Postdoc Position in RNA Biology and Adipose Metabolism

Center for Physical Activity Research Rigshospitalet, University of Copenhagen We are looking for a postdoc with a passion for science and experience in RNA biology and/or organelle communication to start January 4th, 2021 or according to agreement.

Background

The Center for Physical Activity Research (CFAS) is a translational research institution located at Rigshospitalet (University Hospital of Copenhagen). Our vision is to develop targeted strategies for specific disease groups by applying the unconventional strategy “from man to molecule and back”.

The available postdoc position is within the Nielsen Group. The primary research focus in our group is to study how long non-coding RNAs (lncRNAs) control metabolism in brown and white adipose tissue, and how this class of RNAs can be relocated upon adipocyte activation. You can read more about the research of the Nielsen group at www.nielsen-RNAgroup.com.

The Nielsen Group is part of CFAS, which comprises several research groups performing advanced human intervention studies. We work in close collaboration with these in vivo groups and isolate primary brown and white adipocytes from a wide range of human donors. The multi-disciplinary structure of CFAS uniquely allows us to identify biological processes in vitro, and then examine the physiological relevance in a human in vivo setup. A key principle in CFAS is that the research carried out in the laboratories can find direct application in human settings.

Project Description

The candidate will be involved in several projects with the overall goal of depicting the acute metabolic roles of non-coding RNAs in brown and white adipocytes. Recently, we identified a novel lncRNA in human brown adipocytes. We showed that the lncRNA plays a major role as a metabolic enhancer in brown adipocytes targeting two cytosolic organelles (Nature Metabolism, 2020). Our next step will be to develop a spatial RNA map in human adipocytes showing the cytosolic locations of lncRNAs upon a metabolic stimulus. Based on the cellular location, we will identify target organelles and decipher how the interaction affects adipocyte biology using CRISPR based technologies. We will furthermore examine if specific lncRNA structures determine their cellular localization. A secondary aim is to implement the knowledge generated in the adipocytes to other metabolic cell types such as myocytes and hepatocytes.

Profile

The candidate should possess an eagerness to tackle advanced scientific obstacles. Thus, we are looking for a highly motivated and enthusiastic scientist ideally combining some or all of the following competences and qualifications:

  • An educational background in e.g. molecular biology and a PhD degree
  • A strong CV with a solid publication track record and participation in international meetings
  • Creative, open-minded, and eager to learn new methods
  • Experience with RNA biology; preferably noncoding RNAs
  • Experience with fluorescence imaging techniques, including FISH
  • Skilled within adherent cell cultures and related functional assays
  • Knowledge within CRISPR-based technologies
  • Knowledge about adipocyte biology is an advantage but not a requirement
  • Ability to contribute ideas for new research projects and to supervise students
  • Excellent English communication skills, both written and oral
We Offer

  • To be part of a group with high ambitions and a strong international network
  • A position where you will be the main driver of a project in the context of a supportive and interactive group and group leader
  • A fully funded, two-year postdoctoral fellowship including pension
  • A center of skilled and dedicated interdisciplinary colleagues, and a great social environment
  • In-house, free gym facilities
Terms of Employment

The successful candidate will be employed as postdoctoral fellow at Rigshospitalet, Region Hovedstaden (Capital Region of Denmark). Based on background education and seniority, your salary, pension and terms of employment will be settled in accordance with the existing agreement between the Danish Regions (Danske Regioner) and the relevant professional organization. No salary negotiation can be expected beyond these terms.

Questions

For further information about the position, please contact Group Leader Søren Nielsen at soeren.nielsen.01@regionh.dk. For questions regarding the recruitment procedure, please contact CFAS Administrator Inge Holm at inge.holm@regionh.dk.

Application procedure

Please upload your application in English, describing your background and research interests. Please enclose CV (maximum of 2 pages; your ORCID must be included) publication list, documentation of relevant education and contact information of 1-3 scientific references.

Application deadline: December 1stth, 2020, 23.59pm CET

We reserve the right to neither consider material received after the deadline, nor applications that do not meet the above-mentioned requirements.


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