Postdoc Position in Biomarker Discovery and Clinical Proteomics

Title: Development of a semi-automated biomarker discovery platform for clinical proteomics.

Background: 
Quantitative proteomics technologies hold a great potential to discover, validate and accurately quantify protein disease biomarkers in body fluids and primary tissues. However, cell dynamics and survival are highly linked with cellular signalling pathways that are regulated and controlled by post-translational modifications (PTMs) of proteins. In fact, about 5% of all proteins in the cell are enzymes capable of modulating the more than 400 known PTMs found in human cells. 

Since most diseases are developed due to perturbation in cellular signalling pathways, it is reasonable to believe that alterations in PTMs would have a much greater disease biomarker potential than alteration in protein expression in general.
The purpose of the project is to develop a robust quantitative proteomics platform for the identification and validation of selected PTMs of proteins that can be used to confidently identify biomarkers in clinical proteomics for the diagnosis of the disease, the stratification of patients according to their disease endotype or to monitor therapeutic responses to specific treatments in individual patients, personalized medicine.

Deadline: 15 August 2019.

Please see the full call, including how to apply, on www.sdu.dk.


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330048359Phoenix-4f35997412019-06-24T00:00:00Postdoc Position in Biomarker Discovery and Clinical Proteomics

Title: Development of a semi-automated biomarker discovery platform for clinical proteomics.

Background: 
Quantitative proteomics technologies hold a great potential to discover, validate and accurately quantify protein disease biomarkers in body fluids and primary tissues. However, cell dynamics and survival are highly linked with cellular signalling pathways that are regulated and controlled by post-translational modifications (PTMs) of proteins. In fact, about 5% of all proteins in the cell are enzymes capable of modulating the more than 400 known PTMs found in human cells. 

Since most diseases are developed due to perturbation in cellular signalling pathways, it is reasonable to believe that alterations in PTMs would have a much greater disease biomarker potential than alteration in protein expression in general.
The purpose of the project is to develop a robust quantitative proteomics platform for the identification and validation of selected PTMs of proteins that can be used to confidently identify biomarkers in clinical proteomics for the diagnosis of the disease, the stratification of patients according to their disease endotype or to monitor therapeutic responses to specific treatments in individual patients, personalized medicine.

Deadline: 15 August 2019.

Please see the full call, including how to apply, on www.sdu.dk.

Title: Development of a semi-automated biomarker discovery platform for clinical proteomics.Background: Quantitative proteomics technologies hold a great potential to discover, validate and accurately quantify protein disease biomarkers in body fluids and primary tissues. However, cell dynamics and survival are highly linked with cellular signalling pathways that are regulated and controlled by post-translational modifications (PTMs) of proteins. In fact, about 5 of all proteins in the cell are enzymes capable of modulating the more than 400 known PTMs found in human cells. Since most diseases are developed due to perturbation in cellular signalling pathways, it is reasonable to believe that alterations in PTMs would have a much greater disease biomarker potential than alteration in protein expression in general.The purpose of the project is to develop a robust quantitative proteomics platform for the identification and validation of selected PTMs of proteins that can be used to confidently identify biomarkers in clinical proteomics for the diagnosis of the disease, the stratification of patients according to their disease endotype or to monitor therapeutic responses to specific treatments in individual patients, personalized medicine.Deadline: 15 August 2019.Please see the full call, including how to apply, on www.sdu.dk.11jobnet4f359974100000000000aDK_OFIR_02DKDanmark228DKK2019-08-15T00:00:000000https://job.jobnet.dk/CV/FindJob/details/50089140EuropaDanmarkFyn & Sydfynske øerFynOdense3551732Syddansk Universitet11Campusvej 555230Odense MDKDanmark0
DKDanmarkDKDanmark
8Fuldtid47Tidsbegrænset782770JobNet5008914500891410024-06-20190https://dispatcher.ofir.dk/statistic/register?context=FeedEntrySearchedCount&feedId=dc2beb84&entryId=4f359974https://dispatcher.ofir.dk/statistic/register?context=FeedEntryDisplayCount&feedId=dc2beb84&entryId=4f359974https://dispatcher.ofir.dk/statistic/register?context=JobApplicationInitiatedCount&feedId=dc2beb84&entryId=4f359974&page=ShowJob&component=SendApplicationButtonhttps://dispatcher.ofir.dk/statistic/register?context=JobApplicationAppliedCount&feedId=dc2beb84&entryId=4f359974&page=EmailApplyForm&component=SendApplicationButtonhttps://static.matchwork.com/company/logo/DK/ORS/SoMe/Produktion_haandvaerk_og_transport/Haandvaerk_og_service/12.jpgEr du en fagligt stærk General?12007991Dansk3Læse/ tale11007General7Håndværk & service362122347noreply@ofir.comDKDanmarkDKDanmark330037448PhD Position in Adipocyte Signalling Using Advanced Functional GenomicsRobot The Center for Adipocyte Signaling ADIPOSIGN at the Functional Genomics Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, invites applications from outstanding candidates who are interested in joining our team as a PhD student. The PhD student will be affiliated with the Kornfeld Group. The position is available from 1 October 2019 or as soon as possible thereafter. ADIPOSIGN ADIPOSIGN is a new centre established for a six-year period through a major grant from the Novo Nordisk Foundation. We combine experimental and computational systems approaches to obtain unprecedented insights into how fat cells receive and respond to signals at the level of the (epi)-genome and the cell membrane. Our goal is to understand how the signalling states of adipocytes depend on depot, gender and genetic variation, and how changes in these signalling states during development of obesity contribute to the pathophysiological consequences of obesity. Deadline: 30 July 2019. Please see the full call, including how to apply, on www.sdu.dk.

The Center for Adipocyte Signaling – ADIPOSIGN at the Functional Genomics & Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, invites applications from outstanding candidates who are interested in joining our team as a PhD student. The PhD student will be affiliated with the Kornfeld Group. The position is available from 1 October 2019 or as soon as possible thereafter. 

ADIPOSIGN
ADIPOSIGN is a new centre established for a six-year period through a major grant from the Novo Nordisk Foundation. We combine experimental and computational systems approaches to obtain unprecedented insights into how fat cells receive and respond to signals at the level of the (epi)-genome and the cell membrane. Our goal is to understand how the signalling states of adipocytes depend on depot, gender and genetic variation, and how changes in these signalling states during development of obesity contribute to the pathophysiological consequences of obesity.

Deadline: 30 July 2019.

Please see the full call, including how to apply, on www.sdu.dk.

Syddansk UniversitetOdense M2019-06-04T00:00:002019-07-30T00:00:00
da-DK

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PhD Position in Adipocyte Signalling Using Advanced Functional Genomics

Syddansk Universitet

Odense M
The Center for Adipocyte Signaling ADIPOSIGN at the Functional Genomics Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, invites applications from outstanding candidates who are interested i...
Indrykket:4. juni 2019
Udløbsdato:30. juli 2019