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Postdoctoral Fellowship in Computational Chemistry

Postdoctoral Fellowship in Computational Chemistry, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen. 
 
Background:
The Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) has been established at the Faculty of Health Sciences, University of Copenhagen to conduct basic research on metabolism (www.metabol.ku.dk) based on a DKK 885 million unrestricted grant from the Novo Nordisk Foundation. We are a center of excellence where talented researchers and experienced laboratory technicians is bringing scientific discoveries from the laboratory to the society in an effort to tackle some of today’s biggest challenges – diabetes and obesity. We are proud of the outstanding discoveries made by the Center, and we are committed to the translation of this knowledge into novel approaches to patient care. The position is in the Group of Associate Professor Thomas Frimurer in Section for Metabolic Receptology headed by Thue W. Schwartz.  
 
Position and project description:
A 2-year postdoctoral fellowship is available at the Computational Chemistry Group of Thomas Frimurer. The candidate will develop and apply recent advancements in computational chemistry and structure-based design to discover in particular small molecule ligands to be used as pharmacological tool compounds and early drug leads. These ligands will enable evaluation of the physiological role and the pharmacological potential of proteins and receptors related to metabolic disorders. The work will be performed in close collaboration with the molecular pharmacology group, which the team is closely integrated with physically.  
 
Qualifications and requirements: 
Ph.D. with an excellent track record from a leading laboratory in the fields of computational chemistry. Excellent written and oral communication skills in English is a requirement. In considering applications for the position, the main emphasis will be on the applicant's ability to document a high level of original scientific work at an international level within the area of computational chemistry and molecular design - directly related to drug discovery applications. Relevant areas of experience may include:  
 

  • Development and direct application of computational methods to structure-based-ligand-design and drug discovery, including: molecular modelling of protein ligand complexes, molecular dynamics simulations, development of methods for advanced structure and ligand based design, enumeration of chemical libraries, large scale structure based virtual screening and analysis. 
  • Experience with medicinal chemistry and compound optimization. 
  • Extensive experience with Linux and programming languages such as C, Python or Perl. 
Specific knowledge in these areas is less critical than outstanding intellectual ability, unusually strong computational research skills, and a history of innovation and accomplishment together with a high level of motivation and strong collaborative skills.  
 
We are committed to fostering a stimulating, rewarding, and flexible work environment for candidates of truly exceptional ability. 
 
Application:
The deadline for applications is, 1st of March 2018. We only accept online applications. For any administrative queries, please contact HR Consultant Henriette Strand Nielsen, e-mail hsn@sund.ku.dk  
 
The application should include: 
  • Current curriculum vitae 
  • Copies of relevant diplomas  
  • Complete publication list 
  • Motivated application 
 
Employment Conditions: 
Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organizations. The position is covered by the Job Structure for Academic Staff at Universities 2013.   
The position will be at the level of postdoctoral fellow. The gross basic salary range for Postdoctoral Fellows is DKK 33,224 to DKK 34,980 per month (level 6 to 8). To the basic salary a supplement could be negotiated, dependent on the candidate’s experience and qualifications. An additional 17.1 % monthly contribution to pension will be paid by the employer.   
 
Starting date is 1st April 2018 or as soon as possible hereafter.   
 
For information on current projects and the position, interested candidates are encouraged to contact Thomas M. Frimuer (thomas.frimurer@sund.ku.dk)
 
 


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