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Two-year post doc position in prostate cancer genomics and translational research at Department of Molecular Medicine (MOMA), Aarhus University, Denmark

The position
We seek a motivated and independent candidate for a two-year post doc position in prostate cancer genomics and translational research, available at Dept. of Clinical Medicine, Faculty of Health, Aarhus University and physically located at Dept. of Molecular Medicine (MOMA), Aarhus University Hospital.

The position is available from 1st December 2019, or as soon as possible thereafter.

The work environment
MOMA (https://moma.dk/) offers a vibrant interdisciplinary research environment with more than 20 years’ experience in translational cancer research and genomics, including transcriptomics and epigenomics. The multi-disciplinary academic staff at MOMA includes e.g. molecular biologists, clinicians, and bioinformaticians. MOMA houses state-of-the-art laboratory facilities, large cancer biobanks and a next-generation sequencing (NGS) facility with access to a powerful HPC facility. Moreover, MOMA houses the newly established Danish National Genome Center Whole-Genome Sequencing (WGS) facility.

The prostate cancer (PC) group at MOMA, lead by Prof. Karina Dalsgaard Sørensen, is a dynamic research group that includes several postdocs, PhD students, MSc/BSc, and MD students. We are result-orientated, while supporting a good collaborative working environment. Our research aims to generate new molecular and biological insight into PC, mainly by sequencing (NGS) of PC patient cohorts. This approach is often combined with functional studies of candidate genes in preclinical models, using e.g. CRISPR tools for genomic editing. Project activities are generally multi-disciplinary, ranging from basic molecular biology to clinical trials, and with a clear translational focus. We work closely together with other clinical departments at AUH and are engaged in several local, national and international research collaborations, e.g. the leading global PC consortia PRACTICAL (http://practical.icr.ac.uk/blog/) and PPCG (https://panprostate.org/).

The project
The project concerns molecular prediction of prostate cancer (PC) aggressiveness through analyses of genome, transcriptome and/or epigenome sequencing data (e.g. WGS, RNA-Seq, MeDIP-Seq) generated from PC patient samples. Hence, the work will mainly involve bioinformatics analyses of tumor sequencing data (generated in house, and combined with public/consortium data) and to a lesser extent experimental laboratory work, although this balance may be slightly adjusted depending on the candidate.

The project will also involve establishment of methods for NGS-based epigenomic (methylation) profiling of circulating tumor DNA (ctDNA) in plasma/blood samples from PC patients and/or single-cell RNA sequencing of PC tumors. As our research focus is translational, all results from the molecular and bioinformatics analyses will be compared with relevant patient data, e.g. tumor stage/grade and survival. The position may also include co-supervision of PhD, MSc, MD and/or BSc students.

Key criteria for the assessment of candidates
The candidates should have:

  • A PhD degree in molecular biology, molecular medicine, bioinformatics or similar.
  • Fluency in written and spoken English

Qualification requirements
The following professional and personal qualifications will be advantageous:
  • Published peer-reviewed articles in international journals
  • Research experience in cancer genomics, transcriptomics, and/or epigenomics
  • Knowledge about prostate cancer and/or cancer biology
  • Proficiency in the R or Python programming languages
  • Proficiency in medical statistical data analysis (using STATA, R or similar)
  • Experience with single cell sequencing or liquid biopsy analyses
  • Rich in initiative and a strong motivation for research
  • Good collaborative skills
  • Good communication skills
  • Excellent English speaking, reading, and writing skills.

We offer
  • A stimulating, national and internationally well-connected research environment
  • Challenging projects in translational prostate cancer research / personalized medicine
  • Opportunities to develop your scientific skills, disseminate and publish your research

Please be aware that shortlisting will be used. Furthermore, due to a requirement from the external funding agency, the successful candidate must have obtained the PhD degree no earlier than the 2nd of October 2014 (can be extended in case of periods of parental/sick leave, military service, etc.).

Terms of employment
Application
Your application must include the following:
  • Motivated application
  • Curriculum Vitae
  • Diploma
  • A list of publications
  • A teaching portfolio. We refer to Guideline on the use of teaching portfolios
  • A maximum of five of the publications of greatest relevance to the job may be submitted
  • References/recommendations can be uploaded separately in the e-recruitment system
  • Template for applicant - postdoc must be completed and uploaded under ‘Extra documents’

We refer to the faculty’s Guidelines for applicants.

The assessment committee may decide to include non-submitted material in its statement. In such cases, you will be informed and obliged to submit material, unless your application is withdrawn.

All interested candidates are encouraged to apply, regardless of their personal background.

International applicant?
Aarhus University offers a broad variety of services for international researchers and accompanying families, including relocation service and career counselling to expat partners. Please find more information about entering and working in Denmark here. Aarhus University also has a Junior Researcher Development Programme. You can read more about it here.

The application must be submitted via Aarhus University’s recruitment system, which can be accessed under the job advertisement on Aarhus University's website.

Aarhus University
Aarhus University is an academically diverse and research-intensive university with a strong commitment to high-quality research and education and the development of society nationally and globally. The university offers an inspiring research and teaching environment to its 38,000 students (FTEs) and 8,000 employees, and has an annual revenues of EUR 885 million. Learn more at www.international.au.dk/

Deadline:
16 October 2019

 


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