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Postdoctoral position to study the DNA damage response in reproductive aging using mouse models at the Center for Chromosome Stability, University of Copenhagen, Denmark

The Danish National Research Foundation (DNRF) Center for Chromosome Stability at Faculty of Health & Medical Sciences at the University of Copenhagen is looking for a postdoctoral scientist to join the Center, starting in March 2018, or upon agreement.   
 
The DNRF Center for Chromosome Stability is a part of Department of Cellular and Molecular Medicine at University of Copenhagen (http://www.icmm.ku.dk) addresses basic research questions in chromosome biology and translates promising basic research results into new strategies and targets for the development of new therapies for cancer and reproductive health. Find more information about the Center at http://ccs.ku.dk ;
 
The position is available in the laboratory of Prof. ER Hoffmann lab and is financed by an ERC Consolidator Award. The CCS opened in 2015 and is financed for six years by the DNRF. The position is available in the first instance for 3 years, with a possible extension for two further years.  
 
Job description 
Hoffmann lab is recruiting a talented and motivated postdoctoral scientist with a background in mouse genetics. The scientist will be involved in the maintenance and implementation of assessing ovarian function and other aging phenotypes in mouse models of DNA repair and DNA damage response (DDR) genes. The DDR was recently implicated in determining reproductive lifespan in human and the successful candidate will be involved in model selection based on genome-wide association studies (GWAS) and RNA expression profiles from oocytes and preimplantation embryos. The project will involve human cell line work to phenotype common variants in human DDR genes in response to DNA damaging agents. Initially, the project will focus on the role of ATR-CHK1 and ATM-CHK2-BRCA1 but other models are also available locally in the Center for Healthy Aging and the CCS. 
 
Your profile 
A relevant PhD in mouse genetics is required in addition to: 
 

  • Experience with the DDR or single cell genomics (RNA seq. or DNA seq.) 
  • The ability to work as part of a team is essential 
  • Interest in developing mouse models to reflect human genetic disorders 
  • Computer profiency and excellent English 
  • FELASA A/B/D (formerly C) is required 
  • CRISPR-Cas9 experience is advantageous 
  • Mouse embryology, microinjection into oocytes or embryos is an advantage 
  • Human cell line work is also an advantage 
  • A track record of publication-standard research is an advantage 
  • Integrity, enthusiasm, motivation, flexibility, confidence and good collaboration skills. 
  • High degree of organization 
We offer 

  • Stimulating, challenging and multifaceted research environment 
  • possibility for continued education and training   
  • attractive employment conditions   
  • centrally located in Copenhagen and family friendly work place   
The Hoffmann lab consists of 10 members and work on genomic variability in the germline of humans and its intersection with reproductive health (Capalbo et al, Hum. Reprod. Update 2017). Specifically, we focus on genome stability and the DNA damage response in the mammalian germline (Ottolini et al. 2015, Nat Genet 47: 727-35). The successful candidate will lead the mouse project and collaborate with other members of the lab, who use human tissues and who use single-cell genomics, RNA-seq and DNA-seq of human and mouse oocytes as well as embryos. In addition to the scientific requirements, the project requires excellent interpersonal skills to work as part of a team. English is the working language. There is no requirement for Danish. 
 
Scientific environment 
The mission of the Center for Chromosome Stability is to better understand the molecular mechanisms by which chromosomal instability impacts on age-related pathologies in humans. The research environment at the CCS is ambitious and international, with many different nationalities represented. The CCS comprises modern laboratories and seminars with high-profile international speakers and regular internal research seminars.


The CCS is part a greater research environment at The Department of Cellular and Molecular Medicine (ICMM) aiming to produce research with high international impact. The research focus is on the functional cell, its genetic components and molecular cellular mechanisms in a medical context. The ICMM currently comprises five research programmes, three high profile research centers, as well as a number of international research groups. The scientists at ICMM are also involved in high quality research based undergraduate and graduate teaching programs at the University of Copenhagen. You can read more about the CCS here: http://www.ccs.ku.dk ;
 
Required qualifications  
The project requires a PhD in mouse genetics and a FELASA A/B/D certificate. Training will be provided in various aspects required in this project, however, candidates with experience in mouse embryology (including biopsies), in vitro maturation of mammalian oocytes, and a good understanding of genetics are preferred. 
 
Terms of employment  
The terms of employment are set according to the Agreement between the Ministry of Finance and The Danish Confederation of Professional Associations or other relevant professional organization. Successful applicants will receive a generous salary from the University of Copenhagen as well as a monthly contribution of 17.1% of the salary paid into a pension fund.  
The University of Copenhagen encourages career development of its postdoctoral fellows and the position carries the opportunity to conduct undergraduate teaching and associated examinations within the Medical School. 
 
Questions 
For further information about the position, please contact Professor Eva Hoffmann by email: eva@sund.ku.dk 
Foreign applicants may find the following links useful: http://ism.ku.dk/(International Staff Mobility) and http://www.workingconditions.ku.dk
 
Application procedure 
The application must be submitted in English, by clicking on “Apply online” below, and must include the following: 
*Curriculum vitae with a list of publications, a report on previous research undertaken, and the names, addresses and contact details of 3 referees 
*Diplomas – all relevant certificates, including grades 
*An outline of how you could contribute scientifically and intellectually to the research of this laboratory (approximately 1 A4 page 
 
Please note the applicant will be contacted if the assessment committee requires further documentation.  
 
Deadline for application is 28th of February, 2018. 
 
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at http://employment.ku.dk ;
 
Apply online 
Founded in 1479, the University of Copenhagen is the oldest university in Denmark. With 37,000 students and 9,000 employees, it is among the largest universities in Scandinavia and one of the highest ranking in Europe. The University consists of six faculties, which cover Health and Medical Sciences, Humanities, Law, Science, Social Sciences and Theology. 
 


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