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Postdoc positions in Computational studies of protein stability, degradation and interactions

Two or more postdoctoral positions are available from Sept 1, 2019, or as soon as possible thereafter, in the PRISM centre, Department of Biology, Faculty of Science, University of Copenhagen, Denmark. The research within PRISM bridges protein biophysics and genomics using computational and experimental methods. The positions in this call are focused on computational and data analysis aspects of PRISM, and research areas include structural bioinformatics, molecular simulations, analysis of multiplexed-assays of variant effects and protein-sequence analyses. Separate calls are available for PhD positions as well as for postdoctoral positions for the wet-lab based part of PRISM.

About the centre and research environment

The positions are part of the newly established Centre called PRISM: Protein Interactions and Stability in Medicine and Genomics, funded via a six-year Novo Nordisk Foundation Challenge grant. The overarching hypothesis behind PRISM is that by combining the latest developments in structural biology, protein folding, high-throughput experiments, computational biophysics and genomics we may transform our current view of how genomic variation perturbs the stability, folding and function of proteins. In turn, we can use such information to understand, diagnose and ultimately treat human diseases. PRISM is a collaboration between three research groups at the Department of Biology, Copenhagen (led by Kresten Lindorff-Larsen, Amelie Stein, Rasmus Hartmann-Petersen), and Michele Vendruscolo (University of Cambridge, UK), Douglas M. Fowler (University of Washington, US) and Torben Hansen (Novo Nordisk Foundation centre for Basic Metabolic Research, DK).

The postdoctoral fellows will work in the groups of Kresten Lindorff-Larsen or Amelie Stein, both located in the Department of Biology in central Copenhagen. The two research groups are members of the highly interdisciplinary and collaborative research environment at the Linderstrøm-Lang Centre for Protein Science. The postdoctoral fellows will work together with scientists from a number of disciplines, and also have the possibility of spending time in one or more of the partner laboratories within PRISM. The groups are highly international and a good level of spoken and written English is required.

Details of the positions and research topics

The postdoctoral positions (2 years with the possibility of extension) will work on one or more of the subprojects within PRISM. Long-term goals include developing predictive and mechanistic models for how genomic variation in protein-coding regions (protein variants) affect the stability, interactions and function of proteins. For an introduction to the research see e.g. our recent review (Stein et al, TiBS, 2019, https://doi.org/10.1016/j.tibs.2019.01.003). Research topics for the positions include:

  • Predicting effects of variation on protein stability and protein-protein interactions
  • Linking multiplexed/deep mutational scanning experiments to biophysical calculations and molecular simulations
  • Studying the mechanistic and biophysical aspects of cellular protein stability and degradation
  • Development and application of prediction methods to interpret genomic variation
As PRISM develops we expect the candidates to also develop their own research ideas within the context of the project.

Qualifications

We are seeking motivated and strong applicants with a PhD degree in biophysics, bioinformatics, physics, chemistry or biochemistry or similar fields with documented prior research experience within one or more of these areas:

  • Structural bioinformatics
  • Molecular simulations of protein folding and stability
  • Computational analyses of the effects of protein sequence variation on protein stability, interactions and function
  • Bioinformatics analysis linking genomic sequences to protein properties of protein structure
  • Computational analyses of deep mutational scanning experiments
  • Computational analyses of disease-causing protein coding variants
It will also be advantageous to have experience with one or more of the following:

  • The Rosetta software for protein structure modelling
  • Large-scale homology modelling
  • Machine learning applications to protein structure or protein sequences
  • Mathematical modelling of protein homeostasis
For further information about the positions, please contact Professor Kresten Lindorff-Larsen (lindorff@bio.ku.dk) or Assistant Professor Amelie Stein (amelie.stein@bio.ku.dk). Further information about the Department may be found at https://www1.bio.ku.dk/english/

The position is open from 1st Sept 2019 or as soon as possible thereafter.

The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

Terms of employment

The position is covered by the Memorandum on Job Structure for Academic Staff.

Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.

The starting salary is currently up to DKK 430.569 including annual supplement (+ pension up to DKK 73.627). Negotiation for salary supplement is possible.

The application, in English, must be submitted electronically by clicking APPLY NOW below.

Please include

  • A cover letter (max 1. page) explaining your background, key skills and how they are relevant to the research in PRISM, and your motivation for applying
  • Curriculum vitae (max 2. pages) including educational background previous research experience
  • List of publications (including preprints and papers in review)
  • PhD diploma including any written evaluation if applicable. If you are expecting to defend your PhD before September 1st and would like to apply, please submit a letter from your supervisor regarding your expected defence date
  • Contact details for two former employers or supervisors (no reference letters should be attached)
The deadline for applications is 19th July 2019 23:59 GMT +2.

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/.

Interviews will be held during August


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330046389Phoenix-20aafbff12019-06-19T00:00:00Postdoc positions in Computational studies of protein stability, degradation and interactionsTwo or more postdoctoral positions are available from Sept 1, 2019, or as soon as possible thereafter, in the PRISM centre, Department of Biology, Faculty of Science, University of Copenhagen, Denmark. The research within PRISM bridges protein biophysics and genomics using computational and experimental methods. The positions in this call are focused on computational and data analysis aspects of PRISM, and research areas include structural bioinformatics, molecular simulations, analysis of multiplexed-assays of variant effects and protein-sequence analyses. Separate calls are available for PhD positions as well as for postdoctoral positions for the wet-lab based part of PRISM.

About the centre and research environment

The positions are part of the newly established Centre called PRISM: Protein Interactions and Stability in Medicine and Genomics, funded via a six-year Novo Nordisk Foundation Challenge grant. The overarching hypothesis behind PRISM is that by combining the latest developments in structural biology, protein folding, high-throughput experiments, computational biophysics and genomics we may transform our current view of how genomic variation perturbs the stability, folding and function of proteins. In turn, we can use such information to understand, diagnose and ultimately treat human diseases. PRISM is a collaboration between three research groups at the Department of Biology, Copenhagen (led by Kresten Lindorff-Larsen, Amelie Stein, Rasmus Hartmann-Petersen), and Michele Vendruscolo (University of Cambridge, UK), Douglas M. Fowler (University of Washington, US) and Torben Hansen (Novo Nordisk Foundation centre for Basic Metabolic Research, DK).

The postdoctoral fellows will work in the groups of Kresten Lindorff-Larsen or Amelie Stein, both located in the Department of Biology in central Copenhagen. The two research groups are members of the highly interdisciplinary and collaborative research environment at the Linderstrøm-Lang Centre for Protein Science. The postdoctoral fellows will work together with scientists from a number of disciplines, and also have the possibility of spending time in one or more of the partner laboratories within PRISM. The groups are highly international and a good level of spoken and written English is required.

Details of the positions and research topics

The postdoctoral positions (2 years with the possibility of extension) will work on one or more of the subprojects within PRISM. Long-term goals include developing predictive and mechanistic models for how genomic variation in protein-coding regions (protein variants) affect the stability, interactions and function of proteins. For an introduction to the research see e.g. our recent review (Stein et al, TiBS, 2019, https://doi.org/10.1016/j.tibs.2019.01.003). Research topics for the positions include:

  • Predicting effects of variation on protein stability and protein-protein interactions
  • Linking multiplexed/deep mutational scanning experiments to biophysical calculations and molecular simulations
  • Studying the mechanistic and biophysical aspects of cellular protein stability and degradation
  • Development and application of prediction methods to interpret genomic variation
As PRISM develops we expect the candidates to also develop their own research ideas within the context of the project.

Qualifications

We are seeking motivated and strong applicants with a PhD degree in biophysics, bioinformatics, physics, chemistry or biochemistry or similar fields with documented prior research experience within one or more of these areas:

  • Structural bioinformatics
  • Molecular simulations of protein folding and stability
  • Computational analyses of the effects of protein sequence variation on protein stability, interactions and function
  • Bioinformatics analysis linking genomic sequences to protein properties of protein structure
  • Computational analyses of deep mutational scanning experiments
  • Computational analyses of disease-causing protein coding variants
It will also be advantageous to have experience with one or more of the following:

  • The Rosetta software for protein structure modelling
  • Large-scale homology modelling
  • Machine learning applications to protein structure or protein sequences
  • Mathematical modelling of protein homeostasis
For further information about the positions, please contact Professor Kresten Lindorff-Larsen (lindorff@bio.ku.dk) or Assistant Professor Amelie Stein (amelie.stein@bio.ku.dk). Further information about the Department may be found at https://www1.bio.ku.dk/english/

The position is open from 1st Sept 2019 or as soon as possible thereafter.

The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

Terms of employment

The position is covered by the Memorandum on Job Structure for Academic Staff.

Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.

The starting salary is currently up to DKK 430.569 including annual supplement (+ pension up to DKK 73.627). Negotiation for salary supplement is possible.

The application, in English, must be submitted electronically by clicking APPLY NOW below.

Please include

  • A cover letter (max 1. page) explaining your background, key skills and how they are relevant to the research in PRISM, and your motivation for applying
  • Curriculum vitae (max 2. pages) including educational background previous research experience
  • List of publications (including preprints and papers in review)
  • PhD diploma including any written evaluation if applicable. If you are expecting to defend your PhD before September 1st and would like to apply, please submit a letter from your supervisor regarding your expected defence date
  • Contact details for two former employers or supervisors (no reference letters should be attached)
The deadline for applications is 19th July 2019 23:59 GMT +2.

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/.

Interviews will be held during August

2019-07-20T00:51:11.700 Two or more postdoctoral positions are available from Sept 1, 2019, or as soon as possible thereafter, in the PRISM centre, Department of Biology, Faculty of Science, University of Copenhagen, Denmark. The research within PRISM bridges protein biophysics and genomics using computational and experimental methods. The positions in this call are focused on computational and data analysis aspects of PRISM, and research areas include structural bioinformatics, molecular simulations, analysis of multiplexed-assays of variant effects and protein-sequence analyses. Separate calls are available for PhD positions as well as for postdoctoral positions for the wet-lab based part of PRISM. About the centre and research environment The positions are part of the newly established Centre called PRISM: Protein Interactions and Stability in Medicine and Genomics, funded via a six-year Novo Nordisk Foundation Challenge grant. The overarching hypothesis behind PRISM is that by combining the latest developments in structural biology, protein folding, high-throughput experiments, computational biophysics and genomics we may transform our current view of how genomic variation perturbs the stability, folding and function of proteins. In turn, we can use such information to understand, diagnose and ultimately treat human diseases. PRISM is a collaboration between three research groups at the Department of Biology, Copenhagen (led by Kresten Lindorff-Larsen, Amelie Stein, Rasmus Hartmann-Petersen), and Michele Vendruscolo (University of Cambridge, UK), Douglas M. Fowler (University of Washington, US) and Torben Hansen (Novo Nordisk Foundation centre for Basic Metabolic Research, DK). The postdoctoral fellows will work in the groups of Kresten Lindorff-Larsen or Amelie Stein, both located in the Department of Biology in central Copenhagen. The two research groups are members of the highly interdisciplinary and collaborative research environment at the Linderstrøm-Lang Centre for Protein Science. The postdoctoral fellows will work together with scientists from a number of disciplines, and also have the possibility of spending time in one or more of the partner laboratories within PRISM. The groups are highly international and a good level of spoken and written English is required. Details of the positions and research topics The postdoctoral positions (2 years with the possibility of extension) will work on one or more of the subprojects within PRISM. Long-term goals include developing predictive and mechanistic models for how genomic variation in protein-coding regions (protein variants) affect the stability, interactions and function of proteins. For an introduction to the research see e.g. our recent review (Stein et al, TiBS, 2019, https: doi.org 10.1016 j.tibs.2019.01.003). Research topics for the positions include: Predicting effects of variation on protein stability and protein-protein interactions Linking multiplexed deep mutational scanning experiments to biophysical calculations and molecular simulations Studying the mechanistic and biophysical aspects of cellular protein stability and degradation Development and application of prediction methods to interpret genomic variation As PRISM develops we expect the candidates to also develop their own research ideas within the context of the project. Qualifications We are seeking motivated and strong applicants with a PhD degree in biophysics, bioinformatics, physics, chemistry or biochemistry or similar fields with documented prior research experience within one or more of these areas: Structural bioinformatics Molecular simulations of protein folding and stability Computational analyses of the effects of protein sequence variation on protein stability, interactions and function Bioinformatics analysis linking genomic sequences to protein properties of protein structure Computational analyses of deep mutational scanning experiments Computational analyses of disease-causing protein coding variants It will also be advantageous to have experience with one or more of the following: The Rosetta software for protein structure modelling Large-scale homology modelling Machine learning applications to protein structure or protein sequences Mathematical modelling of protein homeostasis For further information about the positions, please contact Professor Kresten Lindorff-Larsen (lindorff@bio.ku.dk) or Assistant Professor Amelie Stein (amelie.stein@bio.ku.dk). Further information about the Department may be found at https: www1.bio.ku.dk english The position is open from 1st Sept 2019 or as soon as possible thereafter. The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background. Terms of employment The position is covered by the Memorandum on Job Structure for Academic Staff. Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. The starting salary is currently up to DKK 430.569 including annual supplement ( pension up to DKK 73.627). Negotiation for salary supplement is possible. The application, in English, must be submitted electronically by clicking APPLY NOW below. Please include A cover letter (max 1. page) explaining your background, key skills and how they are relevant to the research in PRISM, and your motivation for applying Curriculum vitae (max 2. pages) including educational background previous research experience List of publications (including preprints and papers in review) PhD diploma including any written evaluation if applicable. If you are expecting to defend your PhD before September 1st and would like to apply, please submit a letter from your supervisor regarding your expected defence date Contact details for two former employers or supervisors (no reference letters should be attached) The deadline for applications is 19th July 2019 23:59 GMT 2. After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. You can read about the recruitment process at http: employment.ku.dk faculty recruitment-process . Interviews will be held during August11jobnet20aafbff100000000000IDK_OFIR_02DKDanmark228DKK2019-07-19T00:00:000000https://candidate.hr-manager.net/ApplicationInit.aspx?cid=1307&ProjectId=149772&DepartmentId=18965&MediaId=4632&SkipAdvertisement=true0EuropaDanmarkSjælland & øerNordsjællandHelsingør3549949KU SCIENCE BIO11Marinebiologisk Laboratorium, Strandpromenaden 53000HelsingørDKDanmark0DKDanmarkDKDanmark8Fuldtid47Tidsbegrænset781058JobNet5007453500745310019-06-20190https://dispatcher.ofir.dk/statistic/register?context=FeedEntrySearchedCount&feedId=dc2beb84&entryId=20aafbffhttps://dispatcher.ofir.dk/statistic/register?context=FeedEntryDisplayCount&feedId=dc2beb84&entryId=20aafbffhttps://dispatcher.ofir.dk/statistic/register?context=JobApplicationInitiatedCount&feedId=dc2beb84&entryId=20aafbff&page=ShowJob&component=SendApplicationButtonhttps://dispatcher.ofir.dk/statistic/register?context=JobApplicationAppliedCount&feedId=dc2beb84&entryId=20aafbff&page=EmailApplyForm&component=SendApplicationButtonPostdoc positions in Computational studies of protein stability, degradation and interactions1Dansk3Læse/ tale343927Supervisor6Ledelse362110480lindorff@bio.ku.dkDKDanmarkDKDanmarkda-DK