

You have a proven publication record and preferably experience from working cross-culturally or in global teams.

You are motivated by working in a results-oriented process development environment. You have good interpersonal skills with a high sense of individual responsibility. Fluency in English is a prerequisite.

Working at Novo Nordisk
As part of Novo Nordisk’s R&D family, CMC Development makes a real difference for patients with chronic diseases across the world. We develop, manufacture and distribute drug candidates for non-clinical and clinical trials, which is a complicated journey that requires about 10 years of dedicated work in CMC Development. CMC Development is an ambitious organisation with a strong culture. We always seek to solve problems, have an eye for the entire business and do our best to deliver despite any obstacles along the way.

Contact
For further information, please contact Giles Wilson at +45 2612 3167 or Lars Højlund Christensen at +45 3077 3080.

Deadline
15 May 2018.


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