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Postdoc in Immuno-Onco-Virology

The Department of Biomedicine at Faculty of Health at Aarhus University invites applications for a position as Postdoc in the field of immuno-onco-virology as per 1 November 2022 or as soon as possible thereafter. The position is a 2-year fixed-term full-time position with possibility of extension.

The department of Biomedicine prioritises diversity and a good work environment, as this is a prerequisite for groundbreaking research. In a dynamic and international research environment, dedicated employees are looking to generate new knowledge within biomedical research areas such as infection and inflammation, membranes, neuroscience and personalised medicine. The Department of Biomedicine provides research-based teaching of the highest quality and is responsible for a large part of the medical degree programme. Academic staff contribute to the teaching. English is the preferred language in the laboratory, at meetings and at seminars. The department employs approx. 500 people from all over the world, and they make use of the department's modern laboratory-, core- and animal facilities. The Department of Biomedicine focuses on innovation, entrepreneurship and collaboration with business and industry, and numerous researchers from the department have established companies to develop new medicinal treatments founded in strong scientific basic research. You can read more about the department here and about the faculty here.
 

About the research project

The use of OVs in cancer therapy is an emerging therapeutic approach that has demonstrated significant antitumor effects and safety in phases I-III clinical trials. OVs are tumor-selective, self-amplifying therapeutics that selectively kill cancer cells via direct oncolysis, shutdown of tumor vasculature and stimulate immune responses against tumor antigens. An essential aspect in the development of these agents is safety, thus clinically relevant viruses are genetically engineered to remove any pathogenic viral functions and be highly sensitive to interferon (IFN), the major antiviral host defence system. These alterations render the virus safe to be administered to patients, but unfortunately can affect viral replication and spread within tumour tissues. This constitutes a critical limitation to these agents. Because significant replication of oncolytic viruses in tumour tissues is necessary for highest efficacy, the identification of strategies that significantly potentiate viral replication of clinically relevant and safe viruses, specifically within malignant tissues, could substantially improve oncolysis and stimulate stronger anti-tumour immune responses. In the opened position, we will identify resistance factor to OV therapy in cancer cells using genome-wide CRISPR-Cas9 screens or compound library screen and genetically engineer novel OVs to unleash their oncolytic potential. These novel viruses will be tested as anticancer treatment agents in vitro in cancer cell lines, ex vivo in patient-derived cancer material and in vivo in murine and zebra fish models.
 

Your job responsibilities

As Postdoc immuno-onco-virology your position is primarily research-based but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues on your project, where you will receive supervision and guidance.

Your main tasks will consist of:

  • Independent research of high international quality, including publication.
  • Teaching and supervision of junior lab members.
  • Training in writing small grant applications

You will report to Associate Professor David Olagnier
 

Your competences

You have academic qualifications at PhD level, preferably within one or more of the following areas: molecular medicine, molecular biology, biochemistry, immunology, virology; and with a strong interest in cancer immunology and novel therapeutic options. Applicants with documented experience in animal models in vivo or with genome wide CRISPR-screens will be preferred.

You should be enthusiastic, motivated, result-driven and creative minded, with good organization, writing and communication skills. You should be interested in fundamental and translational research questions and be able to work both independently and in a team environment.

As a person, you are ambitious, take ownership and possess good communication and interpersonal skills. We expect you to be fluent in oral and written English.

In order to be assessed as qualified for a Postdoc position, you must meet these academic criteria.

Shortlisting will be used
 

Questions about the position

If you have any questions about the position, please contact David Olagnier; olagnier@biomed.au.dk

Your place of work will be the Department of Biomedicine, SKOU bygning, DK-8000 Aarhus C, Denmark.

We expect to conduct interviews in August and September 2022.
 



Terms of employment





Application


Your application must include the following:
  • Motivated application
  • Curriculum Vitae
  • Diploma
  • Template for applicant - postdoc must be completed and uploaded under ‘Extra documents’
  • A list of publications
  • A teaching portfolio. We refer to Guideline on the use of teaching portfolios
  • A maximum of five of the publications of greatest relevance to the job may be submitted (optional)
  • Strategic research plan can be uploaded (optional)
  • Coauthor statement(s) can be uploaded (optional)
  • References/recommendations can be uploaded separately in the e-recruitment system (optional)
We refer to the faculty’s Guidelines for applicants.

The assessment committee may decide to include non-submitted material in its statement. In such cases, you will be informed and obliged to submit material, unless your application is withdrawn.

Aarhus University’s ambition is to be an attractive and inspiring workplace for all and to foster a culture in which each individual has opportunities to thrive, achieve and develop. We view equality and diversity as assets, and we welcome all applicants.
 

Letter of reference

If you want a referee to upload a letter of reference on your behalf, please state the referee’s contact information when you submit your application. We strongly recommend that you make an agreement with the person in question before you enter the referee’s contact information, and that you ensure that the referee has enough time to write the letter of reference before the application deadline.
Unfortunately, it is not possible to ensure that letters of reference received after the application deadline will be taken into consideration.


International applicant?


Aarhus University offers a broad variety of services for international researchers and accompanying families, including relocation service and career counselling to expat partners. Please find more information about entering and working in Denmark here. Aarhus University also has a Junior Researcher Development Programme. You can read more about it here.

The application must be submitted via Aarhus University’s recruitment system, which can be accessed under the job advertisement on Aarhus University's website.

 
Aarhus University
Aarhus University is an academically diverse and research-intensive university with a strong commitment to high-quality research and education and the development of society nationally and globally. The university offers an inspiring research and teaching environment to its 38,000 students (FTEs) and 8,000 employees, and has an annual revenues of EUR 885 million. Learn more at www.international.au.dk/

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Postdoc in Immuno-Onco-Virology

The Department of Biomedicine at Faculty of Health at Aarhus University invites applications for a position as Postdoc in the field of immuno-onco-virology as per 1 November 2022 or as soon as possible thereafter. The position is a 2-year fixed-term full-time position with possibility of extension.

The department of Biomedicine prioritises diversity and a good work environment, as this is a prerequisite for groundbreaking research. In a dynamic and international research environment, dedicated employees are looking to generate new knowledge within biomedical research areas such as infection and inflammation, membranes, neuroscience and personalised medicine. The Department of Biomedicine provides research-based teaching of the highest quality and is responsible for a large part of the medical degree programme. Academic staff contribute to the teaching. English is the preferred language in the laboratory, at meetings and at seminars. The department employs approx. 500 people from all over the world, and they make use of the department's modern laboratory-, core- and animal facilities. The Department of Biomedicine focuses on innovation, entrepreneurship and collaboration with business and industry, and numerous researchers from the department have established companies to develop new medicinal treatments founded in strong scientific basic research. You can read more about the department here and about the faculty here.
 

About the research project

The use of OVs in cancer therapy is an emerging therapeutic approach that has demonstrated significant antitumor effects and safety in phases I-III clinical trials. OVs are tumor-selective, self-amplifying therapeutics that selectively kill cancer cells via direct oncolysis, shutdown of tumor vasculature and stimulate immune responses against tumor antigens. An essential aspect in the development of these agents is safety, thus clinically relevant viruses are genetically engineered to remove any pathogenic viral functions and be highly sensitive to interferon (IFN), the major antiviral host defence system. These alterations render the virus safe to be administered to patients, but unfortunately can affect viral replication and spread within tumour tissues. This constitutes a critical limitation to these agents. Because significant replication of oncolytic viruses in tumour tissues is necessary for highest efficacy, the identification of strategies that significantly potentiate viral replication of clinically relevant and safe viruses, specifically within malignant tissues, could substantially improve oncolysis and stimulate stronger anti-tumour immune responses. In the opened position, we will identify resistance factor to OV therapy in cancer cells using genome-wide CRISPR-Cas9 screens or compound library screen and genetically engineer novel OVs to unleash their oncolytic potential. These novel viruses will be tested as anticancer treatment agents in vitro in cancer cell lines, ex vivo in patient-derived cancer material and in vivo in murine and zebra fish models.
 

Your job responsibilities

As Postdoc immuno-onco-virology your position is primarily research-based but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues on your project, where you will receive supervision and guidance.

Your main tasks will consist of:

  • Independent research of high international quality, including publication.
  • Teaching and supervision of junior lab members.
  • Training in writing small grant applications

You will report to Associate Professor David Olagnier
 

Your competences

You have academic qualifications at PhD level, preferably within one or more of the following areas: molecular medicine, molecular biology, biochemistry, immunology, virology; and with a strong interest in cancer immunology and novel therapeutic options. Applicants with documented experience in animal models in vivo or with genome wide CRISPR-screens will be preferred.

You should be enthusiastic, motivated, result-driven and creative minded, with good organization, writing and communication skills. You should be interested in fundamental and translational research questions and be able to work both independently and in a team environment.

As a person, you are ambitious, take ownership and possess good communication and interpersonal skills. We expect you to be fluent in oral and written English.

In order to be assessed as qualified for a Postdoc position, you must meet these academic criteria.

Shortlisting will be used
 

Questions about the position

If you have any questions about the position, please contact David Olagnier; olagnier@biomed.au.dk

Your place of work will be the Department of Biomedicine, SKOU bygning, DK-8000 Aarhus C, Denmark.

We expect to conduct interviews in August and September 2022.
 



Terms of employment





Application


Your application must include the following:
  • Motivated application
  • Curriculum Vitae
  • Diploma
  • Template for applicant - postdoc must be completed and uploaded under ‘Extra documents’
  • A list of publications
  • A teaching portfolio. We refer to Guideline on the use of teaching portfolios
  • A maximum of five of the publications of greatest relevance to the job may be submitted (optional)
  • Strategic research plan can be uploaded (optional)
  • Coauthor statement(s) can be uploaded (optional)
  • References/recommendations can be uploaded separately in the e-recruitment system (optional)
We refer to the faculty’s Guidelines for applicants.

The assessment committee may decide to include non-submitted material in its statement. In such cases, you will be informed and obliged to submit material, unless your application is withdrawn.

Aarhus University’s ambition is to be an attractive and inspiring workplace for all and to foster a culture in which each individual has opportunities to thrive, achieve and develop. We view equality and diversity as assets, and we welcome all applicants.
 

Letter of reference

If you want a referee to upload a letter of reference on your behalf, please state the referee’s contact information when you submit your application. We strongly recommend that you make an agreement with the person in question before you enter the referee’s contact information, and that you ensure that the referee has enough time to write the letter of reference before the application deadline.
Unfortunately, it is not possible to ensure that letters of reference received after the application deadline will be taken into consideration.


International applicant?


Aarhus University offers a broad variety of services for international researchers and accompanying families, including relocation service and career counselling to expat partners. Please find more information about entering and working in Denmark here. Aarhus University also has a Junior Researcher Development Programme. You can read more about it here.

The application must be submitted via Aarhus University’s recruitment system, which can be accessed under the job advertisement on Aarhus University's website.

 
Aarhus University
Aarhus University is an academically diverse and research-intensive university with a strong commitment to high-quality research and education and the development of society nationally and globally. The university offers an inspiring research and teaching environment to its 38,000 students (FTEs) and 8,000 employees, and has an annual revenues of EUR 885 million. Learn more at www.international.au.dk/

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Andre job der minder om dette

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26. april 2022

PhD scholarship in Optimal Dynamic Operation of Po...

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DTU Kemiteknik onsdag 11 maj 22 Send ansøgning Frist 25. maj 2022 As our new PhD student, you will conduct research with focus on optimizing operations of novel power to ammonia processes and facilities. You will focus on achieving reliable, stable ...
10. maj 2022

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