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Postdoc in Bacteria-Cancer Interface

The Department of Biomedicine at Faculty of Health at Aarhus University invites applications for a position as Postdoc in the field of bacteria-cancer interface (host-pathogen interaction) as per 1 May 2020 or as soon as possible thereafter. The position is a fixed-term full-time position for one year with a possibility for further extension.

The ideal applicant has to be highly motivated to discover novel pathways in host-pathogen interaction and skilled in bacterial genetics. He/she should have good communication skills and be able to independently drive research projects. We are passionate about our bugs and what they can do! So we expect great enthusiasm and team spirit.

Department of Biomedicine
We offer a vibrant international research environment where English is the preferred language in the laboratory, at meetings and at seminars. The Department employs some 450 people and covers a range of research areas within Biomedicine. We contribute to the Bachelor’s degree programs in medicine, molecular medicine, odontology and the Master’s degree programs in biomedical engineering and medical chemistry. Our infrastructure is well developed with modern laboratories, core and animal facilities. You will work either in the brand new ‘Skou Building’ or similar as we are in the process of modernizing our old facilities. You can read more about the department here and about the faculty here.

About the research project
Karthika Rajeeve’s lab is focused on pathogenesis of Chlamydia infection. We investigate on two major aspects: How Chlamydia evades the host immune response? and how Chlamydial infection might contribute to malignancy in genital tract?

Chlamydia is the major cause of sexual transmitted disease worldwide, nearly 130 million new infections are reported every year. In Denmark it accounts to 35000 infection annually with ~94 infections reported per day. Chlamydia infection induces stress in the host cell that leads to DNA damage. This obligate human pathogen, de-regulate the host signaling pathways like a malignant cell, lead to depletion of tumor suppressor TP53 knocking out body’s cancer defense. In order to survive this bacterium must downregulate the TP53 tumor that mediates either cell-cycle arrest, suppression of nutrient availability or apoptosis in stressed cells. Chlamydia evades TP53-dependent apoptosis of the host similar to malignant cells. Strong evidence has accumulated suggesting fallopian tubes, the sites for chronic infections with Chlamydia are the site of origin for ovarian cancer cells. Due to lack of direct evidence and unknown key factors involved, Chlamydia remain as a ‘treatable epidemic’.

Our team is focused to comprehensively explore the molecular mechanism behind disease pathology during Chlamydia infection in a physiologically relevant way. We use cutting-edge technologies like organoids (‘mini organs’), 3D tissue models and organ on a chip to investigate how the pathogen reroute host signaling. State-of-the- art techniques like metabolomics, proteomics and single cell RNA seq will be employed to understand how the bacteria evade immune system, thus disseminating in the host. These findings might be significant outside the research settings and have implications for therapeutic interventions and developing policies to tackle this epidemic.

The laboratory for bacteria-cancer interface is led by Assistant professor Karthika Rajeeve and supported by AUFF, to ensure ample project funding. The lab is integrated with ‘Infection and Inflammation’ hosting 15 internationally competitive research groups. We offer a vibrant and highly collaborative scientific environment with excellent career development programmes.

Your job responsibilities
As Postdoc in bacteria-cancer interface your position is primarily research-based but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues on your project, where you will receive supervision and guidance.

Your main tasks will consist of:

  • Independent research of high international quality, including publications.
  • Self-driven, proactive and critical thinking
  • Vibrant ideas and participate in seminar and meetings
  • Work in collaboration with University hospital
You will report to Assistant professor Karthika Rajeeve

Your competences
You have academic qualifications at PhD level, preferably within one or more of the following areas: bacteriology, cell biology, cancer biology, immunology or relevant. Good knowledge and expertise in mammalian cell culture and/or animal models is required. Experience with bacterial genetics, organoids, 3D tissue culture, flow cytometry, bioinformatic analyses and single-cell technologies would be beneficial. Furthermore, we expect you to demonstrate a scientific track record.

As a person, you are ambitious, take ownership and possess good communication and interpersonal skills. We expect you to be fluent in oral and written English.

In order to be assessed as qualified for a Postdoc position, you must meet these academic criteria.

Shortlisting will be used.

Questions about the position
If you have any questions about the position, please contact Assistant professor Karthika Rajeeve, karaj@biomed.au.dk

Your place of work will be the Department of Biomedicine, Høegh-Guldbergs Gade 10, DK-8000 Aarhus C, Denmark.

Terms of employment
Application
Your application must include the following:
  • Motivated application
  • Curriculum Vitae
  • Diploma
  • A list of publications
  • A teaching portfolio. We refer to Guideline on the use of teaching portfolios
  • A maximum of five of the publications of greatest relevance to the job may be submitted
  • References/recommendations can be uploaded separately in the e-recruitment system
  • Template for applicant - postdoc must be completed and uploaded under ‘Extra documents’

We refer to the faculty’s Guidelines for applicants.

The assessment committee may decide to include non-submitted material in its statement. In such cases, you will be informed and obliged to submit material, unless your application is withdrawn.

All interested candidates are encouraged to apply, regardless of their personal background.

International applicant?
Aarhus University offers a broad variety of services for international researchers and accompanying families, including relocation service and career counselling to expat partners. Please find more information about entering and working in Denmark here. Aarhus University also has a Junior Researcher Development Programme. You can read more about it here.

The application must be submitted via Aarhus University’s recruitment system, which can be accessed under the job advertisement on Aarhus University's website.

Aarhus University
Aarhus University is an academically diverse and research-intensive university with a strong commitment to high-quality research and education and the development of society nationally and globally. The university offers an inspiring research and teaching environment to its 38,000 students (FTEs) and 8,000 employees, and has an annual revenues of EUR 885 million. Learn more at www.international.au.dk/

Deadline:
16 February 2020

 


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330164232Phoenix-89bfe43712020-01-24T00:00:00Postdoc in Bacteria-Cancer InterfaceThe Department of Biomedicine at Faculty of Health at Aarhus University invites applications for a position as Postdoc in the field of bacteria-cancer interface (host-pathogen interaction) as per 1 May 2020 or as soon as possible thereafter. The position is a fixed-term full-time position for one year with a possibility for further extension.

The ideal applicant has to be highly motivated to discover novel pathways in host-pathogen interaction and skilled in bacterial genetics. He/she should have good communication skills and be able to independently drive research projects. We are passionate about our bugs and what they can do! So we expect great enthusiasm and team spirit.

Department of Biomedicine
We offer a vibrant international research environment where English is the preferred language in the laboratory, at meetings and at seminars. The Department employs some 450 people and covers a range of research areas within Biomedicine. We contribute to the Bachelor’s degree programs in medicine, molecular medicine, odontology and the Master’s degree programs in biomedical engineering and medical chemistry. Our infrastructure is well developed with modern laboratories, core and animal facilities. You will work either in the brand new ‘Skou Building’ or similar as we are in the process of modernizing our old facilities. You can read more about the department here and about the faculty here.

About the research project
Karthika Rajeeve’s lab is focused on pathogenesis of Chlamydia infection. We investigate on two major aspects: How Chlamydia evades the host immune response? and how Chlamydial infection might contribute to malignancy in genital tract?

Chlamydia is the major cause of sexual transmitted disease worldwide, nearly 130 million new infections are reported every year. In Denmark it accounts to 35000 infection annually with ~94 infections reported per day. Chlamydia infection induces stress in the host cell that leads to DNA damage. This obligate human pathogen, de-regulate the host signaling pathways like a malignant cell, lead to depletion of tumor suppressor TP53 knocking out body’s cancer defense. In order to survive this bacterium must downregulate the TP53 tumor that mediates either cell-cycle arrest, suppression of nutrient availability or apoptosis in stressed cells. Chlamydia evades TP53-dependent apoptosis of the host similar to malignant cells. Strong evidence has accumulated suggesting fallopian tubes, the sites for chronic infections with Chlamydia are the site of origin for ovarian cancer cells. Due to lack of direct evidence and unknown key factors involved, Chlamydia remain as a ‘treatable epidemic’.

Our team is focused to comprehensively explore the molecular mechanism behind disease pathology during Chlamydia infection in a physiologically relevant way. We use cutting-edge technologies like organoids (‘mini organs’), 3D tissue models and organ on a chip to investigate how the pathogen reroute host signaling. State-of-the- art techniques like metabolomics, proteomics and single cell RNA seq will be employed to understand how the bacteria evade immune system, thus disseminating in the host. These findings might be significant outside the research settings and have implications for therapeutic interventions and developing policies to tackle this epidemic.

The laboratory for bacteria-cancer interface is led by Assistant professor Karthika Rajeeve and supported by AUFF, to ensure ample project funding. The lab is integrated with ‘Infection and Inflammation’ hosting 15 internationally competitive research groups. We offer a vibrant and highly collaborative scientific environment with excellent career development programmes.

Your job responsibilities
As Postdoc in bacteria-cancer interface your position is primarily research-based but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues on your project, where you will receive supervision and guidance.

Your main tasks will consist of:
  • Independent research of high international quality, including publications.
  • Self-driven, proactive and critical thinking
  • Vibrant ideas and participate in seminar and meetings
  • Work in collaboration with University hospital
You will report to Assistant professor Karthika Rajeeve

Your competences
You have academic qualifications at PhD level, preferably within one or more of the following areas: bacteriology, cell biology, cancer biology, immunology or relevant. Good knowledge and expertise in mammalian cell culture and/or animal models is required. Experience with bacterial genetics, organoids, 3D tissue culture, flow cytometry, bioinformatic analyses and single-cell technologies would be beneficial. Furthermore, we expect you to demonstrate a scientific track record.

As a person, you are ambitious, take ownership and possess good communication and interpersonal skills. We expect you to be fluent in oral and written English.

In order to be assessed as qualified for a Postdoc position, you must meet these academic criteria.

Shortlisting will be used.

Questions about the position
If you have any questions about the position, please contact Assistant professor Karthika Rajeeve, karaj@biomed.au.dk

Your place of work will be the Department of Biomedicine, Høegh-Guldbergs Gade 10, DK-8000 Aarhus C, Denmark.

Terms of employment
Application
Your application must include the following:
  • Motivated application
  • Curriculum Vitae
  • Diploma
  • A list of publications
  • A teaching portfolio. We refer to Guideline on the use of teaching portfolios
  • A maximum of five of the publications of greatest relevance to the job may be submitted
  • References/recommendations can be uploaded separately in the e-recruitment system
  • Template for applicant - postdoc must be completed and uploaded under ‘Extra documents’

We refer to the faculty’s Guidelines for applicants.

The assessment committee may decide to include non-submitted material in its statement. In such cases, you will be informed and obliged to submit material, unless your application is withdrawn.

All interested candidates are encouraged to apply, regardless of their personal background.

International applicant?
Aarhus University offers a broad variety of services for international researchers and accompanying families, including relocation service and career counselling to expat partners. Please find more information about entering and working in Denmark here. Aarhus University also has a Junior Researcher Development Programme. You can read more about it here.

The application must be submitted via Aarhus University’s recruitment system, which can be accessed under the job advertisement on Aarhus University's website.

Aarhus University
Aarhus University is an academically diverse and research-intensive university with a strong commitment to high-quality research and education and the development of society nationally and globally. The university offers an inspiring research and teaching environment to its 38,000 students (FTEs) and 8,000 employees, and has an annual revenues of EUR 885 million. Learn more at www.international.au.dk/

Deadline:
16 February 2020

 

2020-02-17T00:56:33.390 The Department of Biomedicine at Faculty of Health at Aarhus University invites applications for a position as Postdoc in the field of bacteria-cancer interface (host-pathogen interaction) as per 1 May 2020 or as soon as possible thereafter. The position is a fixed-term full-time position for one year with a possibility for further extension. The ideal applicant has to be highly motivated to discover novel pathways in host-pathogen interaction and skilled in bacterial genetics. He she should have good communication skills and be able to independently drive research projects. We are passionate about our bugs and what they can do! So we expect great enthusiasm and team spirit. Department of Biomedicine We offer a vibrant international research environment where English is the preferred language in the laboratory, at meetings and at seminars. The Department employs some 450 people and covers a range of research areas within Biomedicine. We contribute to the Bachelor s degree programs in medicine, molecular medicine, odontology and the Master s degree programs in biomedical engineering and medical chemistry. Our infrastructure is well developed with modern laboratories, core and animal facilities. You will work either in the brand new Skou Building or similar as we are in the process of modernizing our old facilities. You can read more about the department here and about the faculty here. About the research project Karthika Rajeeve s lab is focused on pathogenesis of Chlamydia infection. We investigate on two major aspects: How Chlamydia evades the host immune response? and how Chlamydial infection might contribute to malignancy in genital tract? Chlamydia is the major cause of sexual transmitted disease worldwide, nearly 130 million new infections are reported every year. In Denmark it accounts to 35000 infection annually with ~94 infections reported per day. Chlamydia infection induces stress in the host cell that leads to DNA damage. This obligate human pathogen, de-regulate the host signaling pathways like a malignant cell, lead to depletion of tumor suppressor TP53 knocking out body s cancer defense. In order to survive this bacterium must downregulate the TP53 tumor that mediates either cell-cycle arrest, suppression of nutrient availability or apoptosis in stressed cells. Chlamydia evades TP53-dependent apoptosis of the host similar to malignant cells. Strong evidence has accumulated suggesting fallopian tubes, the sites for chronic infections with Chlamydia are the site of origin for ovarian cancer cells. Due to lack of direct evidence and unknown key factors involved, Chlamydia remain as a treatable epidemic . Our team is focused to comprehensively explore the molecular mechanism behind disease pathology during Chlamydia infection in a physiologically relevant way. We use cutting-edge technologies like organoids ( mini organs ), 3D tissue models and organ on a chip to investigate how the pathogen reroute host signaling. State-of-the- art techniques like metabolomics, proteomics and single cell RNA seq will be employed to understand how the bacteria evade immune system, thus disseminating in the host. These findings might be significant outside the research settings and have implications for therapeutic interventions and developing policies to tackle this epidemic. The laboratory for bacteria-cancer interface is led by Assistant professor Karthika Rajeeve and supported by AUFF, to ensure ample project funding. The lab is integrated with Infection and Inflammation hosting 15 internationally competitive research groups. We offer a vibrant and highly collaborative scientific environment with excellent career development programmes. Your job responsibilities As Postdoc in bacteria-cancer interface your position is primarily research-based but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues on your project, where you will receive supervision and guidance. Your main tasks will consist of:Independent research of high international quality, including publications.Self-driven, proactive and critical thinkingVibrant ideas and participate in seminar and meetingsWork in collaboration with University hospitalYou will report to Assistant professor Karthika Rajeeve Your competences You have academic qualifications at PhD level, preferably within one or more of the following areas: bacteriology, cell biology, cancer biology, immunology or relevant. Good knowledge and expertise in mammalian cell culture and or animal models is required. Experience with bacterial genetics, organoids, 3D tissue culture, flow cytometry, bioinformatic analyses and single-cell technologies would be beneficial. Furthermore, we expect you to demonstrate a scientific track record. As a person, you are ambitious, take ownership and possess good communication and interpersonal skills. We expect you to be fluent in oral and written English. In order to be assessed as qualified for a Postdoc position, you must meet these academic criteria. Shortlisting will be used. Questions about the position If you have any questions about the position, please contact Assistant professor Karthika Rajeeve, karaj@biomed.au.dk Your place of work will be the Department of Biomedicine, Høegh-Guldbergs Gade 10, DK-8000 Aarhus C, Denmark. Terms of employment Appointment as a postdoc requires academic qualifications at PhD level.Further information on the appointment procedure can be found in the Ministerial Order on the Appointment of Academic Staff at Universities.The appointment is in accordance with the Danish Confederation of Professional Associations (Akademikerne).Remuneration is in accordance with the above, and the Salary agreement catalogue for staff at Health.Further information on qualification requirements and job description can be found in the Memorandum on Job Structure for Academic Staff at Danish Universities. Application Your application must include the following:Motivated applicationCurriculum VitaeDiplomaA list of publicationsA teaching portfolio. We refer to Guideline on the use of teaching portfoliosA maximum of five of the publications of greatest relevance to the job may be submittedReferences recommendations can be uploaded separately in the e-recruitment systemTemplate for applicant - postdoc must be completed and uploaded under Extra documents We refer to the faculty s Guidelines for applicants. The assessment committee may decide to include non-submitted material in its statement. In such cases, you will be informed and obliged to submit material, unless your application is withdrawn. All interested candidates are encouraged to apply, regardless of their personal background. International applicant? Aarhus University offers a broad variety of services for international researchers and accompanying families, including relocation service and career counselling to expat partners. Please find more information about entering and working in Denmark here. Aarhus University also has a Junior Researcher Development Programme. You can read more about it here. The application must be submitted via Aarhus University s recruitment system, which can be accessed under the job advertisement on Aarhus University s website. Aarhus University Aarhus University is an academically diverse and research-intensive university with a strong commitment to high-quality research and education and the development of society nationally and globally. The university offers an inspiring research and teaching environment to its 38,000 students (FTEs) and 8,000 employees, and has an annual revenues of EUR 885 million. Learn more at www.international.au.dk Deadline: 16 February 202011Jobnet89bfe437100000000000IDK_OFIR_02DKDanmark228DKK2020-02-16T00:00:000000https://au.emply.net/recruitment/vacancyApply.aspx?publishingId=85924e5b-f6f0-46a9-948e-9afc303ef5890EuropaDanmarkJyllandØstjyllandAarhus3697898Aarhus Universitet11Høegh-Guldbergs Gade 108000Aarhus CDKDanmark0
karaj@biomed.au.dkDKDanmarkDKDanmark
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