Postdoctoral Fellow in Integrative Physiology

Background
The Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) has been established at the Faculty of Health Sciences, University of Copenhagen to conduct fundamental research on metabolism (http://cbmr.ku.dk/). The center, which consists of five scientific sections and a number of international research satellites, was established through an unrestricted grant from the Novo Nordisk Foundation. The current position is in the Section of Integrative Physiology, headed by Professor Juleen Zierath.

Project Description
The overall aim is to determine the interaction between circadian rhythms and the metabolic response to exercise to define potent interventional strategies that can prevent insulin resistance and T2D. The successful candidate will work in a scientific environment that bridges several disciplines and complementary expertise in clinical medicine, exercise physiology, circadian rhythms, metabolism and gene regulation to ensure development of innovative strategies to improve metabolic health through exercise and nutrient interventions in people at risk or diagnosed with T2D.

The aim of project is to determine the genomic response to factors impairing or ameliorating insulin sensitivity, under various circadian states. Cell system-based screening will be used to identify nutrient-contraction interactions on insulin sensitivity. Transcriptomic and epigenetic profiles in the various states of insulin-sensitivity will be assessed using RNA-Seq, whole genome DNA methylation, Chromatin Immunoprecipitation (ChIP)-Seq using histone marks of active and repressive chromatin states, as well as marks associated with active enhancer activity. Transcriptomic and epigenetic signatures will be computationally integrated to determine the genomic responses to contraction.

Selection criteria

  • PhD in Biology, Biochemistry, Molecular Biology or related sciences.
  • Experience in chromatin immunoprecipitation, DNA methylation analyses (Bisulfite Sequencing, Reduced Representation Bisulfite Sequencing) and gene expression analyses (quantitative PCR, RNA-Seq or gene expression arrays).
  • Excellent computing skills and Experience in handling deep sequencing or genome-wide data.
  • Extensive experience in tissue or cell culture, preferably muscle cell and adipocyte culture.
  • Background knowledge in epigenetics and cell metabolism.
  • Track record in molecular biology, cell biology or regulation of transcription.
  • Excellent written and oral communication skills.
  • Demonstrated capacity for effective teamwork.
Relationships
The holder of the position will report to the Director of the Integrative Physiology Section (Prof. Juleen Zierath) and the Deputy Director (A/Prof. Romain Barrès).
The holder of the position is expected to interact with staff at all levels, both internally and externally, regarding relevant research topics.

Employment Conditions
Employment will be as postdoctoral Fellow a time-limited 2-year project. Employment will be in accordance with the provisions of the collective agreement between the Danish Government and AC (the Danish Confederation of Professional Associations). The gross basic salary range for Postdoctoral Fellows is DKK 33,224 to DKK 37,980 per month (level 6 to 8). To the basic salary a supplement may be negotiated, dependent on the candidate’s experience and qualifications. An additional 17.1% monthly contribution to pension will be paid by the employer.

The starting date is 1st of June 2018 or as soon as possible thereafter.

Questions
For further information, please contact Associate Professor Romain Barrès, barres@sund.ku.dk.
For administrative questions, please write to sund-hr-cbmr@sund.ku.dk.

Application
The application must be submitted on-line and in English, by clicking on “Apply online”. The following documents should be included:
  • Letter of motivation addressing all the essential criteria (max 2 pages)
  • CV without list of publications.
  • Complete list of publications (only published or accepted publications in peer reviewed journals).
The deadline for applications is 30 April 2018 at 23:59 CET

Any applications received after this time will not be considered.

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are immediately notified whether their application has been passed for assessment by an Expert Assessment Committee. Selected applicants will be notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him-/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of personal background.



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