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Postdoc position in Structural Biology of Mitochondrial DNA Replication at Novo Nordisk Foundation Center for Protein Research

Faculty of Health and Medical Sciences
University of Copenhagen


The Kummer lab is recruiting an excellent and highly motivated postdoctoral candidate to investigate how mitochondria maintain their genome. The position is available from 14 June 2021 or as soon as possible thereafter. Place of work will be the Novo Nordisk Center for Protein Research (NNF-CPR), Faculty of Health and Medical Sciences, University Copenhagen, which is located in central Copenhagen. www.cpr.ku.dk/.

Project Description
Our lab has a deep interest to understand mitochondrial biology on a structural and functional level with a specific focus on how mitochondria maintain their DNA and how they produce functional RNA species. In this framework, the candidate will investigate membrane protein complexes relevant for proper distribution of mitochondrial DNA in the mitochondrial network. The primary methodological focus will be on single particle cryo-EM with the option for implementing cryo-electron tomography to correlate molecular findings with cellular phenotypes.

Required qualifications
A strong background in protein biochemistry (preferentially of membrane proteins) and cryo-electron microscopy or crystallography is required. The candidate is joining a newly established lab and strong team player and networking skills are therefore valued. As a Postdoctoral candidate, you will have the opportunity to work on an interesting and challenging project that will profit from your enthusiasm, creativity and willingness to implement new methodology.

Qualifications that are assessed during the selection process are:

  • PhD in Biology, Biochemistry, Biophysics or related fields
  • Expertise in protein expression in human cell lines
  • Expertise in purification of (preferentially membrane) protein assemblies
  • Expertise in data analysis and structure building in single particle cryo-EM/crystallography or related expertise in cryo-electron tomography
  • Interest and experience in supervising BSc and MSc students
  • Publications in high-quality journals and presentations at international conferences
  • Ability to manage a research project and the associated resources
Questions?
For informal inquiries please contact the principal investigator via eva.kummer@cpr.ku.dk.

About the CPR
The Novo Nordisk Center for Protein Research (NNF-CPR) was established in 2007 at the Faculty of Health and Medical Sciences, University of Copenhagen, to promote basic and applied research.
https://www.cpr.ku.dk/.

The Kummer group (https://www.cpr.ku.dk/research/protein-structure-function-program/kummer/) is part of the Protein Structure and Function Program at NNF-CPR that contains the groups of Guillermo Montoya (Program Director) and Nicholas Taylor. The Program provides state-of-the-art infrastructure and instrumentation including a Titan Krios and a Glacios both equipped with Falcon III DED, as well as multiple smaller screening instruments. In addition, the center entertains a number of core facilities including protein production, crystallography, biophysics, high performance computing, mass spectrometry, and genomics. Besides joining an interdisciplinary, collaborative and supportive environment, the selected candidate can also profit from soft skill courses run by the CPR or the University of Copenhagen.

The CPR is located in the beautiful city of Copenhagen and next to being part of a vibrant and supportive research environment, the candidate will be able to enjoy numerous cultural and culinary highlights throughout the year in one of the most livable cities in the world.

About the PI
Eva Kummer has strong expertise in protein and RNA biochemistry as well as electron microscopy. After a PhD in biochemistry on mechanisms of protein quality control in bacteria and yeast, her latest research has focused on unraveling mammalian mitochondrial translation mechanisms. For this, she has combined in vitro reconstitution approaches with single-particle cryo-EM. For further information on the PI, please visit:

https://www.linkedin.com/in/eva-kummer-7099931b7/
https://www.researchgate.net/profile/Eva-Kummer

Terms of salary and employment
Salary, pension, and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary is around 34.622,58 DKK approx. 4,656 €, (February 2021-level) plus 17.1 % in pension contribution. Depending on qualifications, a supplement may be negotiated.

The Danish Ministry of Finance and the Danish Confederation of Professional Associations (AC) have agreed on a protocol that makes it possible for all international researchers employed by the University to achieve a pension exemption, where the pension can be paid out as salary. For more information about the different pension schemes www.ism.ku.dk/onarrival/pension/

Duration: The duration of the position is 2 years with a possibility of extension (depending on the performance, and previous employment at the University of Copenhagen).

Application procedure
Your application must be submitted electronically by clicking ‘APPLY NOW’ below or via this advertisement found on http://employment.ku.dk/faculty/.
For questions on the application procedure, please contact sund-hr-cpr@sund.ku.dk.

Your application should include the following documents:

  • Cover letter describing your motivation and qualifications for the position
  • Curriculum vitae with contact details for at least three references
  • Complete publication list
  • Diplomas (Master and PhD degree or equivalent)
  • Separate reprints of 3 particularly relevant papers
The applicants can submit these materials in the given fields in the online submission system. We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the above-mentioned requirements and that do not have a least one publication as first author.

Deadline for application: April 11, 2021, 23:59 CET.

After the expiry of the application deadline, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at www.employment.ku.dk. For further information about the position or the process or if you experience any technical difficulty with the online submission system, please contact SUND HR: sund-hr-cpr@sund.ku.dk.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.


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