Senior Research Associate/Scientist, Protein Expression and purification

Senior Research Associate/Scientist, Protein Expression and purification

We are looking for a highly motivated and talented biochemist to join our Biologics team in Copenhagen, (DK). The successful candidate will be responsible for performing cloning, expression, protein purification and characterization of a wide variety of bispecific and trispecific antibody formats. He/She will be a key player in providing protein reagents to support platform innovation group. The successful candidate will work with Dragonfly’s talented team to discover and develop therapies that stimulate immune responses against solid and hematologic cancers. Dragonfly TX is an exciting young company that offers a fantastic culture and great opportunities to enhance your skills and grow your career!


Responsibilities

  • Participate in sequence analysis, cloning, vector construction and other molecular biology activities
  • Production of proteins at different scale in Expoi293 and ExpiCHO cells
  • Perform purification of mono- and multispecific mAbs
  • Perform protein characterization by SDS-PAGE, SEC-HPLC, cIEF, western blot
  • Maintain laboratory instrumentation
  • Maintain electronic laboratory notebooks and records to support technology transfer to internal or external groups as well as to support regulatory filings

Qualifications

  • B.Sc./M.Sc. with 5+ years’ experience or PhD. with 1+years of experience in protein expression, purification and analysis in a fast-paced industrial setting
  • Hands-on experience with standard molecular biology skills including bacterial culture and transformation, PCR, molecular cloning (including Gibson cloning), DNA purification, restriction digestion, sequence analysis and vector construction.
  • Extensive hands-on experience in mono- and bispecific antibody, scFV, antibody-fusion generation using transient ExpiCHO, Expi293. Experience with other protein production systems and stable CHO pools and lines generation is a plus.
  • Demonstrated experience with purification of proteins using affinity, IEX, HIC and other chromatography methods
  • Hands-on experience with AKTA Chromatography systems including ability to develop custom methods and troubleshoot
  • Experience with protein characterization techniques such as SDS-PAGE, western blot, analytical SEC.
  • Excellent organizational skills, with the ability to multi-task in a fast-paced environment with changing priorities
  • Excellent record keeping abilities, to document analytical data generated in support of regulatory requirements, adherence to GDP, experience with ELN.

About Dragonfly

Founded in 2015 by Dr. Tyler Jacks, head of the Koch Institute at MIT, Dr. David Raulet, one of the world's leading experts in Natural Killer (NK) cell biology, and Bill Haney, a longtime tech entrepreneur and investor, Dragonfly Therapeutics was launched to harness the power of the immune system to provide breakthrough treatments for patients – especially in areas where there are no effective treatments, today.


The company develops novel first-in-class therapeutics designed to harness Natural Killer cells and other cells of the innate immune system which can provide direct killing of disease promoting cell types, and provide a unique therapeutic window beyond current therapies for treatment of cancer and chronic inflammatory diseases. Please visit our websitefor details.


We offer

Our employees are fundamental to our success, and we continue to be able to attract and retain people with different experiences and backgrounds. We have a high-performing, collaborative culture characterized by respectful and diverse teams who are committed to our patients first mission.


At Dragonfly, you will have the opportunity to have impact, work with some of the brightest minds in the industry, develop your professional career, and contribute to breakthrough medicines for patients with urgent unmet medical needs.


Your application

Please apply by sending a cover letter and resume as soon as possible through the button "Apply / Send ansøgning". We are screening and interviewing for the position on an ongoing basis. For any further questions please email hr@dragonflytx.com


For more info, check out our career site https://dragonflytx.ofir.com


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