Postdoctoral positions in computational biology and clinical proteomics

Novo Nordisk Foundation Center for Protein Research
 
 
One or more postdoctoral positions are available in the clinical proteomics group at Novo Nordisk Foundation Center for Protein Research (CPR – www.cpr.ku.dk). The Center has been established at the Faculty of Health and Medical Sciences, University of Copenhagen, to promote research on human proteins of medical relevance. The Center comprises a wide range of expertise and resources including proteomics, structural biology, cell biology, advanced imaging technologies protein production and characterization of disease mechanisms. The clinical proteomics group is led by Prof. Dr. Matthias Mann, a leading authority in mass spectrometry-based proteomics.  
 
The clinical proteomics group develops and applies proteomics technology with a goal of understanding health and disease and making an impact in public health. We work in close synergy with the Proteomics and Cell Signaling group at the Max-Planck Institute of Biochemistry in Munich, which is also led by Prof. Mann as well as other groups at the CPR, especially Prof. Chunaram Choudhary in cell signaling and Prof. Søren Brunak in bioinformatics and patient record mining.
 
Our particular focus is on the plasma proteome in the context of metabolic disorders such as diabetes. To this end, we are developing technology for the rapid and large scale analysis of plasma proteomes using mass spectrometry-based proteomics to a depth of at least 1000 proteins per patient. We have termed this approach ‘plasma proteome profiling’ and our goal is to develop it into a comprehensive tool for medical diagnostics (Geyer et al, Cell Systems 2016). We are currently looking for talented and motivated post-doctoral fellows with experience in computational biology to join a young and dynamic team in beautiful Copenhagen.  
 
For more information about the research group please visit:  
http://www.cpr.ku.dk/research/proteomics/mann-group/    
 
Project Description  
The clinical proteomics group was established with a generous grant from Novo Nordisk Foundation in December 2015. At this point, we have developed part of the technology required for deep plasma proteomics and we have started to apply this technology to small and medium scale clinical studies. Characterizing the plasma proteome in metabolic diseases such as diabetes and life style (diet and exercise) are current priorities. Longer term we have many other interests such as applying the technology in the context of cancer patient stratification, assessing the efficacy of intervention, developing biomarkers in neurodegenerative diseases, to name just a few.  
The successful candidate should be able to contribute to the development and application of new computational tools that use large scale proteomics (or other omics datasets) to increase our knowledge of biology and to advance the diagnosis, treatment or prevention of diseases. He or she should be able to develop new and innovative (multi) omics modeling and visualization methods to make the results accessible and comprehensible to research scientists and clinicians. The candidate is also expected to work in close collaborations with Prof. Søren Brunak’s group at CPR.  
Estimated start date: March/April 2018  
 
Qualifications  

  • PhD in mathematics, computer science, bioinformatics or related field and proven track record in data science, machine-learning, computational life science, computer science, computational biology/chemistry, mathematics or statistics
  • Demonstrated experience in programming and scripting languages such as Python, R or Java  
  • Enthusiasm for visual analytics and data science  
  • Excellent scientific track record, including at least one publication as first author in a high-quality, peer reviewed international journal
  • Experience with analysis of proteomics or other omics data would be considered a distinct advantage  
  • Ideally skills would include knowledge of databases (i.e. graph databases) and experience with high-performance computing environments  
  • The candidate needs to be able to work effectively in an international and multidisciplinary team  
  • Strong written and verbal communication skills in English  
  • Ability to work independently and collaboratively on multiple projects in parallel  
Place of employment and work  
The employment is at CPR (www.cpr.ku.dk), University of Copenhagen, located in central Copenhagen. The research environment at CPR is vibrant and ambitious but also supportive. Currently about 30 different nationalities are represented. The Center comprises modern laboratories and state-of-the-art facilities in protein science and related areas. The institute regularly organizes seminars with high-profile international speakers as well as other events.  
 
Terms of salary and employment  
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary is around 33,200 – 34,900 DKK (around 4,550€) plus 17.1 % in pension contribution. The position will be 2-3 years.  
 
Application  
Please submit your application electronically to:  
http://employment.ku.dk/faculty/    
 
Your application should include the following documents:  
  • Letter of motivation for the application 
  • Curriculum vitae, incl. education and experience  
  • List of publications  
  • Letters of recommendation  
  • Names and contact details for at least two referees  
 
For further information about the position, please contact CPR:  
Jobs@cpr.ku.dk    
 
Deadline for application: 1 March 2018  
 
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at http://employment.ku.dk    
 
 


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