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Postdoc in Immunology

Post-doctoral position in Immunology starting May 1 2021 available at the Technical University of Denmark (DTU), Department of Health Technology, Section of Experimental and Translational Immunology.

Research Project
The project is titled: The developmental requirements of a new intestinal T cell population.

Interleukin(IL)-17-producing lymphocytes are necessary anti-microbial immune cells against fungi and extracellular bacteria. At the same time, they play a major pathogenic role in chronic inflammation and autoimmunity. Therefore, detailed understanding of their biology can unravel new mechanisms of infectious and inflammatory diseases.

We discovered that a novel IL-17-producing, gut-specific T cell of the gamma delta (?d) lineage, which, unlike other subsets, co-produces the cytokine interferon(IFN)-? and develops within the first week of neonatal life (see Kadekar et al, 2020, J Clin Invest; ). We have confirmed the presence of such intestinal ?dT17 cells in human gut, and showed that they are a transcriptionally unique population, expressing genes not previously associated with ?d T cells (unpublished data).

In this project we aim to determine some of the key mechanisms that regulate the development of intestinal ?dT17 cells. In this regard, we have designed experiments that will answer: 1) whether intestinal ?dT17 cells derive from the thymus or are generated de novo in the gut, 2) whether they strictly require a neonatal microenvironment to develop, 3) when does their progenitor enter the gut, 4) whether the T cell receptor is important for their development and maintenance.

Research group and environment
The project will be carried out in the group of Dr. Vasileios Bekiaris.

At the Department of Health Technology, we have generated a vibrant and very productive research environment in Immunology, with all the required facilities and expertise in most areas of Immunology.

Qualifications

Education
Candidates should hold a PhD in Immunology or relevant discipline.

Research Skills & Expectations
The successful candidate must have demonstrable evidence in:

  • multi-parametric flow cytometry
  • mouse experimentation ( FELASA B training or country equivalent is necessary )
  • isolation of lymphocytes from primary mouse intestine and/or experience with lymphocyte isolation from embryonic and neonatal mouse tissues
  • basic biochemistry and molecular biology

  • Basic skills in R would be a great advantage.

    The successful candidate will be able to perform daily experiments with little supervision, contribute to other research activities in the group, participate actively in meetings and seminars and supervise MSc students.

    Personal Skills
    We are looking for a post-doc that functions well in a team environment, holds collegial respect to a high standard, is highly motivated and hardworking, and has research excellence as a top priority. Proficient skills in English is necessary.

    Assessment & approval
    Assessment of applications will be made by Dr. Vasileios Bekiaris.

    Salary and appointment terms
    The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 2 years.

    You can read more about
    Further information
    Further information may be obtained from Dr. Vasileios Bekiaris, />
    If you are applying from abroad, you may find useful information on working in Denmark and at DTU at


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