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Postdoc in molecular mechanisms of aging and neurodegeneration with special focus on DNA damage, mitochondrial stress, and inflammation

Department of Cellular and Molecular Medicine
Faculty of Health and Medical Sciences
University of Copenhagen




We are looking for a highly motivated and dynamic researcher for a three-year position to commence 1. September 2020.

You are eager to study the signalling pathways that connect normal aging process to age-related neurological diseases. You will investigate candidate pathways in human cells and in materials from various laboratory animal models in collaboration with other members of the group and our external collaboration partner.

Information on the department can be found at: https://icmm.ku.dk

Our research
The overall focus of our research is on understanding the mechanisms that control age-associated decline in brain function and neurodegenerative disorders. Particularly, our research is based on a working model that nuclear and mitochondrial DNA damage and altered mitochondrial homeostasis generate signalling pathways that drive the aging process as well as the development and progression of associated diseases, especially neurodegenerative disorders.

In our work, we use different animal models and human cells in close collaboration with Danish research laboratories and international research institutes including INSERM France, Newcastle University UK, University of Oslo, and National Institute on Aging, NIH, USA, with a broad range of expertise from cell biology to bioinformatics and computer modelling of complicated biological systems. This broad collaboration network has resulted in the publication of several scientific papers in quality journals in recent years.

You can find out more about our lab here: https://icmm.ku.dk/english/research-groups/akbaribohr-group/

Your job
We are currently focused on various inflammatory responses as key signalling pathways connecting DNA damage, altered mitochondrial homeostasis, and cellular stress to neurodegeneration, which is also the focus of this project. You will be working on your own project(s) and you will be involved in projects we carry out in collaboration with our international partners.

Profile
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:

Essential experience and skills:

  • You have a PhD in molecular biology and biomedical sciences.
  • You are highly experienced in cell culturing, DNA, RNA, and protein analysis techniques.
  • You have an active interest in the biology of aging and age-associated neurodegenerative diseases
  • Proficient communication skills and ability to work in teams
  • Excellent English skills written and spoken
Desirable experience and skills:

  • Knowledge and experience in mitochondrial biology, confocal microscopy, immunofluorescence, flow cytometry.
  • Experience in handling C.elegans and/or mice.
  • Experience in handling mouse brain tissue and primary neuronal culture.
  • Experience/knowledge in microarray and RNA-sequencing data analysis.
Place of employment
The place of employment is at Department of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Our research facilities include modern laboratories, offices and meeting rooms in the Maersk Tower.

Terms of employment
The employment as postdoc is a full time and fixed-term position for three years. Starting date is 1 September 2020 or after agreement.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 34,400 DKK/ approx. 4,610 Euro (April 2020-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of 11 December 2019.

Questions
For further information please contact Professor Vilhelm A. Bohr; vbohr@sund.ku.dk.

Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).

Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore your application must include the following documents/attachments – all in PDF format:

  1. Motivated letter of application (max. one page).
  2. CV incl. education, work/research experience, language skills and other skills relevant for the position.
  3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
  4. List of publications.
Application deadline: 6 July, 2020, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

Interviews are expected to be held in weeks 32-33.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.




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